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The EMBO Journal

Cover image for Vol. 30 Issue 5

March 2, 2011

Volume 30, Issue 5

Pages 797–982

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      Re-dicing the pancreatic β-cell: do microRNAs define cellular identity? (pages 797–799)

      Sudhir Gopal Tattikota and Matthew N Poy

      Version of Record online: 2 MAR 2011 | DOI: 10.1038/emboj.2011.31

      A role for Dicer and miRNAs in regulating pancreatic β-cell differentiation and insulin production is discussed here in the broader context of miRNA functions in cell fate specification and cellular stress responses.

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      L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1 (pages 800–813)

      Lin Cheng, Qiulian Wu, Zhi Huang, Olga A Guryanova, Qian Huang, Weinian Shou, Jeremy N Rich and Shideng Bao

      Version of Record online: 4 FEB 2011 | DOI: 10.1038/emboj.2011.10

      Radioresistance of glioblastomas has been correlated with increased DNA repair capacities of glioblastoma stem cells. This is now linked to a surface marker of such stem cells, whose radiation-induced intramembrane proteolysis induces expression of a key DNA repair gene.

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      The role of Mediator in small and long noncoding RNA production in Arabidopsis thaliana (pages 814–822)

      Yun Ju Kim, Binglian Zheng, Yu Yu, So Youn Won, Beixin Mo and Xuemei Chen

      Version of Record online: 21 JAN 2011 | DOI: 10.1038/emboj.2011.3

      Mediator is a large multi-subunit complex that is required for the transcription of genes by RNA polymerase II. Here, Mediator also has a role in the transcription of miRNAs in plants and for RNA polymerase V mediated gene silencing.

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      Small RNA-mediated regulation of iPS cell generation (pages 823–834)

      Zhonghan Li, Chao-Shun Yang, Katsuhiko Nakashima and Tariq M Rana

      Version of Record online: 1 FEB 2011 | DOI: 10.1038/emboj.2011.2

      The generation of induced pluripotent stem cells is limited by the low reprogramming efficiency of somatic cells. Here, three clusters of miRNAs are shown to enhance reprogramming efficiency by targeting the TGF-β and p53 pathways, which inhibit the process.

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      miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors (pages 835–845)

      Tal Melkman-Zehavi, Roni Oren, Sharon Kredo-Russo, Tirosh Shapira, Amitai D Mandelbaum, Natalia Rivkin, Tomer Nir, Kim A Lennox, Mark A Behlke, Yuval Dor and Eran Hornstein

      Version of Record online: 1 FEB 2011 | DOI: 10.1038/emboj.2010.361

      A pancreatic β-cell-specific knockout of Dicer with a diabetic phenotype reveals critical roles for specific miRNAs in the regulation of insulin expression.

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      JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress (pages 846–858)

      Juhong Liu, Hye-Jung Chung, Matthew Vogt, Yetao Jin, Daniela Malide, Liusheng He, Miroslav Dundr and David Levens

      Version of Record online: 1 FEB 2011 | DOI: 10.1038/emboj.2011.11

      USP29 joins the family of deubiquitinating enzymes involved in the stabilization of p53. Furthermore, p53 regulation is in this case linked to the c-Myc pathway, whose constituents JTV1 and FBP control USP29 expression upon oxidative stress.

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      Gcn4p-mediated transcriptional repression of ribosomal protein genes under amino-acid starvation (pages 859–872)

      Yoo Jin Joo, Jin-Ha Kim, Un-Beom Kang, Myeong-Hee Yu and Joon Kim

      Version of Record online: 24 DEC 2010 | DOI: 10.1038/emboj.2010.332

      Gcn4p is a major transcriptional activator of amino acid and purine biosynthesis genes, but at the same time acts as a repressor for ribosomal protein (RP) genes. Gcn4 inhibits RP gene transcription by disrupting the interaction between the transcriptional activator Rap1p and the histone acetylase Esa1p.

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      The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A (pages 873–881)

      Madhusudhan Srinivasan, Preeti Mehta, Yao Yu, Evelyn Prugar, Eugene V Koonin, A Wali Karzai and Rolf Sternglanz

      Version of Record online: 24 DEC 2010 | DOI: 10.1038/emboj.2010.343

      The Endopeptidase-like and Kinase associated to transcribed Chromatin (KEOPS)/Endopeptidase-like and Kinase associated to transcribed Chromatin (EKC) complex has been implicated in multiple biological processes including transcription, telomere maintenance and chromosome segregation. This study reveals a role in the biosynthesis of a universal tRNA modification threonyl carbamoyl adenosine (t6A).

