Environmental and Molecular Mutagenesis

Cover image for Environmental and Molecular Mutagenesis

April - May 2007

Volume 48, Issue 3-4

Pages 159–343

  1. Foreword

    1. Top of page
    2. Foreword
    3. Review Articles
    4. Perspectives
    5. Research Articles
    6. Commentary
    7. Review Articles
    8. Research Articles
  2. Review Articles

    1. Top of page
    2. Foreword
    3. Review Articles
    4. Perspectives
    5. Research Articles
    6. Commentary
    7. Review Articles
    8. Research Articles
    1. A brief overview of mechanisms of mitochondrial toxicity from NRTIs (pages 166–172)

      James J. Kohler and William Lewis

      Article first published online: 6 JUN 2006 | DOI: 10.1002/em.20223

  3. Perspectives

    1. Top of page
    2. Foreword
    3. Review Articles
    4. Perspectives
    5. Research Articles
    6. Commentary
    7. Review Articles
    8. Research Articles
    1. Clinical mitochondrial dysfunction in uninfected children born to HIV-infected mothers following perinatal exposure to nucleoside analogues (pages 173–178)

      Valérie Benhammou, Marc Tardieu, Josiane Warszawski, Pierre Rustin and Stéphane Blanche

      Article first published online: 14 MAR 2007 | DOI: 10.1002/em.20279

  4. Research Articles

    1. Top of page
    2. Foreword
    3. Review Articles
    4. Perspectives
    5. Research Articles
    6. Commentary
    7. Review Articles
    8. Research Articles
    1. Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to Zidovudine (pages 179–189)

      Rao L. Divi, Kathryn J. Haverkos, Juliette A. Humsi, Marie E. Shockley, Chandrasekhar Thamire, Kunio Nagashima, Ofelia A. Olivero and Miriam C. Poirier

      Article first published online: 7 AUG 2006 | DOI: 10.1002/em.20245

    2. Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination (pages 190–200)

      Sherine S.L. Chan, Janine H. Santos, Joel N. Meyer, Bhaskar S. Mandavilli, Dennis L. Cook Jr., Consuelo L. McCash, Grace E. Kissling, Abraham Nyska, Julie F. Foley, Bennett van Houten, William C. Copeland, Vernon E. Walker, Kristine L. Witt and Jack B. Bishop

      Article first published online: 4 JAN 2006 | DOI: 10.1002/em.20191

    3. Transplacentally exposed human and monkey newborn infants show similar evidence of nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity (pages 201–209)

      Rao L. Divi, Sarah L. Leonard, Maryanne M. Kuo, Kunio Nagashima, Chandrasekhar Thamire, Marisa C. St. Claire, Nancy A. Wade, Vernon E. Walker and Miriam C. Poirier

      Article first published online: 14 MAR 2006 | DOI: 10.1002/em.20201

  5. Commentary

    1. Top of page
    2. Foreword
    3. Review Articles
    4. Perspectives
    5. Research Articles
    6. Commentary
    7. Review Articles
    8. Research Articles
  6. Review Articles

    1. Top of page
    2. Foreword
    3. Review Articles
    4. Perspectives
    5. Research Articles
    6. Commentary
    7. Review Articles
    8. Research Articles
  7. Research Articles

    1. Top of page
    2. Foreword
    3. Review Articles
    4. Perspectives
    5. Research Articles
    6. Commentary
    7. Review Articles
    8. Research Articles
    1. Mutagenicity of zidovudine, lamivudine, and abacavir following in vitro exposure of human lymphoblastoid cells or in utero exposure of CD-1 mice to single agents or drug combinations (pages 224–238)

      Salina M. Torres, Dale M. Walker, Meghan M. Carter, Dennis L. Cook Jr., Consuelo L. McCash, Edmund M. Cordova, Ofelia A. Olivero, Miriam C. Poirier and Vernon E. Walker

      Article first published online: 14 MAR 2007 | DOI: 10.1002/em.20264

    2. Relative mutagenic potencies of several nucleoside analogs, alone or in drug pairs, at the HPRT and TK loci of human TK6 lymphoblastoid cells (pages 239–247)

