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The EMBO Journal

Cover image for Vol. 30 Issue 17

August 31, 2011

Volume 30, Issue 17

Pages 3455–3662

  1. Editorial

    1. Top of page
    2. Editorial
    3. Focus Review
    4. Have you seen?
    5. Article
    6. Corrigendum
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      The five ‘W's of transport (pages 3455–3456)

      Isabel Arnold and Katherine Brown

      Version of Record online: 31 AUG 2011 | DOI: 10.1038/emboj.2011.275

  2. Focus Review

    1. Top of page
    2. Editorial
    3. Focus Review
    4. Have you seen?
    5. Article
    6. Corrigendum
    1. You have free access to this content
      Ran-dependent nuclear export mediators: a structural perspective (pages 3457–3474)

      Thomas Güttler and Dirk Görlich

      Version of Record online: 31 AUG 2011 | DOI: 10.1038/emboj.2011.287

      Diverse import and export complexes mediate transport between the nucleus and cytoplasm. The contribution of structural data to our understanding of the molecular basis underlying specificity and directionality of transport is discussed here.

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      Protein export at the ER: loading big collagens into COPII carriers (pages 3475–3480)

      Vivek Malhotra and Patrik Erlmann

      Version of Record online: 31 AUG 2011 | DOI: 10.1038/emboj.2011.255

      The secretory pathway needs to accommodate many different types and sizes of cargo. As detailed in this review, the molecules and mechanisms that package large cargoes such as collagen for ER exit have recently been uncovered.

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      Endosome maturation (pages 3481–3500)

      Jatta Huotari and Ari Helenius

      Version of Record online: 31 AUG 2011 | DOI: 10.1038/emboj.2011.286

      Many intracellular trafficking events involve endosomes as key sorting hubs. This review considers the processes that drive the maturation of this highly dynamic and versatile organelle.

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      Let's go bananas: revisiting the endocytic BAR code (pages 3501–3515)

      Britta Qualmann, Dennis Koch and Michael Manfred Kessels

      Version of Record online: 31 AUG 2011 | DOI: 10.1038/emboj.2011.266

      Vesicle formation is accompanied by dramatic changes in membrane geometry. The role of the BAR domain proteins in membrane shaping—with a focus on how their structural features are optimized for this function—is explained here.

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      Regulation of developmental intercellular signalling by intracellular trafficking (pages 3516–3526)

      Ben-Zion Shilo and Eyal D Schejter

      Version of Record online: 31 AUG 2011 | DOI: 10.1038/emboj.2011.269

      Metazoan development requires the tight spatio-temporal regulation of intercellular signalling. As reviewed here, this involves multi-layered control of the subcellular localization and trafficking of signal pathway components.

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      Coupling viruses to dynein and kinesin-1 (pages 3527–3539)

      Mark P Dodding and Michael Way

      Version of Record online: 31 AUG 2011 | DOI: 10.1038/emboj.2011.283

      This review discusses how viruses co-opt the microtubule-based transport systems of their host for intracellular trafficking, and highlights the insights viruses have provided into basic mechanisms of cellular bidirectional cargo transport by microtubule motors.

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      Mechanisms of dendritic mRNA transport and its role in synaptic tagging (pages 3540–3552)

      Michael Doyle and Michael A Kiebler

      Version of Record online: 31 AUG 2011 | DOI: 10.1038/emboj.2011.278

      In this review, our understanding of the mechanisms and regulation of dendritic mRNA localization is synthesized into a ‘sushi belt’ model of mRNA transport and translational control in neurons.

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      Intercellular and systemic movement of RNA silencing signals (pages 3553–3563)

      Charles W Melnyk, Attila Molnar and David C Baulcombe

      Version of Record online: 31 AUG 2011 | DOI: 10.1038/emboj.2011.274

      Local small RNA generation can silence gene expression over long distances. Recent progress in our understanding of how these mobile RNA species are transported between cells is described.

  3. Have you seen?

    1. Top of page
    2. Editorial
    3. Focus Review
    4. Have you seen?
    5. Article
    6. Corrigendum
    1. You have free access to this content
      The road not taken: new destinations for yeast mRNAs on the move (pages 3564–3566)

      Soonmoon Yoo and Jeffery L Twiss

      Version of Record online: 31 AUG 2011 | DOI: 10.1038/emboj.2011.282

      Highly specific and precise mechanisms have evolved for transport of mRNAs to subcellular regions in polarized eukaryotic cells. In this issue of The EMBO Journal, Kilchert and Spang (2011) show that yeast ABP140 mRNA is localized through a translation-dependent mechanism.

  4. Article

    1. Top of page
    2. Editorial
    3. Focus Review
    4. Have you seen?
    5. Article
    6. Corrigendum
    1. You have free access to this content
      Cotranslational transport of ABP140 mRNA to the distal pole of S. cerevisiae (pages 3567–3580)

      Cornelia Kilchert and Anne Spang

      Version of Record online: 26 JUL 2011 | DOI: 10.1038/emboj.2011.247

      This study identifies a cotranslational mRNA transport pathway in dividing yeast cells that involves tethering of the translating mRNA of ABP140 to actin cables via its nascent protein product and actin retrograde flow-mediated transport to the distal pole of the mother cell.

