microRNA-34c is a novel target to treat dementias (pages 4299–4308)
Athanasios Zovoilis, Hope Y Agbemenyah, Roberto C Agis-Balboa, Roman M Stilling, Dieter Edbauer, Pooja Rao, Laurent Farinelli, Ivana Delalle, Andrea Schmitt, Peter Falkai, Sanaz Bahari-Javan, Susanne Burkhardt, Farahnaz Sananbenesi and Andre Fischer
Version of Record online: 23 SEP 2011 | DOI: 10.1038/emboj.2011.327
The miRNAome of the mouse hippocampus reveals miR-34c as a specific negative regulator of memory formation. miR-34c levels are elevated in a mouse model of Alzheimer's Disease as well as in Alzheimer's patients, and miR-34c inhibition restores memory performance in the animal model.