See related article http://dx.doi.org/10.1016/j.cell.2013.09.059
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Lin28a – boost your energy for youthful regeneration
Article first published online: 20 DEC 2013
© 2014 The Authors
The EMBO Journal
Volume 33, Issue 1, pages 5–6, 2 January 2014
How to Cite
Burkhalter, M. D., Morita, Y. and Rudolph, K. L. (2014), Lin28a – boost your energy for youthful regeneration. The EMBO Journal, 33: 5–6. doi: 10.1002/embj.201387363
- Issue published online: 7 JAN 2014
- Article first published online: 20 DEC 2013
The regenerative capacity of most tissues declines dramatically after embryonic development and during post-natal life. The underlying mechanisms of this phenomenon are incompletely understood. In a recent issue of Cell, Shyh-Chang and colleagues provide experimental evidence that Lin28 prolongs youthful regenerative capacity by increasing oxidative glucose metabolism (Shyh-Chang et al, 2013).