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The EMBO Journal

Cover image for Vol. 30 Issue 13

July 6, 2011

Volume 30, Issue 13

Pages 2513–2750

  1. Have you seen?

    1. Top of page
    2. Have you seen?
    3. EMBO Member's Review
    4. Article
    5. Corrigendum
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      Arresting times for PTEN (pages 2513–2515)

      Miles D Houslay

      Version of Record online: 6 JUL 2011 | DOI: 10.1038/emboj.2011.200

      A novel interaction between PTEN and arrestins, functionally determining the biological role of PTEN in cellular proliferation and migration is featured in the current issue of The EMBO Journal.

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      From DNA binding to metabolic control: integration of -omics data reveals drug targets for prostate cancer (pages 2516–2517)

      Hui Gao and Karin Dahlman-Wright

      Version of Record online: 6 JUL 2011 | DOI: 10.1038/emboj.2011.205

      This highlight discusses how integrated -omics approaches can reveal critical regulatory factors and putative drug targets in cancers, in this case identifying the metabolic regulator CAMKK2 as a direct target of androgen receptor in prostate cancer.

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      Understanding cargo specificity in intraflagellar transport (pages 2518–2519)

      David S Parker and Nicholas Katsanis

      Version of Record online: 6 JUL 2011 | DOI: 10.1038/emboj.2011.196

      Intraflagellar transport (IFT) is essential for cilia biogenesis and maintenance. This demands functional coordination with selective, cell-type-specific cargo transport. A new study published in The EMBO Journal determines molecular and functional interactions between IFT components and transported cargo proteins that might impact on cilia-related diseases.

  2. EMBO Member's Review

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    3. EMBO Member's Review
    4. Article
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      Cellular stress response pathways and ageing: intricate molecular relationships (pages 2520–2531)

      Nikos Kourtis and Nektarios Tavernarakis

      Version of Record online: 17 MAY 2011 | DOI: 10.1038/emboj.2011.162

      In this New EMBO Member's review, Nektarios Tavernarakis discusses the intimate relationship between stress responses and ageing and illustrates how the ability of the organism to deal with intrinsic and extrinsic stress influences longevity.

  3. Article

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    3. EMBO Member's Review
    4. Article
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      Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos (pages 2532–2544)

      Chengtian Zhao and Jarema Malicki

      Version of Record online: 20 MAY 2011 | DOI: 10.1038/emboj.2011.165

      This manuscript offers insight into the molecular networks that govern ciliary localization of Nephrocystin 2. It further reveals functional interactions of IFT components (interflagellar ciliary transport) and ciliopathy-associated proteins in ciliary cargo transport using zebrafish as tractable model.

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      Presequence-dependent folding ensures MrpL32 processing by the m-AAA protease in mitochondria (pages 2545–2556)

      Florian Bonn, Takashi Tatsuta, Carmelina Petrungaro, Jan Riemer and Thomas Langer

      Version of Record online: 24 MAY 2011 | DOI: 10.1038/emboj.2011.169

      The mitochondrial ribosomal subunit Mrp32L requires its presequence for proper folding, so cannot be processed via co-translocational cleavage. Instead, the AAA protease begins to degrade it from the N-terminus. Its activity is halted by a redox-sensitive tightly folded domain, releasing the mature protein.

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      Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins (pages 2557–2568)

      Evelyne Lima-Fernandes, Hervé Enslen, Emeline Camand, Larissa Kotelevets, Cédric Boularan, Lamia Achour, Alexandre Benmerah, Lucien C D Gibson, George S Baillie, Julie A Pitcher, Eric Chastre, Sandrine Etienne-Manneville, Stefano Marullo and Mark G H Scott

      Version of Record online: 3 JUN 2011 | DOI: 10.1038/emboj.2011.178

      This paper discovers β-arrestins as novel binding partner for PTEN. With functional implications for Rho and AKT signalling, the paper adds new insight into the regulation of PTEN by cell surface receptor signalling pathways.

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      AP-2γ regulates oestrogen receptor-mediated long-range chromatin interaction and gene transcription (pages 2569–2581)

      Si Kee Tan, Zhen Hua Lin, Cheng Wei Chang, Vipin Varang, Kern Rei Chng, You Fu Pan, Eu Leong Yong, Wing Kin Sung and Edwin Cheung

      Version of Record online: 13 MAY 2011 | DOI: 10.1038/emboj.2011.151

      It remains unclear how the spatial organization of the genome contributes to gene expression. Here, AP-2 is identified as a new collaborative factor for the oestrogen receptor and it is important for the recruitment of the receptor, FoxA1, long-range genome interactions, and gene transcription.

