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The EMBO Journal

Cover image for Vol. 33 Issue 8

16 April 2014

Volume 33, Issue 8

Pages 781–935

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    3. Reviews
    4. Articles
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      LTP: GluN2B on the go (pages 781–782)

      Lucas Matt and Johannes W Hell

      Version of Record online: 5 MAR 2014 | DOI: 10.1002/embj.201487958

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      Lateral diffusion of neuronal NMDA receptors is important for synaptic long-term potentiation and may be affected in autoimmune disorders.

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      Rad17, the clamp loader that loads more than clamps (pages 783–785)

      Tanya T Paull and Ji-Hoon Lee

      Version of Record online: 11 MAR 2014 | DOI: 10.1002/embj.201488223

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      Best known for its upstream role in ATR kinase signaling, Rad17 gains unexpected new roles in promoting early ATM checkpoint responses to DNA double-strand breaks.

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      SERPINs shelter the endowed migrants in a hostile land (pages 786–787)

      Weilan Ye

      Version of Record online: 11 MAR 2014 | DOI: 10.1002/embj.201488241

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      Metastatic cells have to deploy mechanisms that warrant their survival and growth in target organs. A recent study in Cell unravels serpin's functions that enable cancer cells to initiate brain metastases.

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    3. Reviews
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      Synaptic vesicle recycling: steps and principles (pages 788–822)

      Silvio O Rizzoli

      Version of Record online: 4 MAR 2014 | DOI: 10.1002/embj.201386357

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      Silvio Rizzoli reviews the different steps and mechanisms involved in synaptic vesicle biogenesis and recycling.

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      Role of receptor binding specificity in influenza A virus transmission and pathogenesis (pages 823–841)

      Miranda de Graaf and Ron A M Fouchier

      Version of Record online: 25 MAR 2014 | DOI: 10.1002/embj.201387442

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      Recent cases of humans carrying avian Influenza strains highlight the importance of unraveling the role of virus-receptor interactions in cross-species adaptation. de Graaf and Fouchier review how virus hemagglutinin binding to host receptors governs virus pathogenesis, transmission and host spectrum.

      Corrected by:

      Corrigendum: Role of receptor binding specificity in influenza A virus transmission and pathogenesis

      Vol. 33, Issue 14, 1614, Version of Record online: 18 JUL 2014

  3. Articles

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    3. Reviews
    4. Articles
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      Surface dynamics of GluN2B-NMDA receptors controls plasticity of maturing glutamate synapses (pages 842–861)

      Julien P Dupuis, Laurent Ladépêche, Henrik Seth, Lucie Bard, Juan Varela, Lenka Mikasova, Delphine Bouchet, Véronique Rogemond, Jérôme Honnorat, Eric Hanse and Laurent Groc

      Version of Record online: 3 MAR 2014 | DOI: 10.1002/embj.201386356

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      Long-term potentiation in immature hippocampal neurons requires glutamate receptor lateral diffusion and CaMKII recruitment, a process that can be blocked by autoimmune anti-NMDAR antibodies from patients with neuropsychiatric symptoms.

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      Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks (pages 862–877)

      Qinhong Wang, Michael Goldstein, Peter Alexander, Timothy P Wakeman, Tao Sun, Junjie Feng, Zhenkun Lou, Michael B Kastan and Xiao-Fan Wang

      Version of Record online: 17 FEB 2014 | DOI: 10.1002/embj.201386064

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      The DNA damage sensor protein RAD17 constitutes an unexpected MDC1-independent mechanism for early recruitment of ATM-activating MRN complexes to DNA double-strand breaks.

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      Fip1 regulates mRNA alternative polyadenylation to promote stem cell self-renewal (pages 878–889)

      Brad Lackford, Chengguo Yao, Georgette M Charles, Lingjie Weng, Xiaofeng Zheng, Eun-A Choi, Xiaohui Xie, Ji Wan, Yi Xing, Johannes M Freudenberg, Pengyi Yang, Raja Jothi, Guang Hu and Yongsheng Shi

      Version of Record online: 4 MAR 2014 | DOI: 10.1002/embj.201386537

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      Alternative polyadenylation is an emerging key post-transcriptional regulatory mechanism. The essential role for mRNA 3′ end processing factor Fip1 in stem cell self-renewal and pluripotency reveals the importance of poly(A) site choice.

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      Genome-wide analysis reveals a role for BRCA1 and PALB2 in transcriptional co-activation (pages 890–905)

      Alessandro Gardini, David Baillat, Matteo Cesaroni and Ramin Shiekhattar

      Version of Record online: 3 MAR 2014 | DOI: 10.1002/embj.201385567

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      Two major tumor suppressors bind to and co-regulate highly transcribed genes in breast epithelial cells, including NF-κB targets and retinoic acid-responsive genes.

      Corrected by:

      Corrigendum: Genome-wide analysis reveals a role for BRCA1 and PALB2 in transcriptional co-activation

      Vol. 33, Issue 18, 2134, Version of Record online: 17 SEP 2014

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      miR379–410 cluster miRNAs regulate neurogenesis and neuronal migration by fine-tuning N-cadherin (pages 906–920)

      Luciano Rago, Robert Beattie, Verdon Taylor and Jennifer Winter

      Version of Record online: 10 MAR 2014 | DOI: 10.1002/embj.201386591

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      Members of the miR379–410 miRNA cluster control the proliferation and differentiation of radial glial cells (RGCs) and the migration of cortical neurons by reducing N-cadherin levels in the developing neocortex.

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      Human telomerase specialization for repeat synthesis by unique handling of primer-template duplex (pages 921–935)

      Robert Alexander Wu and Kathleen Collins

      Version of Record online: 11 MAR 2014 | DOI: 10.1002/embj.201387205

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      The telomerase-specific TEN domain emerges as the key for adapting general reverse transcriptase function to multiple telomeric repeat synthesis from short primer-template hybrids.

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