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The EMBO Journal

Cover image for Vol. 33 Issue 1

2 January 2014

Volume 33, Issue 1

Pages 1–92

  1. Editorial

    1. Top of page
    2. Editorial
    3. Have you seen?
    4. Review
    5. Articles
    1. You have free access to this content
      EMBO Press – a new way to publish (pages 1–2)

      Bernd Pulverer

      Version of Record online: 7 JAN 2014 | DOI: 10.1002/embj.201387566

  2. Have you seen?

    1. Top of page
    2. Editorial
    3. Have you seen?
    4. Review
    5. Articles
    1. You have free access to this content
      Control not at initiation? Bah, humbug! (pages 3–4)

      William C. Merrick and Michael E. Harris

      Version of Record online: 22 DEC 2013 | DOI: 10.1002/embj.201387388

      Thumbnail image of graphical abstract

      The presence of rare codons in an mRNA can reduce translation elongation speed and make ribosome clearance of the start codon rate-limiting for protein synthesis.

    2. You have free access to this content
      Lin28a – boost your energy for youthful regeneration (pages 5–6)

      Martin D. Burkhalter, Yohei Morita and Karl Lenhard Rudolph

      Version of Record online: 20 DEC 2013 | DOI: 10.1002/embj.201387363

      Thumbnail image of graphical abstract

      Establishing Lin28 as metabolic regulator offers a fresh perspective on crucial mechanisms of age-dependent regenerative capacity.

  3. Review

    1. Top of page
    2. Editorial
    3. Have you seen?
    4. Review
    5. Articles
    1. You have free access to this content
      The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus (pages 7–22)

      Michal Schwartz and Kuti Baruch

      Version of Record online: 20 DEC 2013 | DOI: 10.1002/embj.201386609

      Thumbnail image of graphical abstract

      Michal Schwartz and Kuti Baruch review the immunological processes involved in neuroinflammation and neurodegeneration, and how inflammation-resolving cells are recruited to the CNS.

  4. Articles

    1. Top of page
    2. Editorial
    3. Have you seen?
    4. Review
    5. Articles
    1. You have free access to this content
      Translation elongation can control translation initiation on eukaryotic mRNAs (pages 21–34)

      Dominique Chu, Eleanna Kazana, Noémie Bellanger, Tarun Singh, Mick F Tuite and Tobias von der Haar

      Version of Record online: 20 DEC 2013 | DOI: 10.1002/embj.201385651

      Thumbnail image of graphical abstract

      Codon usage-dependent ribosomal elongation speed can control translational output by securing fast ribosome clearance of the start codon. Highly expressed proteins preferentially harbour ‘fast codons’ downstream of the initiation site.

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      Cell adhesion defines the topology of endocytosis and signaling (pages 35–45)

      Jean-Philippe Grossier, Georgia Xouri, Bruno Goud and Kristine Schauer

      Version of Record online: 7 JAN 2014 | DOI: 10.1002/embj.201385284

      Thumbnail image of graphical abstract

      Cells on micropatterned surfaces show asymmetric uptake of transferrin at adhesive areas that is dependent on the enrichment of clathrin and adaptor protein 2, and EGF at the dorsal side regulated by the actin cytoskeleton.

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      Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chains (pages 46–61)

      Weixiao Liu, Yongliang Shang, Yan Zeng, Chao Liu, Yanchang Li, Linhui Zhai, Pan Wang, Jizhong Lou, Ping Xu, Yihong Ye and Wei Li

      Version of Record online: 7 JAN 2014 | DOI: 10.1002/embj.201385315

      Thumbnail image of graphical abstract

      Asymmetric interactions within an E2 enzyme homodimer facilitates ubiquitin positioning for assembly and subsequent en-bloc transfer of linkage-specific polyubiquitin chains.

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      The Arabidopsis PEPR pathway couples local and systemic plant immunity (pages 62–75)

      Annegret Ross, Kohji Yamada, Kei Hiruma, Misuzu Yamashita-Yamada, Xunli Lu, Yoshitaka Takano, Kenichi Tsuda and Yusuke Saijo

      Version of Record online: 16 DEC 2013 | DOI: 10.1002/embj.201284303

      Thumbnail image of graphical abstract

      Local microbial recognition involving PEPR pattern recognition receptors leads to a systemic immune response via the Salicylate and Jasmonate hormone signaling pathways.

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      The mechanism of translation initiation on Type 1 picornavirus IRESs (pages 76–92)

      Trevor R Sweeney, Irina S Abaeva, Tatyana V Pestova and Christopher U T Hellen

      Version of Record online: 16 DEC 2013 | DOI: 10.1002/embj.201386124

      Thumbnail image of graphical abstract

      Viruses usurp a range of host genes to mediate efficient translation. The first in vitro reconstitution of initiation on picornavirus Type 1 IRESs reveals the set of translation factors minimally required for viral propagation.

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