You have free access to this content

The EMBO Journal

Cover image for Vol. 30 Issue 21

November 2, 2011

Volume 30, Issue 21

Pages 4337–4515

  1. Have you seen?

    1. Top of page
    2. Have you seen?
    3. EMBO Member's Review
    4. Article
    5. Errata
    1. You have free access to this content
      Lipid droplet meets a mitochondrial protein to regulate adipocyte lipolysis (pages 4337–4339)

      Andrew S Greenberg, Fredric B Kraemer, Krishnakant G Soni, Mark P Jedrychowski, Qing-Wu Yan, Christine E Graham, Thomas A Bowman and Ayla Mansur

      Version of Record online: 2 NOV 2011 | DOI: 10.1038/emboj.2011.371

      Optic Atrophy 1 (OPA1) is well known as a regulator of mitochondrial dynamics. Now, a new function of OPA1 is uncovered: recruiting protein kinase A to lipid droplets, thereby controlling the activity of perilipin, and hence lipolysis.

    2. You have free access to this content
      A novel nuclear miRNA mediated modulation of a non-coding antisense RNA and its cognate sense coding mRNA (pages 4340–4341)

      John J Rossi

      Version of Record online: 2 NOV 2011 | DOI: 10.1038/emboj.2011.373

      MicroRNAs control gene expression by inhibition of protein translation and by mRNA degradation. Now, a new mode of action for miRNAs is reported: nuclear-localized miRNAs target non-coding antisense transcripts via the Ago2 slicer complex.

    3. You have free access to this content
      The clasp between NetrinG and NGL becomes crystal clear (pages 4342–4344)

      Jennifer S Goldman and Timothy E Kennedy

      Version of Record online: 2 NOV 2011 | DOI: 10.1038/emboj.2011.375

      The crystal structures of the netrinG/NGL adhesive interactions reveal the mechanism of specificity influencing neural circuit formation, with implications for cognitive disorders.

  2. EMBO Member's Review

    1. Top of page
    2. Have you seen?
    3. EMBO Member's Review
    4. Article
    5. Errata
    1. You have free access to this content
      The complex transcription regulatory landscape of our genome: control in three dimensions (pages 4345–4355)

      Erik Splinter and Wouter de Laat

      Version of Record online: 27 SEP 2011 | DOI: 10.1038/emboj.2011.344

      This review highlights how genomic topology and nuclear spatial organisation govern transcriptional regulation, and how they lead to variegated gene expression.

  3. Article

    1. Top of page
    2. Have you seen?
    3. EMBO Member's Review
    4. Article
    5. Errata
    1. You have free access to this content
      The mitochondrial contact site complex, a determinant of mitochondrial architecture (pages 4356–4370)

      Max Harner, Christian Körner, Dirk Walther, Dejana Mokranjac, Johannes Kaesmacher, Ulrich Welsch, Janice Griffith, Matthias Mann, Fulvio Reggiori and Walter Neupert

      Version of Record online: 18 OCT 2011 | DOI: 10.1038/emboj.2011.379

      The outer and inner mitochondrial membranes are physically linked. Quantitative high resolution mass spectrometry now identifies the molecular nature of the Mitochondrial Contact Site complex (MICOS). MICOS is required for crista junctions formation, respiration and mitochondrial DNA inheritance.

    2. You have free access to this content
      Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis (pages 4371–4386)

      Guillaume Pidoux, Oliwia Witczak, Elisabeth Jarnæss, Linda Myrvold, Henning Urlaub, Anne Jorunn Stokka, Thomas Küntziger and Kjetil Taskén

      Version of Record online: 7 OCT 2011 | DOI: 10.1038/emboj.2011.365

      Adrenergic stimulation of adipoytes induces PKA-dependent phosphorylation of perilipin, the major regulator of lipolysis in lipid droplets. The mitochondrial dynamics regulator Optic Atrophy 1 is the A-kinase anchoring protein on lipid droplets, and is required for the regulation of lipolysis.

    3. You have free access to this content
      A single copy of SecYEG is sufficient for preprotein translocation (pages 4387–4397)

      Alexej Kedrov, Ilja Kusters, Victor V Krasnikov and Arnold J M Driessen

      Version of Record online: 6 SEP 2011 | DOI: 10.1038/emboj.2011.314

      The SecYEG complex is required for the translocation of many bacterial proteins across the inner membrane. Which oligomeric state constitutes the functional translocon is currently controversial. Here, in a fully reconstituted in vitro system, the monomer is shown to be the minimal functional unit.

    4. You have free access to this content
      Orientation-specific signalling by thrombopoietin receptor dimers (pages 4398–4413)

      Judith Staerk, Jean-Philippe Defour, Christian Pecquet, Emilie Leroy, Hélène Antoine-Poirel, Ian Brett, Miki Itaya, Steven O Smith, William Vainchenker and Stefan N Constantinescu

      Version of Record online: 2 SEP 2011 | DOI: 10.1038/emboj.2011.315

      Cytokine receptors dimerize upon ligand binding to transduce extracellular signals. Strikingly, the relative orientation of the two receptor monomers determines the choice of intracellular signalling pathways and physiological outcome.

    5. You have free access to this content
      miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA (pages 4414–4422)

      Thomas B Hansen, Erik D Wiklund, Jesper B Bramsen, Sune B Villadsen, Aaron L Statham, Susan J Clark and Jørgen Kjems

      Version of Record online: 30 SEP 2011 | DOI: 10.1038/emboj.2011.359

      Natural antisense transcripts appear to have widespread roles in gene regulation. This study provides the first example of miRNA targeting of an antisense transcript. Nuclear miR-671 targets and cleaves a circular antisense transcript expressed from the CDR1 locus, reducing CDR1 mRNA levels.

