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The EMBO Journal

Cover image for Vol. 30 Issue 12

June 15, 2011

Volume 30, Issue 12

Pages 2307–2511

  1. Have you seen?

    1. Top of page
    2. Have you seen?
    3. Medal Review
    4. Article
    5. Corrigendum
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      Actin up for Hippo (pages 2307–2309)

      Helena E Richardson

      Article first published online: 2 JUN 2010 | DOI: 10.1038/emboj.2011.174

      Papers in this issue of The EMBO Journal and just published in Development report that apical filamentous (F)-actin regulates Hippo pathway activity. Here, the findings of these papers are discussed in the broader context of organ growth and mechano-transduction.

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      X inactivation: a histone protects from reprogramming by the frog (pages 2310–2311)

      Anton Wutz

      Article first published online: 2 JUN 2010 | DOI: 10.1038/emboj.2011.172

      This issue of The EMBO Journal features very interesting work on the macroH2A1 as determinant of pluripotency/reprogramming capability of epiblast stem cells.

  2. Medal Review

    1. Top of page
    2. Have you seen?
    3. Medal Review
    4. Article
    5. Corrigendum
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      Reprogramming the genetic code (pages 2312–2324)

      Jason W Chin

      Article first published online: 20 MAY 2011 | DOI: 10.1038/emboj.2011.160

      In this essay, Jason Chin gives an account of his career and of the seminal works on reprogramming translation to generate custom-modified proteins that has gained him the EMBO Gold Medal 2010.

  3. Article

    1. Top of page
    2. Have you seen?
    3. Medal Review
    4. Article
    5. Corrigendum
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      Modulating F-actin organization induces organ growth by affecting the Hippo pathway (pages 2325–2335)

      Leticia Sansores-Garcia, Wouter Bossuyt, Ken-Ichi Wada, Shigenobu Yonemura, Chunyao Tao, Hiroshi Sasaki and Georg Halder

      Article first published online: 10 MAY 2011 | DOI: 10.1038/emboj.2011.157

      This study identifies actin organization as an upstream regulator of the Hippo pathway: F-actin accumulation promotes Yorkie-dependent transcriptional activation. This modulation of Hippo signalling by actin regulators controls organ growth in Drosophila.

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      The oligomeric state sets GABAB receptor signalling efficacy (pages 2336–2349)

      Laëtitia Comps-Agrar, Julie Kniazeff, Lenea Nørskov-Lauritsen, Damien Maurel, Martin Gassmann, Nathalie Gregor, Laurent Prézeau, Bernhard Bettler, Thierry Durroux, Eric Trinquet and Jean-Philippe Pin

      Article first published online: 6 MAY 2011 | DOI: 10.1038/emboj.2011.143

      This paper adds to the complexity of GPCR signalling, revealing hetero-tetramer formation for native GABAB receptors in brain tissue. An elegant mutational approach further reveals functionally relevant negative cooperativity between GABAB heterodimers.

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      AT1R–CB1R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II (pages 2350–2363)

      Raphael Rozenfeld, Achla Gupta, Khatuna Gagnidze, Maribel P Lim, Ivone Gomes, Dinah Lee-Ramos, Natalia Nieto and Lakshmi A Devi

      Article first published online: 3 MAY 2011 | DOI: 10.1038/emboj.2011.139

      Heterodimerization of the angiotensin receptor (AT1R) with type I cannabinoid receptor (CB1R) enhances angiotensin II-mediated signalling.

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      The RSC chromatin remodelling ATPase translocates DNA with high force and small step size (pages 2364–2372)

      George Sirinakis, Cedric R Clapier, Ying Gao, Ramya Viswanathan, Bradley R Cairns and Yongli Zhang

      Article first published online: 6 MAY 2011 | DOI: 10.1038/emboj.2011.141

      This single-molecule study of the catalytic core of the RSC complex demonstrates that the RSC translocase is capable of moving against higher forces than previously measured and induces DNA distortion during the remodelling reaction.

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      Histone variant macroH2A confers resistance to nuclear reprogramming (pages 2373–2387)

      Vincent Pasque, Astrid Gillich, Nigel Garrett and John B Gurdon

      Article first published online: 6 MAY 2011 | DOI: 10.1038/emboj.2011.144

      Gurdon and collaborators report reversible X chromosome inactivation in epiblast stem cells (EpiSCs) that seems to be determined by macroH2A1 deposition. These findings are of rather general interest as they highlight the epigenetic state of repressed loci as determinant for reprogramming efficiency.

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      The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells (pages 2388–2404)

      Shane McManus, Anja Ebert, Giorgia Salvagiotto, Jasna Medvedovic, Qiong Sun, Ido Tamir, Markus Jaritz, Hiromi Tagoh and Meinrad Busslinger

      Article first published online: 6 MAY 2011 | DOI: 10.1038/emboj.2011.140

      The mechanism of Pax5-mediated gene activation and repression during early B-cell development is unclear. This study identifies Pax5-binding sites in pro-B cells and the changes in chromatin modifications induced by the recruitment of chromatin-modifying and transcription factors.

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      Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth (pages 2405–2419)

      Zhong Chen, Chunpeng Zhang, Dayong Wu, Hongyan Chen, Anna Rorick, Xiaoting Zhang and Qianben Wang

      Article first published online: 10 MAY 2011 | DOI: 10.1038/emboj.2011.154

      This manuscript describes the regulatory network that governs expression of the oncogenic ubiquitin-ligase UBE2C by the Mediator complex in prostate cancer cells. The results on Med1 phosphorylation required for enhancer looping and subsequent expression of the UBE2C offer important insight with potential therapeutic relevance.

