FGF23 promotes renal calcium reabsorption through the TRPV5 channel (pages 229–246)
Olena Andrukhova, Alina Smorodchenko, Monika Egerbacher, Carmen Streicher, Ute Zeitz, Regina Goetz, Victoria Shalhoub, Moosa Mohammadi, Elena E Pohl, Beate Lanske and Reinhold G Erben
Version of Record online: 17 JAN 2014 | DOI: 10.1002/embj.201284188
αKlotho acts as a co-receptor for the phosphaturic hormone FGF23 but can also activate TRPV5 channels via altered glycosylation patterns. Similar defects in αKlotho- and FGF23-deficient mice along with FGF23-controlled TRPV5 membrane localization suggest that the former pathway reflects αKlotho's in vivo function in renal calcium reabsorption.