Advancing the application of omics-based biomarkers in environmental epidemiology

Authors

  • Paolo Vineis,

    Corresponding author
    1. MRC-HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
    2. Molecular and genetic epidemiology Unit, HuGeF, Human Genetics Foundation, Torino, Italy
    • Correspondence to: Paolo Vineis, MRC-HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom. E-mail: p.vineis@imperial.ac.uk

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  • Karin van Veldhoven,

    1. MRC-HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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  • Marc Chadeau-Hyam,

    1. MRC-HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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  • Toby J. Athersuch

    1. MRC-HPA Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
    2. Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, South Kensington, London, United Kingdom
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Abstract

The use of omics represents a shift in approach for environmental epidemiology and exposure science. In this article, the aspects of the use of omics that will require further development in the near future are discussed, including (a) the underlying causal interpretation and models; (b) the “meet-in-the-middle” concept, with examples; (c) the role of “calibration” of measurements; and (d) the role of life-course epidemiology and the related development of adequate biostatistical models. Environ. Mol. Mutagen. 54:461-467, 2013. © 2013 Wiley Periodicals, Inc.

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