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The EMBO Journal

Cover image for Vol. 33 Issue 13

1 July 2014

Volume 33, Issue 13

Pages 1417–1502

  1. Have you seen?

    1. Top of page
    2. Have you seen?
    3. Review
    4. Articles
    5. Corrigendum
    1. You have free access to this content
      Sirtuin to the rescue: SIRT2 extends life span of BubR1 mice (pages 1417–1419)

      Claudia Cosentino and Raul Mostoslavsky

      Version of Record online: 11 JUN 2014 | DOI: 10.15252/embj.201488983

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      Similar to SIRT6 and SIRT1, the sirtuin SIRT2 regulates aging in mouse. Sirt2 deacetylates the mitotic checkpoint kinase BubR1, stabilizing it. Sirt2 overexpression increases the life span of hypomorphic BubR1H/H mice.

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      Wnt meets Warburg: another piece in the puzzle? (pages 1420–1422)

      Craig B Thompson

      Version of Record online: 19 MAY 2014 | DOI: 10.15252/embj.201488785

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      The discovery of PDK1 and the lactate transporter MCT-1 as direct Wnt targets functionally links Wnt signaling to the aerobic switch and critical angiogenic responses in tumor cells and normal stem cells.

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      Epithelial regeneration and cancer: news from the Src front (pages 1423–1424)

      Pedro Sousa-Victor and Heinrich Jasper

      Version of Record online: 22 MAY 2014 | DOI: 10.15252/embj.201488815

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      The experimental power of Drosophila and mouse models enables the functional dissection of distinct Src family kinase family members in the homeostasis of intestinal stem cells.

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      The Good, the Bad, and the Ugly of interleukin-6 signaling (pages 1425–1427)

      José J Fuster and Kenneth Walsh

      Version of Record online: 21 MAY 2014 | DOI: 10.15252/embj.201488856

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      Most recent work from the Brüning laboratory determines an unexpected, anti-inflammatory role of IL-6 in obesity-associated insulin resistance by virtue of alternative macrophage polarization.

  2. Review

    1. Top of page
    2. Have you seen?
    3. Review
    4. Articles
    5. Corrigendum
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      miRNAs at the interface of cellular stress and disease (pages 1428–1437)

      Anna Emde and Eran Hornstein

      Version of Record online: 27 MAY 2014 | DOI: 10.15252/embj.201488142

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      Anna Emde and Eran Hornstein discuss the interplay between the miRNA machinery and the cellular stress pathway and how this contributes to disease risk.

  3. Articles

    1. Top of page
    2. Have you seen?
    3. Review
    4. Articles
    5. Corrigendum
    1. You have free access to this content
      SIRT2 induces the checkpoint kinase BubR1 to increase lifespan (pages 1438–1453)

      Brian J North, Michael A Rosenberg, Karthik B Jeganathan, Angela V Hafner, Shaday Michan, Jing Dai, Darren J Baker, Yana Cen, Lindsay E Wu, Anthony A Sauve, Jan M van Deursen, Anthony Rosenzweig and David A Sinclair

      Version of Record online: 13 MAY 2014 | DOI: 10.15252/embj.201386907

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      The checkpoint kinase BubR1 declines in aging mice, and its overexpression increases lifespan. The NAD+-dependent deacetylase Sirt2 deacetylates BubR1, increasing its abundance and the lifespan of progeroid BubR1H/H mice.

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      Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer (pages 1454–1473)

      Kira T Pate, Chiara Stringari, Stephanie Sprowl-Tanio, Kehui Wang, Tara TeSlaa, Nate P Hoverter, Miriam M McQuade, Chad Garner, Michelle A Digman, Michael A Teitell, Robert A Edwards, Enrico Gratton and Marian L Waterman

      Version of Record online: 13 MAY 2014 | DOI: 10.15252/embj.201488598

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      Waterman and colleagues functionally characterize PDK1 as crucial contributor toward Wnt-dependent metabolic and angiogenic transformations during colon cancer progression.

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      c-Src drives intestinal regeneration and transformation (pages 1474–1491)

      Julia B Cordero, Rachel A Ridgway, Nicola Valeri, Colin Nixon, Margaret C Frame, William J Muller, Marcos Vidal and Owen J Sansom

      Version of Record online: 30 APR 2014 | DOI: 10.1002/embj.201387454

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      These comprehensive, cross-organismal experiments determine the evolutionary conservation and central position of Src family kinases in intestinal stem cell renewal, tumour formation and proliferative tissue regeneration.

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      Chromatin regulates DNA torsional energy via topoisomerase II-mediated relaxation of positive supercoils (pages 1492–1501)

      Xavier Fernández, Ofelia Díaz-Ingelmo, Belén Martínez-García and Joaquim Roca

      Version of Record online: 23 MAY 2014 | DOI: 10.15252/embj.201488091

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      Differential (+) and (−) torsional stress relaxation by topoisomerases I and II contributes to the overall negative supercoiling status of native chromatin, which may facilitate transactions such as DNA unwinding.

  4. Corrigendum

    1. Top of page
    2. Have you seen?
    3. Review
    4. Articles
    5. Corrigendum
    1. You have free access to this content
      Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis (page 1502)

      Allison N Lau, Stephen J Curtis, Christine M Fillmore, Samuel P Rowbotham, Morvarid Mohseni, Darcy E Wagner, Alexander M Beede, Daniel T Montoro, Kerstin W Sinkevicius, Zandra E Walton, Juliana Barrios, Daniel J Weiss, Fernando D Camargo, Kwok-Kin Wong and Carla F Kim

      Version of Record online: 1 JUL 2014 | DOI: 10.15252/embj.201488991

      This article corrects:

      Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis

      Vol. 33, Issue 5, 468–481, Version of Record online: 21 FEB 2014

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