See also: T Ahmad et al (May 2014)
Have you seen?
Miro1: New wheels for transferring mitochondria
Version of Record online: 7 APR 2014
© 2014 The Authors
The EMBO Journal
Volume 33, Issue 9, pages 939–941, 2 May 2014
How to Cite
Las, G. and Shirihai, O. S. (2014), Miro1: New wheels for transferring mitochondria. The EMBO Journal, 33: 939–941. doi: 10.1002/embj.201488441
- Issue online: 2 MAY 2014
- Version of Record online: 7 APR 2014
- National Institutes of Health. Grant Numbers: RO1 DK074778, RO1 DK56690-11
- Israel Science foundation. Grant Number: ISF 87341911
Mesenchymal stem cells (MSC) are capable of protecting cells harboring mitochondrial damage. This protection is associated with the transfer of mitochondria through tunneling nanotubes (TNT) from MSC to the injured cells. In this issue of The EMBO Journal, the group of Anurag Agrawal shows that mitochondrial transfer is dependent on the levels of Miro1, a mitochondrial Rho-GTPase that regulates intercellular mitochondrial movement. Miro1 is the first protein shown to accelerate mitochondrial transfer. Amplifying the mitochondrial transfer phenomenon may allow for the study of the mechanisms that regulate it and contribute to our understanding of its role in disease and aging.