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The EMBO Journal

Cover image for Vol. 32 Issue 17

August 28, 2013

Volume 32, Issue 17

Pages 2301–2419

  1. Have you seen?

    1. Top of page
    2. Have you seen?
    3. Review
    4. Article
    5. Erratum
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      Histone deacetylases govern heterochromatin in every phase (pages 2301–2303)

      Yota Murakami

      Version of Record online: 5 JUL 2013 | DOI: 10.1038/emboj.2013.154

      Sir2-dependent histone deacetylation recruits the histone methyltransferase Clr4, spreading repressive H3K9-methylation during centromeric heterochromatin assembly.

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      Twisting chromatin in stem cells (pages 2304–2306)

      Paul Ginno and Dirk Schübeler

      Version of Record online: 6 AUG 2013 | DOI: 10.1038/emboj.2013.179

      Assessment of the higher-order genome structure in various types of pluripotent stem cells revealed a rather unique genomic landscape/pattern of chromatin organization, predominantly governed by the pluripotency transcription factor network.

  2. Review

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    3. Review
    4. Article
    5. Erratum
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      The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications (pages 2307–2320)

      Pascal Genschik, Izabela Sumara and Esther Lechner

      Version of Record online: 2 AUG 2013 | DOI: 10.1038/emboj.2013.173

      Pascal Genschik and colleagues review the fascinating array of signalling, cell cycle, and stress response roles that Cullin3/Rbx1/BTB-protein ubiquitin ligases play in both metazoan organisms and higher plants.

  3. Article

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    3. Review
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      Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly in fission yeast (pages 2321–2335)

      Benjamin J Alper, Godwin Job, Rajesh K Yadav, Sreenath Shanker, Brandon R Lowe and Janet F Partridge

      Version of Record online: 14 JUN 2013 | DOI: 10.1038/emboj.2013.143

      The demonstration that H3K14 deacetylation promotes recruitment of the Clr4 histone methyltransferase establishes a new function for the Sir2 deacetylase in de novo heterochromatin formation.

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      Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury (pages 2336–2347)

      Ikuko Maejima, Atsushi Takahashi, Hiroko Omori, Tomonori Kimura, Yoshitsugu Takabatake, Tatsuya Saitoh, Akitsugu Yamamoto, Maho Hamasaki, Takeshi Noda, Yoshitaka Isaka and Tamotsu Yoshimori

      Version of Record online: 6 AUG 2013 | DOI: 10.1038/emboj.2013.171

      Lysosomal damage can lead to oxidative stress, inflammation, and apoptosis or necrosis. Damaged lysosomes recruit the autophagic machinery leading to their sequestration. Loss of autophagy increases the kidney damage resulting from lysosomal damage.

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      Mfn2 modulates the UPR and mitochondrial function via repression of PERK (pages 2348–2361)

      Juan Pablo Muñoz, Saška Ivanova, Jana Sánchez-Wandelmer, Paula Martínez-Cristóbal, Eduard Noguera, Ana Sancho, Angels Díaz-Ramos, María Isabel Hernández-Alvarez, David Sebastián, Caroline Mauvezin, Manuel Palacín and Antonio Zorzano

      Version of Record online: 6 AUG 2013 | DOI: 10.1038/emboj.2013.168

      Mitochondrial–ER bridging protein mitofusin 2 (Mfn2) orchestrates mitochondrial metabolism and the UPR by suppressing PERK.

      Corrected by:

      Corrigendum: Mfn2 modulates the UPR and mitochondrial function via repression of PERK

      Vol. 33, Issue 2, 171, Version of Record online: 14 JAN 2014

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      The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit (pages 2362–2376)

      Anna Raffaello, Diego De Stefani, Davide Sabbadin, Enrico Teardo, Giulia Merli, Anne Picard, Vanessa Checchetto, Stefano Moro, Ildikò Szabò and Rosario Rizzuto

      Version of Record online: 30 JUL 2013 | DOI: 10.1038/emboj.2013.157

      The ubiquitous mitochondrial calcium uniporter (MCU) oligomerizes to form pores. MCU also oligomerizes with a new dominant-negative isoform, MCUb, which blocks calcium uptake revealing a new mechanism of mitochondrial calcium homeostasis and thus aerobic metabolism and apoptosis.

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      MicroRNA-17∼92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways (pages 2377–2391)

      Hyun Yong Jin, Hiroyo Oda, Maoyi Lai, Rebecca L Skalsky, Kelly Bethel, Jovan Shepherd, Seung Goo Kang, Wen-Hsien Liu, Mohsen Sabouri-Ghomi, Bryan R Cullen, Klaus Rajewsky and Changchun Xiao

      Version of Record online: 6 AUG 2013 | DOI: 10.1038/emboj.2013.178

      B cell-specific knockout of the miRNA 17∼92 cluster corroborates its oncogenic properties. Application of PAR-CLIP establishes unique and novel molecular targets of this first-ever described oncogenic miRNA

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      WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition (pages 2392–2406)

      Naoyuki Sarai, Keisuke Nimura, Tomohiko Tamura, Tomohiko Kanno, Mira C Patel, Tom D Heightman, Kiyoe Ura and Keiko Ozato

      Version of Record online: 6 AUG 2013 | DOI: 10.1038/emboj.2013.176

      The methyltransferase WHSC1 contributes to P-TEFb-dependent transcriptional elongation and drives prolonged incorporation of the histone variant H3.3 into inducible genes.

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      Mobilization of a plant transposon by expression of the transposon-encoded anti-silencing factor (pages 2407–2417)

      Yu Fu, Akira Kawabe, Mathilde Etcheverry, Tasuku Ito, Atsushi Toyoda, Asao Fujiyama, Vincent Colot, Yoshiaki Tarutani and Tetsuji Kakutani

      Version of Record online: 30 JUL 2013 | DOI: 10.1038/emboj.2013.169

      In Arabidopsis, the autonomously mobile element Hiun counteracts DNA methylation-induced silencing by expression of an anti-silencer protein—a mechanism that might have led to its broad distribution in plants.

  4. Erratum

    1. Top of page
    2. Have you seen?
    3. Review
    4. Article
    5. Erratum
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      Ral mediates activity-dependent growth of postsynaptic membranes via recruitment of the exocyst (pages 2418–2419)

      Rita O Teodoro, Gulçin Pekkurnaz, Abdullah Nasser, Misao E Higashi-Kovtun, Maria Balakireva, Ian G McLachlan, Jacques Camonis and Thomas L Schwarz

      Version of Record online: 28 AUG 2013 | DOI: 10.1038/emboj.2013.181

      This article corrects:

      Ral mediates activity-dependent growth of postsynaptic membranes via recruitment of the exocyst

      Vol. 32, Issue 14, 2039–2055, Version of Record online: 28 JUN 2013

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