A yeast BH3-only protein mediates the mitochondrial pathway of apoptosis (pages 2779–2792)
Sabrina Büttner, Doris Ruli, F-Nora Vögtle, Lorenzo Galluzzi, Barbara Moitzi, Tobias Eisenberg, Oliver Kepp, Lukas Habernig, Didac Carmona-Gutierrez, Patrick Rockenfeller, Peter Laun, Michael Breitenbach, Chamel Khoury, Kai-Uwe Fröhlich, Gerald Rechberger, Chris Meisinger, Guido Kroemer and Frank Madeo
Article first published online: 14 JUN 2011 | DOI: 10.1038/emboj.2011.197
It has been assumed so far that yeast is devoid of BCL-2 family members. This study identifies the yeast BCL-2 homology domain 3 protein Ybh3p that triggers an intrinsic cell death pathway involving the mitochondrial phosphate carrier Mir1p.