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The EMBO Journal

Cover image for Vol. 29 Issue 24

December 15, 2010

Volume 29, Issue 24

Pages 4063–4237

  1. Have you seen?

    1. Top of page
    2. Have you seen?
    3. EMBO Member's Review
    4. Article
    5. Corrigendum
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      C/EBPδ: friend or foe? A novel role for C/EBPδ in metastasis (pages 4063–4065)

      Facundo G Pelorosso and Allan Balmain

      Version of Record online: 15 DEC 2010 | DOI: 10.1038/emboj.2010.308

      This issue of The EMBO Journal features opposing functions of the assumed tumour suppressor C/EBPδ shown here to promote tumour metastasis. Mechanistically, C/EBPδ amplifies HIF-1α signalling, thus integrating hypoxic inflammation with tumour metastasis.

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      More than one way to make a tail (pages 4066–4067)

      William F Marzluff

      Version of Record online: 15 DEC 2010 | DOI: 10.1038/emboj.2010.306

      The 3′UTR in mRNAs plays an important role in regulating the expression of the corresponding transcripts. Here Bill Marzluff highlights work from the Anderson lab that describes an unexpected active role for a non-canonical poly(A) polymerase in regulating 3′ end cleavage and polyadenylation of specific stress responsive transcripts.

      Corrected by:

      Corrigendum: More than one way to make a tail

      Vol. 30, Issue 3, 628, Version of Record online: 2 FEB 2011

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      Nuclear FoxO1 inflames insulin resistance (pages 4068–4069)

      John E Dominy and Pere Puigserver

      Version of Record online: 15 DEC 2010 | DOI: 10.1038/emboj.2010.305

      FoxO1 regulates the transcription of genes involved in diabetes, cancer and ageing. In this issue of The EMBO Journal, Olefsky and colleagues report that FoxO1 also causes inflammation by regulating the pro-inflammatory Tlr4 signalling pathway in macrophages. Insulin-mediated activation of Akt inactivates FoxO1 and thereby limits the inflammatory response.

  2. EMBO Member's Review

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    3. EMBO Member's Review
    4. Article
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      Kinetochore–microtubule interactions: steps towards bi-orientation (pages 4070–4082)

      Tomoyuki U Tanaka

      Version of Record online: 23 NOV 2010 | DOI: 10.1038/emboj.2010.294

      Our understanding of the intricate molecular events leading to proper chromosome attachments on mitotic spindles and subsequent equal segregation has been greatly advanced in recent years, progress that is summarized in this EMBO Member's Review from Tomoyuki Tanaka.

  3. Article

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    3. EMBO Member's Review
    4. Article
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      Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p (pages 4083–4093)

      Yasuhiko Sato, Hiroyuki Shibata, Toru Nakatsu, Hiroaki Nakano, Yoshinori Kashiwayama, Tsuneo Imanaka and Hiroaki Kato

      Version of Record online: 19 NOV 2010 | DOI: 10.1038/emboj.2010.293

      Post-translational targeting of peroxisomal membrane proteins involves the interaction of the cytosolic receptor and chaperone Pex19p with its docking protein Pex3p at the peroxisomal membrane. This study presents the crystal structure of the cytosolic domain of Pex3p in complex with a Pex19p peptide.

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      Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells (pages 4094–4105)

      Marie Silhankova, Fillip Port, Martin Harterink, Konrad Basler and Hendrik C Korswagen

      Version of Record online: 12 NOV 2010 | DOI: 10.1038/emboj.2010.278

      This paper identifies the myotubularin lipid-phosphatases MTM-6/9 to be important for MIG-14/Wntless recycling, establishing them as novel and essential components for Wnt signalling.

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      The tumour suppressor C/EBPδ inhibits FBXW7 expression and promotes mammary tumour metastasis (pages 4106–4117)

      Kuppusamy Balamurugan, Ju-Ming Wang, Hsin-Hwa Tsai, Shikha Sharan, Miriam Anver, Robert Leighty and Esta Sterneck

      Version of Record online: 12 NOV 2010 | DOI: 10.1038/emboj.2010.280

      This paper reveals a tumour-promoting function of the candidate tumour suppressor CCAAT/enhancer-binding protein-δ. Identification of F-box and WD repeat-domain containing 7 protein as CCAAT/enhancer-binding protein-δ target links hypoxic inflammation and tumour metastasis via mammalian target of rapamycin-mediated hypoxia-inducible factor-1α stabilization.

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      ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3−/− mice (pages 4118–4131)

      Safak Yalcin, Dragan Marinkovic, Sathish Kumar Mungamuri, Xin Zhang, Wei Tong, Rani Sellers and Saghi Ghaffari

      Version of Record online: 26 NOV 2010 | DOI: 10.1038/emboj.2010.292

      This work reports a novel myeloid progenitor phenotype in Foxo3a-deficient mice that exhibit increased reactive oxygen species signalling and reduced expression of Lnk, a negative regulator of mitogenic cytokine signalling. Thus, the paper unveils a molecular link from Foxo3a deficiency to malignant progression.

