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The EMBO Journal

Cover image for Vol. 33 Issue 3

3 February 2014

Volume 33, Issue 3

Pages 173–276

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    3. Articles
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      It's not over until the FAT lady sings (pages 173–175)

      Marco J Herold and Andreas Strasser

      Version of Record online: 18 JAN 2014 | DOI: 10.1002/embj.201387542

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      This study identifies the cadherin FAT1 as a novel inhibitor of caspase-8 activation with potential therapeutic value in sensitizing glioblastoma cells towards TRAIL-induced apoptosis.

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      Mec1 and Tel1: an arresting dance of resection (pages 176–178)

      Tracey Beyer and Ted Weinert

      Version of Record online: 22 JAN 2014 | DOI: 10.1002/embj.201387440

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      New work reveals how cells coordinate DNA resection and cell cycle arrest to ensure optimal, homology-directed repair of double strand breaks.

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      Will branch for food–nutrient-dependent tracheal remodeling in Drosophila (pages 179–180)

      Stefanie Marxreiter and Carl S Thummel

      Version of Record online: 18 JAN 2014 | DOI: 10.1002/embj.201387412

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      That nutrient- and oxygen-responsive neurons can drive vascular plasticity establishes a new paradigm of hard-wired changes upon metabolic adaptation.

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      A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis (pages 181–197)

      Dominique Kranz and Michael Boutros

      Version of Record online: 18 JAN 2014 | DOI: 10.1002/embj.201385686

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      Starting from an unbiased screen for modifiers of death receptor-mediated (extrinsic) apoptosis, the cadherin FAT1 is identified as novel inhibitor of Caspase 8 activation.

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      Mec1/ATR regulates the generation of single-stranded DNA that attenuates Tel1/ATM signaling at DNA ends (pages 198–216)

      Michela Clerici, Camilla Trovesi, Alessandro Galbiati, Giovanna Lucchini and Maria Pia Longhese

      Version of Record online: 20 DEC 2013 | DOI: 10.1002/embj.201386041

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      Persistent Tel1 activation upon defective Mec1-dependent resection in yeast interferes with checkpoint adaptation, exemplifying a role for the ATM/ATR switch previously observed in human cells.

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      TopBP1 deficiency impairs V(D)J recombination during lymphocyte development (pages 217–228)

      Jieun Kim, Sung Kyu Lee, Yoon Jeon, Yehyun Kim, Changjin Lee, Sung Ho Jeon, Jaegal Shim, In-Hoo Kim, Seokmann Hong, Nayoung Kim, Ho Lee and Rho Hyun Seong

      Version of Record online: 18 JAN 2014 | DOI: 10.1002/embj.201284316

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      TopBP1 is needed for V(D)J rearrangement during development of B, T and iNKT cells.

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      FGF23 promotes renal calcium reabsorption through the TRPV5 channel (pages 229–246)

      Olena Andrukhova, Alina Smorodchenko, Monika Egerbacher, Carmen Streicher, Ute Zeitz, Regina Goetz, Victoria Shalhoub, Moosa Mohammadi, Elena E Pohl, Beate Lanske and Reinhold G Erben

      Version of Record online: 17 JAN 2014 | DOI: 10.1002/embj.201284188

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      αKlotho acts as a co-receptor for the phosphaturic hormone FGF23 but can also activate TRPV5 channels via altered glycosylation patterns. Similar defects in αKlotho- and FGF23-deficient mice along with FGF23-controlled TRPV5 membrane localization suggest that the former pathway reflects αKlotho's in vivo function in renal calcium reabsorption.

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      Developmental refinement of hair cell synapses tightens the coupling of Ca2+ influx to exocytosis (pages 247–264)

      Aaron B Wong, Mark A Rutherford, Mantas Gabrielaitis, Tina Pangršič, Fabian Göttfert, Thomas Frank, Susann Michanski, Stefan Hell, Fred Wolf, Carolin Wichmann and Tobias Moser

      Version of Record online: 18 JAN 2014 | DOI: 10.1002/embj.201387110

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      Cochlear inner hair cells undergo major refinements during their development from pre-sensory pacemaker to sound transducer resulting in spatial coupling between Ca2+ influx and exocytosis.

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      Dom34-Hbs1 mediated dissociation of inactive 80S ribosomes promotes restart of translation after stress (pages 265–276)

      Antonia M G van den Elzen, Anthony Schuller, Rachel Green and Bertrand Séraphin

      Version of Record online: 14 JAN 2014 | DOI: 10.1002/embj.201386123

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      Stresses such as glucose starvation generate inactive 80S ribosome complexes. Dom34-Hbs1 together with Rli1 actively dissociate and re-activate these complexes, offering a new level of translational control.

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