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      VCIP135 deubiquitinase and its binding protein, WAC, in p97ATPase-mediated membrane fusion (pages 3581–3593)

      Go Totsukawa, Yayoi Kaneko, Keiji Uchiyama, Hiroyuki Toh, Kaori Tamura and Hisao Kondo

      Version of Record online: 2 AUG 2011 | DOI: 10.1038/emboj.2011.260

      The deubiquitinating enzyme VCIP135 plays an important role in a number of different p97 ATPase-dependent membrane fusion events. This study identifies the protein WAC as a VCIP135 interaction partner that activates its deubiquitination activity and specifically regulates the p97/p47-mediated Golgi membrane fusion pathway.

    3. You have full text access to this OnlineOpen article
      Multiple modalities converge on a common gate to control K2P channel function (pages 3594–3606)

      Sviatoslav N Bagriantsev, Rémi Peyronnet, Kimberly A Clark, Eric Honoré and Daniel L Minor Jr

      Version of Record online: 15 JUL 2011 | DOI: 10.1038/emboj.2011.230

      K2P potassium channels play important roles in the regulation of neuronal excitability. K2P channels are gated chemical, thermal, and mechanical stimuli, and the present study identifies and characterizes a common molecular gate that responds to all different stimuli, both activating and inhibitory ones.

    4. You have full text access to this OnlineOpen article
      The pore structure and gating mechanism of K2P channels (pages 3607–3619)

      Paula L Piechotta, Markus Rapedius, Phillip J Stansfeld, Murali K Bollepalli, Gunter Erhlich, Isabelle Andres-Enguix, Hariolf Fritzenschaft, Niels Decher, Mark S P Sansom, Stephen J Tucker and Thomas Baukrowitz

      Version of Record online: 5 AUG 2011 | DOI: 10.1038/emboj.2011.268

      K2P potassium channels are important regulators of cellular excitability. This study reveals that in contrast to most other K+ channels the primary gating mechanism in the K2P channel TREK-1 does not involve opening and closure of the cytoplasmic bundle crossing, but takes place close to or within the selectivity filter.

    5. You have full text access to this OnlineOpen article
      The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85 (pages 3620–3634)

      Thomas Oellerich, Vanessa Bremes, Konstantin Neumann, Hanibal Bohnenberger, Kai Dittmann, He-Hsuan Hsiao, Michael Engelke, Tim Schnyder, Facundo D Batista, Henning Urlaub and Jürgen Wienands

      Version of Record online: 5 AUG 2011 | DOI: 10.1038/emboj.2011.251

      The Slp65 adaptor molecule is important for B-cell receptor signalling. Here, the interactomes of SLP65 in resting and activated B cells are resolved by mass spectrometry. A number of SLP65 interacting partners, including CIN85, continuously associate with SLP65 in a stimulation-independent manner. CIN85 recruits SLP65 to the membrane and it is required for SLP65 phosphorylation.

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      Jarid2 regulates mouse epidermal stem cell activation and differentiation (pages 3635–3646)

      Stefania Mejetta, Lluis Morey, Gloria Pascual, Bernd Kuebler, Matthew R Mysliwiec, Youngsook Lee, Ramin Shiekhattar, Luciano Di Croce and Salvador Aznar Benitah

      Version of Record online: 2 AUG 2011 | DOI: 10.1038/emboj.2011.265

      This paper analyses the role of Jarid2 during epidermal hair follicle development and adult homeostasis. Although the data suggest Jarid2 to be required for full PRC2-mediated repression in keratinocytes, careful phenotypic analyses reveal further, PRC2-independent functions of Jarid2.

    7. You have full text access to this OnlineOpen article
      Vaccinia extracellular virions enter cells by macropinocytosis and acid-activated membrane rupture (pages 3647–3661)

      Florian Ingo Schmidt, Christopher Karl Ernst Bleck, Ari Helenius and Jason Mercer

      Version of Record online: 26 JUL 2011 | DOI: 10.1038/emboj.2011.245

      Double membrane-bound vaccinia extracellular virions actively promote their own macropinocytosis. This, followed by acid-induced rupture of the outer membrane in endocytic vesicles, exposes the inner membrane for fusion with the endocytic membrane and release into the cytosol.

  5. Corrigendum

    1. Top of page
    2. Editorial
    3. Focus Review
    4. Have you seen?
    5. Article
    6. Corrigendum
    1. You have free access to this content
      Cotranslational transport of ABP140 mRNA to the distal pole of S. cerevisiae (page 3662)

      Cornelia Kilchert and Anne Spang

      Version of Record online: 31 AUG 2011 | DOI: 10.1038/emboj.2011.309

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