See also: B Liu et al (December 2013)
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PIAS adds methyl-bias to HSC-differentiation
Article first published online: 14 JAN 2014
© 2014 The Author
The EMBO Journal
Volume 33, Issue 2, pages 93–95, 16 January 2014
How to Cite
Ghaffari, S. (2014), PIAS adds methyl-bias to HSC-differentiation. The EMBO Journal, 33: 93–95. doi: 10.1002/embj.201387332
- Issue published online: 14 JAN 2014
- Article first published online: 14 JAN 2014
Epigenetic modifications of stem cell genome including DNA methylation and histone modifications are critical for the regulation of stem cell gene expression and maintenance of stem cell pool and their differentiation. Although the importance of epigenetic modifications specifically DNA methylation to adult hematopoietic stem cells (HSC) has been established, the identity of specific modulators and precise mechanism of integration of methylation events remain to be uncovered. In this issue, Shuai and colleagues identify the SUMO E3 ligase PIAS1 (protein inhibitor of activated STAT1) as a key regulator of DNA methylation of HSC required for their maintenance and lineage commitment (Liu et al, 2014).