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      A role for the universal Kae1/Qri7/YgjD (COG0533) family in tRNA modification (pages 882–893)

      Basma El Yacoubi, Isabelle Hatin, Christopher Deutsch, Tamer Kahveci, Jean-Pierre Rousset, Dirk Iwata-Reuyl, Alexey G Murzin and Valérie de Crécy-Lagard

      Version of Record online: 1 FEB 2011 | DOI: 10.1038/emboj.2010.363

      The KEOPS/EKC complex has been implicated in diverse biological processes including transcription, telomere maintenance and chromosome segregation. This study reports that the Kae1 subunit plays an enzymatic role in the biosynthesis pathway of the universal tRNA modification threonyl carbamoyl adenosine (t6A).

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      Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response (pages 894–905)

      Maruf M U Ali, Tina Bagratuni, Emma L Davenport, Piotr R Nowak, M Cris Silva-Santisteban, Anthea Hardcastle, Craig McAndrews, Martin G Rowlands, Gareth J Morgan, Wynne Aherne, Ian Collins, Faith E Davies and Laurence H Pearl

      Version of Record online: 11 FEB 2011 | DOI: 10.1038/emboj.2011.18

      In the endoplasmic reticulum, unfolded proteins stimulate Ire1 autophosphorylation and RNase activity. The crystal structure of the dephosphorylated kinase/RNase domain of human Ire1 bound to ADP provides insight into the autophosphorylation reaction.

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      A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging (pages 906–919)

      Daniel G Booth, Fiona E Hood, Ian A Prior and Stephen J Royle

      Version of Record online: 4 FEB 2011 | DOI: 10.1038/emboj.2011.15

      A protein complex including the vesicle coat protein clathrin is here shown to constitute a population of inter-microtubule bridges in the mitotic spindle, which crosslink kinetochore fibres to stabilise them.

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      Modular assembly of yeast mitochondrial ATP synthase (pages 920–930)

      Malgorzata Rak, Samanta Gokova and Alexander Tzagoloff

      Version of Record online: 25 JAN 2011 | DOI: 10.1038/emboj.2010.364

      The assembly of the mitochondrial F1–FO ATP synthase complex involves two separate assembly intermediates, an Atp6p/Atp8p complex and the Atp9p ring in complex with the F1 sector.

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      Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase (pages 931–944)

      Usheer Kanjee, Irina Gutsche, Eftichia Alexopoulos, Boyu Zhao, Majida El Bakkouri, Guillaume Thibault, Kaiyin Liu, Shaliny Ramachandran, Jamie Snider, Emil F Pai and Walid A Houry

      Version of Record online: 28 JAN 2011 | DOI: 10.1038/emboj.2011.5

      The inducible lysine decarboxylase, LdcI, has a protective role during acid stress in bacteria. An inhibitory interaction between LdcI and the stringent response effector ppGpp is required for modulating LdcI activity during acid stress under starvation conditions.

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      Polyglutamine Atrophin provokes neurodegeneration in Drosophila by repressing fat (pages 945–958)

      Francesco Napoletano, Simona Occhi, Piera Calamita, Vera Volpi, Eric Blanc, Bernard Charroux, Julien Royet and Manolis Fanto

      Version of Record online: 28 JAN 2011 | DOI: 10.1038/emboj.2011.1

      Dentatorubral-pallidoluysian Atrophy is a neurodegenerative disease caused by the expansion of a CAG stretch in the atrophin-1 gene. The findings of this study report that Atrophin promotes neurodegeneration in Drosophila by repressing the expression of the tumour suppressor fat and reveal a neuroprotective role of the conserved Fat/Hippo pathway.

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      Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers (pages 959–971)

      Maxim Rossmann, Madhav Sukumaran, Andrew C Penn, Dmitry B Veprintsev, M Madan Babu and Ingo H Greger

      Version of Record online: 11 FEB 2011 | DOI: 10.1038/emboj.2011.16

      This study investigates the structural and mechanistic basis for AMPAR subunit assembly and reveals that the N-terminal domain regulates the formation of diverse pools of AMPAR tetramers.

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      Dynamics and allosteric potential of the AMPA receptor N-terminal domain (pages 972–982)

      Madhav Sukumaran, Maxim Rossmann, Indira Shrivastava, Anindita Dutta, Ivet Bahar and Ingo H Greger

      Version of Record online: 11 FEB 2011 | DOI: 10.1038/emboj.2011.17

      The crystal structure of the AMPA receptor subunit GluA3 N-terminal domain (NTD) reveals unexpected structural flexibility of the NTD that might affect ion channel activity.

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