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The EMBO Journal

Cover image for Vol. 33 Issue 9

2 May 2014

Volume 33, Issue 9

Pages 937–1085

  1. Have you seen?

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    3. Reviews
    4. Articles
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      Everything old is new again: (linc)RNAs make proteins! (pages 937–938)

      Stephen M Cohen

      Version of Record online: 9 APR 2014 | DOI: 10.1002/embj.201488303

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      Recent advances in ribosome profiling, combined with computational tools and initial functional validations reveal the existence of numerous small peptides that await future functional characterization.

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      Miro1: New wheels for transferring mitochondria (pages 939–941)

      Guy Las and Orian S Shirihai

      Version of Record online: 7 APR 2014 | DOI: 10.1002/embj.201488441

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      The mitochondrial Rho-GTPase Miro1 regulates intercellular mitochondrial transfer between mesenchymal stem cells and epithelial cells in different models of epithelial lung injury.

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      Transcription and processing: multilayer controls of RNA biogenesis by the Hippo pathway (pages 942–944)

      Fa-Xing Yu and Kun-Liang Guan

      Version of Record online: 17 MAR 2014 | DOI: 10.1002/embj.201488329

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      A recent study published in Cell uncovers an entirely novel layer of Hippo signaling: direct regulation of miRNA processing to control global miRNA biogenesis.

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      Epigenetic memory: the Lamarckian brain (pages 945–967)

      Andre Fischer

      Version of Record online: 9 APR 2014 | DOI: 10.1002/embj.201387637

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      As part of our review series on Molecular Memory, Andre Fischer discusses epigenetic processes leading to memory formation and transgenerational inheritance under physiological and pathological conditions such as Alzheimer's disease.

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      Traffic into silence: endomembranes and post-transcriptional RNA silencing (pages 968–980)

      Yun Ju Kim, Alexis Maizel and Xuemei Chen

      Version of Record online: 25 MAR 2014 | DOI: 10.1002/embj.201387262

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      While extensive work has gone into clarifying the mechanistic basis for RNA silencing, our understanding of the cellular compartments involved is still in its infancy. This review discusses accumulating evidence that the endomembrane system plays a central role in orchestrating small RNA pathways.

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      Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation (pages 981–993)

      Ariel A Bazzini, Timothy G Johnstone, Romain Christiano, Sebastian D Mackowiak, Benedikt Obermayer, Elizabeth S Fleming, Charles E Vejnar, Miler T Lee, Nikolaus Rajewsky, Tobias C Walther and Antonio J Giraldez

      Version of Record online: 4 APR 2014 | DOI: 10.1002/embj.201488411

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      The combination of ORFscore and micPDP enable high confidence prediction of many, small translated ORFs that were functionally not appreciated or previously annotated as lincRNAs.

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      Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy (pages 994–1010)

      Tanveer Ahmad, Shravani Mukherjee, Bijay Pattnaik, Manish Kumar, Suchita Singh, Manish Kumar, Rakhshinda Rehman, Brijendra K Tiwari, Kumar A Jha, Amruta P Barhanpurkar, Mohan R Wani, Soumya S Roy, Ulaganathan Mabalirajan, Balaram Ghosh and Anurag Agrawal

      Version of Record online: 15 JAN 2014 | DOI: 10.1002/embj.201386030

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      Repair of injured epithelial cells in mouse models of airway injury and asthma is promoted by transfer of mitochondria from mesenchymal stem cells, facilitated by the mitochondrial Rho-GTPase Miro1.

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      Loss of the m-AAA protease subunit AFG3L2 causes mitochondrial transport defects and tau hyperphosphorylation (pages 1011–1026)

      Arun Kumar Kondadi, Shuaiyu Wang, Sara Montagner, Nikolay Kladt, Anne Korwitz, Paola Martinelli, David Herholz, Michael J Baker, Astrid C Schauss, Thomas Langer and Elena I Rugarli

      Version of Record online: 28 MAR 2014 | DOI: 10.1002/embj.201387009

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      Impaired axonal transport of mitochondria in the absence of AFG3L2 may explain how its mutation in spinocerebellar ataxia impair neuronal development and survival, and suggests possible therapeutic strategies based on counteracting ROS signaling.

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      Creb coactivators direct anabolic responses and enhance performance of skeletal muscle (pages 1027–1043)

      Nelson E Bruno, Kimberly A Kelly, Richard Hawkins, Mariam Bramah-Lawani, Antonio L Amelio, Jerome C Nwachukwu, Kendall W Nettles and Michael D Conkright

      Version of Record online: 27 MAR 2014 | DOI: 10.1002/embj.201386145

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      The sympathetic nervous system coordinates catabolism of energy stores during exercise with anabolic responses post-exercise by activating the Crtc/Creb transcriptional complex.

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      Regulation of a transcription factor network by Cdk1 coordinates late cell cycle gene expression (pages 1044–1060)

      Benjamin D Landry, Claudine E Mapa, Heather E Arsenault, Kristin E Poti and Jennifer A Benanti

      Version of Record online: 8 APR 2014 | DOI: 10.1002/embj.201386877

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      In yeast, Cdk1-dependent phosphorylation regulates several conserved transcription factors positively and/or negatively, which is important for cell cycle progression and optimal fitness.

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      Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates (pages 1061–1072)

      Gwang Hyeon Gwon, Aera Jo, Kyuwon Baek, Kyeong Sik Jin, Yaoyao Fu, Jong-Bong Lee, YoungChang Kim and Yunje Cho

      Version of Record online: 14 APR 2014 | DOI: 10.1002/embj.201487820

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      Co-crystallization of human Mus81-Eme1 bound to flap DNA substrates reveals key structural features essential for substrate selection and active site positioning during resolution of recombination intermediates.

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      GTP hydrolysis by EF-G synchronizes tRNA movement on small and large ribosomal subunits (pages 1073–1085)

      Wolf Holtkamp, Carlos E Cunha, Frank Peske, Andrey L Konevega, Wolfgang Wintermeyer and Marina V Rodnina

      Version of Record online: 10 MAR 2014 | DOI: 10.1002/embj.201387465

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      A new dual-color labeling approach yields dynamic insight on synchronous tRNA movement on both ribosomal subunits and shows that GTP hydrolysis by the translocation factor EF-G drives rearrangement of the 30S subunit.

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