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The EMBO Journal

Cover image for Vol. 33 Issue 2

16 January 2014

Volume 33, Issue 2

Pages 93–171

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    3. Articles
    4. Resource
    5. Corrigendum
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      PIAS adds methyl-bias to HSC-differentiation (pages 93–95)

      Saghi Ghaffari

      Version of Record online: 14 JAN 2014 | DOI: 10.1002/embj.201387332

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      The SUMO E3-ligase PIAS1 contributes to HSC-maintenance respective differentiation by regulating DNMT-recruitment to target gene promoters.

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      Short-circuiting microtubule plus and minus end proteins in spindle positioning (pages 96–98)

      Stephen L. Rogers

      Version of Record online: 14 JAN 2014 | DOI: 10.1002/embj.201387341

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      Interplay between γ-TuRC and EB1 controls mitotic spindle positioning by affecting stability and dynamics of astral microtubules.

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      The benefits of aging: cellular senescence in normal development (pages 99–100)

      Ainhoa Pérez-Garijo and Herman Steller

      Version of Record online: 22 DEC 2013 | DOI: 10.1002/embj.201387401

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      So far exclusively linked to pathological conditions, new studies place the onset of cellular senescence into the physiological context of organismal development.

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      PIAS1 SUMO ligase regulates the self-renewal and differentiation of hematopoietic stem cells (pages 101–113)

      Bin Liu, Kathleen M. Yee, Samuel Tahk, Ryan Mackie, Cary Hsu and Ke Shuai

      Version of Record online: 16 DEC 2013 | DOI: 10.1002/embj.201283326

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      Novel genetic results establish the ubiquitin E3-ligase PIAS1 as epigenetic regulator of HSC-dormancy and lineage restriction by direct repression of Gata1.

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      γ-Tubulin Ring Complexes and EB1 play antagonistic roles in microtubule dynamics and spindle positioning (pages 114–128)

      Anaїs Bouissou, Christel Vérollet, Hélène de Forges, Laurence Haren, Yohanns Bellaїche, Franck Perez, Andreas Merdes and Brigitte Raynaud-Messina

      Version of Record online: 14 JAN 2014 | DOI: 10.1002/embj.201385967

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      γ-TuRCs gain an unexpected mitotic function in stabilizing astral microtubules, independent of their essential microtubule nucleation roles at centrosomes.

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      EGFR controls IQGAP basolateral membrane localization and mitotic spindle orientation during epithelial morphogenesis (pages 129–145)

      Inmaculada Bañón-Rodríguez, Manuel Gálvez-Santisteban, Silvia Vergarajauregui, Minerva Bosch, Arantxa Borreguero-Pascual and Fernando Martín-Belmonte

      Version of Record online: 14 JAN 2014 | DOI: 10.1002/embj.201385946

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      Inactive EGFR recruits IQGAP1 to the basolateral membrane of epithelial cells to ensure proper NuMA-dependent mitotic spindle orientation. EGF-EGFR signaling disrupts IQGAP1 polarization, causing spindle misorientation and affecting lumen formation in epithelial tubules.

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      Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF (pages 146–156)

      Jurian Schuijers, Michal Mokry, Pantelis Hatzis, Edwin Cuppen and Hans Clevers

      Version of Record online: 10 JAN 2014 | DOI: 10.1002/embj.201385358

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      Integrated genome-wide ChIP-seq data in multiple cell types reveals that Tcf4 globally determines Wnt/beta-catenin transcriptional programs.

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    3. Articles
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      Proteomic screening of glutamatergic mouse brain synaptosomes isolated by fluorescence activated sorting (pages 157–170)

      Christoph Biesemann, Mads Grønborg, Elisa Luquet, Sven P Wichert, Véronique Bernard, Simon R Bungers, Ben Cooper, Frédérique Varoqueaux, Liyi Li, Jennifer A Byrne, Henning Urlaub, Olaf Jahn, Nils Brose and Etienne Herzog

      Version of Record online: 10 JAN 2014 | DOI: 10.1002/embj.201386120

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      A novel Fluorescence Activated Synaptosome Sorting (FASS) approach allows for high-resolution biochemical analyses of specific synapse subpopulations and identification of 163 proteins that are specifically enriched in FASS-sorted synaptosomes.

  4. Corrigendum

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      Mfn2 modulates the UPR and mitochondrial function via repression of PERK (page 171)

      Juan Pablo Muñoz, Saška Ivanova, Jana Sánchez-Wandelmer, Paula Martínez-Cristóbal, Eduard Noguera, Ana Sancho, Angels Díaz-Ramos, María Isabel Hernández-Alvarez, David Sebastián, Caroline Mauvezin, Manuel Palacín and Antonio Zorzano

      Version of Record online: 14 JAN 2014 | DOI: 10.1002/embj.201470050

      This article corrects:

      Mfn2 modulates the UPR and mitochondrial function via repression of PERK

      Vol. 32, Issue 17, 2348–2361, Version of Record online: 6 AUG 2013

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