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      The poly A polymerase Star-PAP controls 3′-end cleavage by promoting CPSF interaction and specificity toward the pre-mRNA (pages 4132–4145)

      Rakesh S Laishram and Richard A Anderson

      Version of Record online: 19 NOV 2010 | DOI: 10.1038/emboj.2010.287

      The classical view of mRNA 3′-end processing involves the recruitment of the poly (A) polymerase by RNA-binding proteins. Here, a variant poly (A) polymerase, Star-PAP, contributes towards substrate specificity of some mRNAs by recruiting the CPSF complex involved in mRNA cleavage.

    6. You have full text access to this OnlineOpen article
      Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing (pages 4146–4160)

      Eric Huntzinger, Joerg E Braun, Susanne Heimstädt, Latifa Zekri and Elisa Izaurralde

      Version of Record online: 9 NOV 2010 | DOI: 10.1038/emboj.2010.274

      Previous studies have suggested that the mechanism of miRNA-mediated silencing may differ between human and Drosophila cells. Here, a direct comparison demonstrates that the mechanism is conserved and the GW182–PABP interaction is required for silencing in vivo.

    7. You have full text access to this OnlineOpen article
      Nol9 is a novel polynucleotide 5′-kinase involved in ribosomal RNA processing (pages 4161–4171)

      Katrin Heindl and Javier Martinez

      Version of Record online: 9 NOV 2010 | DOI: 10.1038/emboj.2010.275

      The production and processing of ribosomal RNA is an essential and complex process. Here, a polynucleotide 5′-kinase, Nol9, is shown to have an important function in pre-rRNA processing and 60S ribosomal subunit biogenesis.

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      Functional organization of the Sm core in the crystal structure of human U1 snRNP (pages 4172–4184)

      Gert Weber, Simon Trowitzsch, Berthold Kastner, Reinhard Lührmann and Markus C Wahl

      Version of Record online: 26 NOV 2010 | DOI: 10.1038/emboj.2010.295

      The U1 small nuclear ribonucleoprotein initiates the assembly of the spliceosome. Here, the structure of the natively purified U1 small nuclear ribonucleoprotein particle reveals the core Sm protein ring and its interactions with the Sm site in the small nuclear RNA.

    9. You have full text access to this OnlineOpen article
      Recycling of peroxiredoxin IV provides a novel pathway for disulphide formation in the endoplasmic reticulum (pages 4185–4197)

      Timothy J Tavender, Jennifer J Springate and Neil J Bulleid

      Version of Record online: 5 NOV 2010 | DOI: 10.1038/emboj.2010.273

      Ero1 is thought to be the only oxidase that mediates the re-oxidation of protein disulphide isomerases (PDIs) during oxidative protein folding in the ER. This study reveals that peroxiredoxin IV can also directly oxidize PDI-family members and thus act as a second source of oxidizing equivalents for disulphide-bond formation in the ER.

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      c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling (pages 4198–4209)

      Jasmin N Dynek, Tatiana Goncharov, Erin C Dueber, Anna V Fedorova, Anita Izrael-Tomasevic, Lilian Phu, Elizabeth Helgason, Wayne J Fairbrother, Kurt Deshayes, Donald S Kirkpatrick and Domagoj Vucic

      Version of Record online: 26 NOV 2010 | DOI: 10.1038/emboj.2010.300

      Canonical Lys48- and Lys63-linked as well as non-canonical linear polyubiquitin chains are involved in receptor-mediated NF-κB activation. This study identifies c-IAP1-generated Lys11-linked chains, so far implicated only in cell-cycle control and proteasome targeting, as an additional signal in this pathway.

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      RNAi-based screening identifies the Mms22L–Nfkbil2 complex as a novel regulator of DNA replication in human cells (pages 4210–4222)

      Wojciech Piwko, Michael H Olma, Michael Held, Julien N Bianco, Patrick G A Pedrioli, Kay Hofmann, Philippe Pasero, Daniel W Gerlich and Matthias Peter

      Version of Record online: 26 NOV 2010 | DOI: 10.1038/emboj.2010.304

      A state-of-the-art microscopy-based RNAi screen for potential cell cycle roles of human DNA damage-binding 1–Cul4-associated factors, substrate adaptors associated with DDB1-cullin 4-based ubiquitin ligases, reveals a homologue of the yeast genome stability factor Mms22 to be required for DNA replication. Interestingly, human Mms22-like protein appears not to be a subunit, but rather a substrate, of the cullin 4 complex.

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      FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages (pages 4223–4236)

      WuQiang Fan, Hidetaka Morinaga, Jane J Kim, Eunju Bae, Nathanael J Spann, Sven Heinz, Christopher K Glass and Jerrold M Olefsky

      Version of Record online: 2 NOV 2010 | DOI: 10.1038/emboj.2010.268

      The transcriptional regulator FoxO1 promotes inflammation by regulating TLR4-mediated signalling in macrophages. TLR4 activation as well as insulin signalling inactivates FoxO1, thereby limiting the inflammatory response.

  4. Corrigendum

    1. Top of page
    2. Have you seen?
    3. EMBO Member's Review
    4. Article
    5. Corrigendum
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      Classifying chemoreceptors: quantity versus quality (page 4237)

      Eric S Underbakke and Laura L Kiessling

      Version of Record online: 26 NOV 2010 | DOI: 10.1038/emboj.2010.303

      This article corrects:

      Classifying chemoreceptors: quantity versus quality

      Vol. 29, Issue 20, 3435–3436, Version of Record online: 20 OCT 2010

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