Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer (pages 480–493)
Armelle Corpet, Leanne De Koning, Joern Toedling, Alexia Savignoni, Frédérique Berger, Charlène Lemaître, Roderick J O'Sullivan, Jan Karlseder, Emmanuel Barillot, Bernard Asselain, Xavier Sastre-Garau and Geneviève Almouzni
Version of Record online: 21 DEC 2010 | DOI: 10.1038/emboj.2010.335
Anti-silencing function 1 (Asf1) is a H3–H4 chaperone involved in both replication-coupled and replication-independent nucleosome assembly pathways. Here in mammalian cells Asf1b is the physiologically important isoform for cell proliferation and overexpression of Asf1b correlates with prognosis and metastasis status of breast cancer.