c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling (pages 4198–4209)
Jasmin N Dynek, Tatiana Goncharov, Erin C Dueber, Anna V Fedorova, Anita Izrael-Tomasevic, Lilian Phu, Elizabeth Helgason, Wayne J Fairbrother, Kurt Deshayes, Donald S Kirkpatrick and Domagoj Vucic
Article first published online: 26 NOV 2010 | DOI: 10.1038/emboj.2010.300
Canonical Lys48- and Lys63-linked as well as non-canonical linear polyubiquitin chains are involved in receptor-mediated NF-κB activation. This study identifies c-IAP1-generated Lys11-linked chains, so far implicated only in cell-cycle control and proteasome targeting, as an additional signal in this pathway.