Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response (pages 894–905)
Maruf M U Ali, Tina Bagratuni, Emma L Davenport, Piotr R Nowak, M Cris Silva-Santisteban, Anthea Hardcastle, Craig McAndrews, Martin G Rowlands, Gareth J Morgan, Wynne Aherne, Ian Collins, Faith E Davies and Laurence H Pearl
Version of Record online: 11 FEB 2011 | DOI: 10.1038/emboj.2011.18
In the endoplasmic reticulum, unfolded proteins stimulate Ire1 autophosphorylation and RNase activity. The crystal structure of the dephosphorylated kinase/RNase domain of human Ire1 bound to ADP provides insight into the autophosphorylation reaction.