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      Box C/D snoRNP catalysed methylation is aided by additional pre-rRNA base-pairing (pages 2420–2430)

      Robert Willem van Nues, Sander Granneman, Grzegorz Kudla, Katherine Elizabeth Sloan, Matthew Chicken, David Tollervey and Nicholas James Watkins

      Article first published online: 10 MAY 2011 | DOI: 10.1038/emboj.2011.148

      Box C/D small nucleolar RNPs catalyse 2′-O-methylation of eukaryotic ribosomal RNA. A large-scale analysis of yeast box C/D snoRNAs reveals conserved ‘extra base-pairing’ between snoRNAs and regions adjacent to their rRNA methylation site and points to a role for the non-catalytic protein subunits Nop56 and Nop58 in rRNA binding.

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      RNA polymerase II kinetics in polo polyadenylation signal selection (pages 2431–2444)

      Pedro A B Pinto, Telmo Henriques, Marta O Freitas, Torcato Martins, Rita G Domingues, Paulina S Wyrzykowska, Paula A Coelho, Alexandre M Carmo, Claudio E Sunkel, Nicholas J Proudfoot and Alexandra Moreira

      Article first published online: 20 MAY 2011 | DOI: 10.1038/emboj.2011.156

      In almost all cases, the biological importance of alternative poly(A) site usage is not clear. Here, the selection of the correct polo poly(A) site choice is of physiological importance and poly(A) choice can be influenced by the elongation rate of the RNA polymerase.

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      The 2′-OH group of the peptidyl-tRNA stabilizes an active conformation of the ribosomal PTC (pages 2445–2453)

      Hani S Zaher, Jeffrey J Shaw, Scott A Strobel and Rachel Green

      Article first published online: 6 MAY 2011 | DOI: 10.1038/emboj.2011.142

      This study re-evaluates and reconciles conflicting reports on the role of the A76 ribose 2′-OH group of P site bound peptidyl-tRNA on peptide-bond formation at the ribosome.

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      eIF2A mediates translation of hepatitis C viral mRNA under stress conditions (pages 2454–2464)

      Joon Hyun Kim, Sung Mi Park, Ji Hoon Park, Sun Ju Keum and Sung Key Jang

      Article first published online: 10 MAY 2011 | DOI: 10.1038/emboj.2011.146

      Under stress conditions, global mRNA translation is suppressed due to phosphorylation of the eukaryotic translation initiation factor 2 (eIF2). Hepatitis C virus mRNA can still be translated under these conditions via a mechanism that involves eIF2A, an alternative initiator tRNA-binding protein

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      Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling (pages 2465–2476)

      Hee Jae Yun, Je-Hyun Yoon, Jae Keun Lee, Kyung-Tae Noh, Kyoung-Wan Yoon, Sang Phil Oh, Hyun Jung Oh, Ji Soo Chae, Sang Gil Hwang, Eun Hee Kim, Gerd G Maul, Dae-Sik Lim and Eui-Ju Choi

      Article first published online: 13 MAY 2011 | DOI: 10.1038/emboj.2011.152

      The Hippo/MST signalling pathway is a key mediator of activation-induced cell death (AICD) in microglia.

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      Skeletal myosin light chain kinase regulates skeletal myogenesis by phosphorylation of MEF2C (pages 2477–2489)

      Ashraf Said Al Madhoun, Virja Mehta, Grace Li, Daniel Figeys, Nadine Wiper-Bergeron and Ilona S Skerjanc

      Article first published online: 10 MAY 2011 | DOI: 10.1038/emboj.2011.153

      Phosphorylation of the critical myogenic transcription factor MEF2C by skeletal MLCK promotes the recruitment of histone acetyltransferases to MEF2C-responsive promoters, thus regulating skeletal muscle gene expression and myoblast differentiation.

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      Nogo-B receptor is necessary for cellular dolichol biosynthesis and protein N-glycosylation (pages 2490–2500)

      Kenneth D Harrison, Eon Joo Park, Ningguo Gao, Andrew Kuo, Jeffrey S Rush, Charles J Waechter, Mark A Lehrman and William C Sessa

      Article first published online: 13 MAY 2011 | DOI: 10.1038/emboj.2011.147

      cis-Isoprenyltransferase (hCIT) is required for the biosynthesis of dolichol monophosphate (Dol-P), the glycosyl carrier lipid that is involved in many protein glycosylation reactions. This study identifies Nogo-B receptor (NgBR) as an interaction partner for hCIT and as an essential component of the Dol-P biosynthetic machinery.

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      APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant (pages 2501–2509)

      Robert Tamayev, Shuji Matsuda, Luca Giliberto, Ottavio Arancio and Luciano D'Adamio

      Article first published online: 17 MAY 2011 | DOI: 10.1038/emboj.2011.161

      A dominant mutation in BRI2 causes familial Danish dementia (FDD). A transgenic mouse model supports the hypothesis that FDD pathogenesis is mediated, like familial Alzheimer disease, via toxic APP products.

  4. Corrigendum

    1. Top of page
    2. Have you seen?
    3. Medal Review
    4. Article
    5. Corrigendum
    1. You have free access to this content
      Interkinetic nuclear migration: cell cycle on the move (page 2510)

      Filippo Del Bene

      Article first published online: 2 JUN 2010 | DOI: 10.1038/emboj.2011.183

      This article corrects:

      Interkinetic nuclear migration: cell cycle on the move

      Vol. 30, Issue 9, 1676–1677, Article first published online: 2 JUN 2010

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      AMPK and autophagy get connected (page 2511)

      D Grahame Hardie

      Article first published online: 2 JUN 2010 | DOI: 10.1038/emboj.2011.175

      This article corrects:

      AMPK and autophagy get connected

      Vol. 30, Issue 4, 634–635, Article first published online: 16 FEB 2011

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