      Meghan M. Carter, Salina M. Torres, Dennis L. Cook Jr., Consuelo L. McCash, Mia Yu, Vernon E. Walker and Dale M. Walker

      Article first published online: 14 MAR 2007 | DOI: 10.1002/em.20282

    3. 3′-azido-3′-deoxythymidine induces deletions in L5178Y mouse lymphoma cells (pages 248–257)

      Jianyong Wang, Tao Chen, Masamitsu Honma, Ling Chen and Martha M. Moore

      Article first published online: 14 MAR 2007 | DOI: 10.1002/em.20263

    4. Transplacental drug transfer and frequency of Tk and Hprt lymphocyte mutants and peripheral blood micronuclei in mice treated transplacentally with zidovudine and lamivudine (pages 258–269)

      Linda S. Von Tungeln, Lee D. Williams, Daniel R. Doerge, Joseph G. Shaddock, Lynda J. McGarrity, Suzanne M. Morris, Roberta A. Mittelstaedt, Robert H. Heflich and Frederick A. Beland

      Article first published online: 18 JUL 2006 | DOI: 10.1002/em.20237

    5. Frequency of Hprt mutant lymphocytes and micronucleated erythrocytes in p53-haplodeficient mice treated perinatally with AZT and AZT in combination with 3TC (pages 270–282)

      Vasily N. Dobrovolsky, Joseph G. Shaddock, Roberta A. Mittelstaedt, Michelle E. Bishop, Sherry M. Lewis, Fei W. Lee, Anane Aidoo, Julian E.A. Leakey, June K. Dunnick and Robert H. Heflich

      Article first published online: 14 MAR 2007 | DOI: 10.1002/em.20280

    6. Transplacental carcinogenicity of 3′-azido-3′-deoxythymidine in B6C3F1 mice and F344 rats (pages 283–298)

      Dale M. Walker, David E. Malarkey, Steven K. Seilkop, Frederick A. Ruecker, Kathleen A. Funk, Marilyn J. Wolfe, Christopher P. Treanor, Julie F. Foley, Fletcher F. Hahn, Jerry F. Hardisty and Vernon E. Walker

      Article first published online: 14 MAR 2007 | DOI: 10.1002/em.20297

    7. Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from Swiss (CD-1) male mice exposed transplacentally to AZT (pages 299–306)

      Hue-Hua L. Hong, June Dunnick, Ronald Herbert, Theodora R. Devereux, Yongbaek Kim and Robert C. Sills

      Article first published online: 4 JAN 2006 | DOI: 10.1002/em.20197

    8. Plasma and cellular markers of 3′-azido-3′-dideoxythymidine (AZT) metabolism as indicators of DNA damage in cord blood mononuclear cells from infants receiving prepartum NRTIs (pages 307–321)

      Quanxin Meng, Ofelia A. Olivero, Michael J. Fasco, Ronald Bellisario, Laurence Kaminsky, Ken A. Pass, Nancy A. Wade, Elaine J. Abrams, Carol J. Nesel, Roberta B. Ness, William L. Bigbee, J. Patrick O'Neill, Dale M. Walker, Miriam C. Poirier and Vernon E. Walker

      Article first published online: 14 MAR 2007 | DOI: 10.1002/em.20298

    9. Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIV (pages 322–329)

      Kristine L. Witt, Coleen K. Cunningham, Kristine B. Patterson, Grace E. Kissling, Stephen D. Dertinger, Elizabeth Livingston and Jack B. Bishop

      Article first published online: 14 MAR 2007 | DOI: 10.1002/em.20266

    10. Genotoxicity assessed by the comet and GPA assays following in vitro exposure of human lymphoblastoid cells (H9) or perinatal exposure of mother–child pairs to AZT or AZT-3TC (pages 330–343)

      Patricia A. Escobar, Ofelia A. Olivero, Nancy A. Wade, Elaine J. Abrams, Carol J. Nesel, Roberta B. Ness, Richard D. Day, Billy W. Day, Quanxin Meng, J. Patrick O'Neill, Dale M. Walker, Miriam C. Poirier, Vernon E. Walker and William L. Bigbee

      Article first published online: 14 MAR 2007 | DOI: 10.1002/em.20285

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