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      Epigenetically coordinated GATA2 binding is necessary for endothelium-specific endomucin expression (pages 2582–2595)

      Yasuharu Kanki, Takahide Kohro, Shuying Jiang, Shuichi Tsutsumi, Imari Mimura, Jun-ichi Suehiro, Youichiro Wada, Yoshihiro Ohta, Sigeo Ihara, Hiroko Iwanari, Makoto Naito, Takao Hamakubo, Hiroyuki Aburatani, Tatsuhiko Kodama and Takashi Minami

      Version of Record online: 10 JUN 2011 | DOI: 10.1038/emboj.2011.173

      The transcription factor GATA2 regulates developmental cell specification. Genome-wide mapping of chromatin binding shows cell-type specific binding patterns correlating with target gene expression, including activation of an endothelial expression profile. The GATA2 target endomucin regulates endothelial cell growth, migration, and tube formation.

    6. You have full text access to this OnlineOpen article
      The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains (pages 2596–2609)

      Daniel P Ryan, Ramasubramanian Sundaramoorthy, David Martin, Vijender Singh and Tom Owen-Hughes

      Version of Record online: 27 MAY 2011 | DOI: 10.1038/emboj.2011.166

      The large diversity in nucleosome-remodelling enzymes evokes great interest in unveiling common mechanistic themes in remodelling reactions. Here, the C-terminus of Chd1 contains a functionally important DNA-binding domain unexpectedly similar to the SANT and SLIDE domains in the ISWI ATPase.

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      A dual role of H4K16 acetylation in the establishment of yeast silent chromatin (pages 2610–2621)

      Mariano Oppikofer, Stephanie Kueng, Fabrizio Martino, Szabolcs Soeroes, Susan M Hancock, Jason W Chin, Wolfgang Fischle and Susan M Gasser

      Version of Record online: 10 JUN 2011 | DOI: 10.1038/emboj.2011.170

      In budding yeast, silent chromatin is characterized by the binding of the Silent Information Regulatory (Sir) proteins to unmodified nucleosomes. Here, assembly of chromatin using a highly defined in vitro system identifies a dual role for the H4K16Ac modification in silencing by differentially regulating Sir2/Sir4 and Sir3 binding.

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      An RNA–protein complex links enhanced nuclear 3′ processing with cytoplasmic mRNA stabilization (pages 2622–2633)

      Xinjun Ji, Jian Kong and Stephen A Liebhaber

      Version of Record online: 27 MAY 2011 | DOI: 10.1038/emboj.2011.171

      This paper describes that PCBP/αCP protein in addition to its know role in controlling α-globin mRNA stability also regulates 3′ end processing and, therefore, affects the fate of a target mRNA through distinct mechanisms in the nucleus and the cytoplasm.

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      Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5 (pages 2634–2647)

      M Teresa Bertran, Sara Sdelci, Laura Regué, Joseph Avruch, Carme Caelles and Joan Roig

      Version of Record online: 3 JUN 2011 | DOI: 10.1038/emboj.2011.179

      Roig and colleagues elucidate the mechanisms of centrosome separation in mammalian cells. Their work reveals essential contributions of the NIMA kinases Nek6/7 and Nek9 downstream of CDK1–Plk1 activity in mitotic cells.

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      Regulated inactivation of the spindle assembly checkpoint without functional mitotic spindles (pages 2648–2661)

      Colin P De Souza, Shahr B Hashmi, Xiaorui Yang and Stephen A Osmani

      Version of Record online: 3 JUN 2011 | DOI: 10.1038/emboj.2011.176

      In prolonged presence of microtubule drugs, cells occasionally slip out of checkpoint-mediated cell-cycle arrest. Surprisingly, De Souza et al find that the checkpoint in A. nidulans can not only be turned off in an orderly manner, but even cyclically reactivated in the absence of spindles, suggesting its coupling with an underlying autonomous oscillator.

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      Snail1, Snail2, and E47 promote mammary epithelial branching morphogenesis (pages 2662–2674)

      KangAe Lee, Nikolce Gjorevski, Eline Boghaert, Derek C Radisky and Celeste M Nelson

      Version of Record online: 24 MAY 2011 | DOI: 10.1038/emboj.2011.159

      While the roles of Snail transcription factors in epithelial-mesenchymal transition (EMT) are well established, their functions in other morphogenetic processes are less understood. Here, Snail, Snail2, and E47 are shown to promote mammary gland branching morphogenesis, via activation of an EMT-like gene expression program.

