APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP (pages 2266–2280)
Sascha W Weyer, Maja Klevanski, Andrea Delekate, Vootele Voikar, Dorothee Aydin, Meike Hick, Mikhail Filippov, Natalia Drost, Kristin L Schaller, Martina Saar, Miriam A Vogt, Peter Gass, Ayan Samanta, Andres Jäschke, Martin Korte, David P Wolfer, John H Caldwell and Ulrike C Müller
Version of Record online: 26 APR 2011 | DOI: 10.1038/emboj.2011.119
The in vivo function of the amyloid precursor protein (APP) and its related homologue APLP2 in the adult nervous system is not resolved. Here, the findings show that APLP2 and APP are required to mediate neuromuscular transmission, spatial learning, and synaptic plasticity.