The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis (pages 1357–1375)
Kezhong Zhang, Shiyu Wang, Jyoti Malhotra, Justin R Hassler, Sung Hoon Back, Guohui Wang, Lin Chang, Wenbo Xu, Hongzhi Miao, Roberta Leonardi, Y Eugene Chen, Suzanne Jackowski and Randal J Kaufman
Version of Record online: 15 MAR 2011 | DOI: 10.1038/emboj.2011.52
Ire1α is an important stress sensor in the unfolded protein response. The present study characterizes its essential function in liver lipid homeostasis based on hepatocyte-specific Ire1α knockout mice.