See also: D Muñoz-Espín et al (Cell, November 2013)
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The benefits of aging: cellular senescence in normal development
Article first published online: 22 DEC 2013
© 2013 The Authors
The EMBO Journal
Volume 33, Issue 2, pages 99–100, 16 January 2014
How to Cite
Pérez-Garijo, A. and Steller, H. (2014), The benefits of aging: cellular senescence in normal development. The EMBO Journal, 33: 99–100. doi: 10.1002/embj.201387401
and M Storer et al (Cell, November 2013)
- Issue published online: 14 JAN 2014
- Article first published online: 22 DEC 2013
- Manuscript Accepted: 15 NOV 2013
- Manuscript Received: 13 NOV 2013
Senescence is a form of cellular aging that limits the proliferative capacity of cells. Senescence can be triggered by different stress stimuli, such as DNA damage or oncogene activation. Two recent articles published in Cell have uncovered an unexpected role for cellular senescence during development, as a process that contributes to remodeling and patterning of the embryo. These findings are exciting and have important implications for the understanding of normal developmental and the evolutionary origin of senescence.