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The EMBO Journal

Cover image for Vol. 33 Issue 11

02 June 2014

Volume 33, Issue 11

Pages 1193–1284

  1. Have you seen?

    1. Top of page
    2. Have you seen?
    3. Review
    4. Articles
    5. Corrigendum
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      The uncommon roles of common gene regulatory factors in the genomes of differentiating cells (pages 1193–1194)

      Eric H Davidson

      Article first published online: 30 APR 2014 | DOI: 10.1002/embj.201488693

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      The integration of various ‘systems-level’ analyses reveals functional, rather than opportunistic, promoter binding of a common set of hematopoietic transcription factors to govern tissue-specific gene expression.

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      The ER under rapid fire (pages 1195–1197)

      Benjamin M Schwenk and Dieter Edbauer

      Article first published online: 30 APR 2014 | DOI: 10.1002/embj.201488692

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      Combining the iPSC technology with genome-editing/genome-sequencing and cell-biological tools offers intriguing novel insights into the molecular aberrations that cause fatal motoneuron death in ALS patients.

  2. Review

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    3. Review
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      Playing TETris with DNA modifications (pages 1198–1211)

      Benjamin Delatte, Rachel Deplus and François Fuks

      Article first published online: 13 MAY 2014 | DOI: 10.15252/embj.201488290

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      While new functions of Ten Eleven Translocation (TET) enzymes are rapidly emerging, this review aims to summarize crucial aspects of their enzymatic activities, roles in reprogramming and disease with a particular emphasis on neuronal disorders.

  3. Articles

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      Key regulators control distinct transcriptional programmes in blood progenitor and mast cells (pages 1212–1226)

      Fernando J Calero-Nieto, Felicia S Ng, Nicola K Wilson, Rebecca Hannah, Victoria Moignard, Ana I Leal-Cervantes, Isabel Jimenez-Madrid, Evangelia Diamanti, Lorenz Wernisch and Berthold Göttgens

      Article first published online: 23 APR 2014 | DOI: 10.1002/embj.201386825

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      Comparative profiling of ten key haematopoietic transcription factors in blood progenitors versus mast cells demonstrates tissue-specific binding profiles that functionally determine cellular identify.

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      ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport (pages 1227–1242)

      Taro Chaya, Yoshihiro Omori, Ryusuke Kuwahara and Takahisa Furukawa

      Article first published online: 5 MAY 2014 | DOI: 10.1002/embj.201488175

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      Intestinal cell kinase (ICK) phosphorylates the kinesin-2 subunit Kif3a to regulate intraflagellar transport and therefore ciliary morphogenesis. ICK deficiency leads to cell type-specific loss of cilia and defective Sonic Hedgehog signaling during central nervous system development.

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      STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis (pages 1243–1255)

      Tomoyuki Fukuda, Nanaho Fukuda, Ana Agostinho, Abrahan Hernández-Hernández, Anna Kouznetsova and Christer Höög

      Article first published online: 5 MAY 2014 | DOI: 10.1002/embj.201387329

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      A hypomorphic allele of the meiosis-specific cohesin subunit STAG3/SA3 reveals its essential functions in meiotic chromosome organization and gametogenesis in mice.

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      Meiotic cohesin STAG3 is required for chromosome axis formation and sister chromatid cohesion (pages 1256–1270)

      Tristan Winters, Francois McNicoll and Rolf Jessberger

      Article first published online: 5 MAY 2014 | DOI: 10.1002/embj.201387330

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      Mice lacking STAG3/SA3, the least understood meiosis-specific cohesin subunit, are found to exhibit the strongest phenotype of any meiotic cohesin protein deficiency analyzed so far.

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      MiR-135b is a direct PAX6 target and specifies human neuroectoderm by inhibiting TGF-β/BMP signaling (pages 1271–1283)

      Akshay Bhinge, Jeremie Poschmann, Seema C Namboori, Xianfeng Tian, Sharon Jia Hui Loh, Anna Traczyk, Shyam Prabhakar and Lawrence W Stanton

      Article first published online: 6 MAY 2014 | DOI: 10.1002/embj.201387215

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      A genome-wide association study on the neural inducer Pax6 identifies miR-135b as a novel Pax6 target that promotes neuroectoderm induction by antagonizing BMP and Activin/Nodal signals.

  4. Corrigendum

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    3. Review
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      Origin plasticity during budding yeast DNA replication in vitro (page 1284)

      Julien Gros, Sujan Devbhandari and Dirk Remus

      Article first published online: 2 JUN 2014 | DOI: 10.15252/embj.201470070

      This article corrects:

      Origin plasticity during budding yeast DNA replication in vitro

      Vol. 33, Issue 6, 621–636, Article first published online: 24 FEB 2014

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