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      SCFFBXL15 regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1 (pages 2675–2689)

      Yu Cui, Shan He, Cencan Xing, Kefeng Lu, Jian Wang, Guichun Xing, Anming Meng, Shunji Jia, Fuchu He and Lingqiang Zhang

      Version of Record online: 13 MAY 2011 | DOI: 10.1038/emboj.2011.155

      Zhang et al identify the F-box protein FBXL15 as regulator of the ubiquitin E3 ligase Smurf1. The physiological significance for this interaction is confirmed by BMP-dependent phenotypes in zebrafish embryonic dorsalization and bone mineralization in rat tissue upon FBXL15 knockdown.

    13. You have full text access to this OnlineOpen article
      Id2 expression delineates differential checkpoints in the genetic program of CD8α+ and CD103+ dendritic cell lineages (pages 2690–2704)

      Jacob T Jackson, Yifang Hu, Ruijie Liu, Frederick Masson, Angela D'Amico, Sebastian Carotta, Annie Xin, Mary J Camilleri, Adele M Mount, Axel Kallies, Li Wu, Gordon K Smyth, Stephen L Nutt and Gabrielle T Belz

      Version of Record online: 17 MAY 2011 | DOI: 10.1038/emboj.2011.163

      A novel reporter mouse for the transcription factor inhibitor of DNA binding-2 (Id2) provides insight into the differentiation of DC subsets in vivo and in vitro.

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      A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing (pages 2705–2718)

      Sven Brenner, Diana Drewel, Thomas Steinbart, Florian Weisel, Eric Härtel, Sonja Pötzsch, Heike Welzel, Andreas Brandl, Philipp Yu, Geert C Mudde, Astrid Schweizer, Lars Nitschke and Thomas H Winkler

      Version of Record online: 27 MAY 2011 | DOI: 10.1038/emboj.2011.168

      A novel mouse model supports the hypothesis that BCR signalling strength is important for the development of B-lymphocyte subpopulations.

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      The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis (pages 2719–2733)

      Charles E Massie, Andy Lynch, Antonio Ramos-Montoya, Joan Boren, Rory Stark, Ladan Fazli, Anne Warren, Helen Scott, Basetti Madhu, Naomi Sharma, Helene Bon, Vinny Zecchini, Donna-Michelle Smith, Gina M DeNicola, Nik Mathews, Michelle Osborne, James Hadfield, Stewart MacArthur, Boris Adryan, Scott K Lyons, Kevin M Brindle, John Griffiths, Martin E Gleave, Paul S Rennie, David E Neal and Ian G Mills

      Version of Record online: 20 MAY 2011 | DOI: 10.1038/emboj.2011.158

      Using a combination of genomic and metabolomic profiling strategies, the CAMKK2 kinase is identified as a critical downstream target of the androgen receptor. CAMKK2 regulates anabolic flux, and represents an attractive therapeutic target for prostate cancer treatments.

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      Structural basis of cargo recognition by the myosin-X MyTH4–FERM domain (pages 2734–2747)

      Yoshinori Hirano, Taiki Hatano, Aya Takahashi, Michinori Toriyama, Naoyuki Inagaki and Toshio Hakoshima

      Version of Record online: 3 JUN 2011 | DOI: 10.1038/emboj.2011.177

      Myosin-X is implicated in spindle assembly and filopodial transport. A detailed structure function analysis of the myosin-X tail domain in association with a cargo involved in axonal pathfinding, the netrin receptor DCC and competitive binding to integrin β5 and microtubules is presented.

  4. Corrigendum

    1. Top of page
    2. Have you seen?
    3. EMBO Member's Review
    4. Article
    5. Corrigendum
    1. You have free access to this content
      SCFFBXL15 regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1 (page 2748)

      Yu Cui, Shan He, Cencan Xing, Kefeng Lu, Jian Wang, Guichun Xing, Anming Meng, Shunji Jia, Fuchu He and Lingqiang Zhang

      Version of Record online: 6 JUL 2011 | DOI: 10.1038/emboj.2011.191

      This article corrects:

      SCFFBXL15 regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1

      Vol. 30, Issue 13, 2675–2689, Version of Record online: 13 MAY 2011

    2. You have free access to this content
    3. You have free access to this content
      AP-2γ regulates oestrogen receptor-mediated long-range chromatin interaction and gene transcription (page 2750)

      Si Kee Tan, Zhen Hua Lin, Cheng Wei Chang, Vipin Varang, Kern Rei Chng, You Fu Pan, Eu Leong Yong, Wing Kin Sung and Edwin Cheung

      Version of Record online: 6 JUL 2011 | DOI: 10.1038/emboj.2011.190

      This article corrects:

      AP-2γ regulates oestrogen receptor-mediated long-range chromatin interaction and gene transcription

      Vol. 30, Issue 13, 2569–2581, Version of Record online: 13 MAY 2011

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