Fip1 regulates mRNA alternative polyadenylation to promote stem cell self-renewal (pages 878–889)
Brad Lackford, Chengguo Yao, Georgette M Charles, Lingjie Weng, Xiaofeng Zheng, Eun-A Choi, Xiaohui Xie, Ji Wan, Yi Xing, Johannes M Freudenberg, Pengyi Yang, Raja Jothi, Guang Hu and Yongsheng Shi
Version of Record online: 4 MAR 2014 | DOI: 10.1002/embj.201386537
Alternative polyadenylation is an emerging key post-transcriptional regulatory mechanism. The essential role for mRNA 3′ end processing factor Fip1 in stem cell self-renewal and pluripotency reveals the importance of poly(A) site choice.