    6. You have free access to this content
      The mechanism of translation initiation on Aichivirus RNA mediated by a novel type of picornavirus IRES (pages 4423–4436)

      Yingpu Yu, Trevor R Sweeney, Panagiota Kafasla, Richard J Jackson, Tatyana V Pestova and Christopher UT Hellen

      Version of Record online: 26 AUG 2011 | DOI: 10.1038/emboj.2011.306

      Picornavirus mRNAs contain internal ribosomal entry sites (IRESs) that mediate translation during infection, when global host protein synthesis is inhibited. Aichi Virus harbours a novel type of IRES that needs the DExH-box helicase DHX29 for function.

    7. You have free access to this content
      Crystal structures of an archaeal class II DNA photolyase and its complex with UV-damaged duplex DNA (pages 4437–4449)

      Stephan Kiontke, Yann Geisselbrecht, Richard Pokorny, Thomas Carell, Alfred Batschauer and Lars-Oliver Essen

      Version of Record online: 2 SEP 2011 | DOI: 10.1038/emboj.2011.313

      The first structural glimpse at this class of light-dependent repair enzymes reveals not only a novel electron transfer mechanism compared to other photolyase/cryptochrome subfamilies, but also how an unrepaired DNA lesion binds to a photolyase active site.

    8. You have full text access to this OnlineOpen article
      Epigenetic silencing of the oncogenic miR-17-92 cluster during PU.1-directed macrophage differentiation (pages 4450–4464)

      Vit Pospisil, Karin Vargova, Juraj Kokavec, Jana Rybarova, Filipp Savvulidi, Anna Jonasova, Emanuel Necas, Jiri Zavadil, Peter Laslo and Tomas Stopka

      Version of Record online: 6 SEP 2011 | DOI: 10.1038/emboj.2011.317

      This study unravels an epigenetic mechanism for the regulation of the oncogenic miRNA cluster 17-92, involving the master hematopoietic transcription factor PU.1/Egr-2 and Jarid1b.

    9. You have free access to this content
      BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response (pages 4465–4478)

      Karen Castillo, Diego Rojas-Rivera, Fernanda Lisbona, Benjamín Caballero, Melissa Nassif, Felipe A Court, Sebastian Schuck, Consuelo Ibar, Peter Walter, Jimena Sierralta, Alvaro Glavic and Claudio Hetz

      Version of Record online: 16 SEP 2011 | DOI: 10.1038/emboj.2011.318

      Bax inhibitor-1 (BI-1) negatively regulates the ER stress sensor IRE1α and promotes cell survival. BI-1 attenuates starvation-induced autophagy, presumably by displacing TRAF2 from IRE1α and interfering with JNK activation.

    10. You have full text access to this OnlineOpen article
      Structural basis for cell surface patterning through NetrinG–NGL interactions (pages 4479–4488)

      Elena Seiradake, Charlotte H Coles, Pavel V Perestenko, Karl Harlos, Robert Andrew Jeffrey McIlhinney, Alexandru Radu Aricescu and Edith Yvonne Jones

      Version of Record online: 23 SEP 2011 | DOI: 10.1038/emboj.2011.346

      NetrinGs and NetrinG-ligands (NGLs) control neuronal circuit development, and their dysregulation is associated with autism and schizophrenia. The first structures of NetrinG-NGL complexes and structure-based functional assays show that binding affinity governs the cell surface compartmentalization of NGLs.

    11. You have free access to this content
      Transcription factor Dlx2 protects from TGFβ-induced cell-cycle arrest and apoptosis (pages 4489–4499)

      Mahmut Yilmaz, Dorothea Maaß, Neha Tiwari, Lorenz Waldmeier, Petra Schmidt, François Lehembre and Gerhard Christofori

      Version of Record online: 6 SEP 2011 | DOI: 10.1038/emboj.2011.319

      Identification of new Dlx2 targets reveal this transcriptional repressor as a potentially important regulator that shifts the balance from TGFb-mediated tumour suppression towards tumour promoting functions.

    12. You have free access to this content
      Signalling pathway for RKIP and Let-7 regulates and predicts metastatic breast cancer (pages 4500–4514)

      Jieun Yun, Casey A Frankenberger, Wen-Liang Kuo, Mirjam C Boelens, Eva M Eves, Nancy Cheng, Han Liang, Wen-Hsiung Li, Hemant Ishwaran, Andy J Minn and Marsha Rich Rosner

      Version of Record online: 26 AUG 2011 | DOI: 10.1038/emboj.2011.312

      RKIP is a metastasis suppressor, acting via the microRNA let-7 to inhibit invasiveness of breast cancer cells. The identification of relevant let-7 target genes defines an RKIP pathway metastasis signature that is predictive of metastatic risk in breast cancer samples.

  4. Errata

    1. Top of page
    2. Have you seen?
    3. EMBO Member's Review
    4. Article
    5. Errata
    1. You have free access to this content
      The pore structure and gating mechanism of K2P channels (page 4515)

      Paula L Piechotta, Markus Rapedius, Phillip J Stansfeld, Murali K Bollepalli, Gunter Ehrlich, Isabelle Andres-Enguix, Hariolf Fritzenschaft, Niels Decher, Mark S P Sansom, Stephen J Tucker and Thomas Baukrowitz

      Version of Record online: 2 NOV 2011 | DOI: 10.1038/emboj.2011.369

      This article corrects:

      The pore structure and gating mechanism of K2P channels

      Vol. 30, Issue 17, 3607–3619, Version of Record online: 5 AUG 2011

SEARCH

SEARCH BY CITATION