Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury (pages 2336–2347)
Ikuko Maejima, Atsushi Takahashi, Hiroko Omori, Tomonori Kimura, Yoshitsugu Takabatake, Tatsuya Saitoh, Akitsugu Yamamoto, Maho Hamasaki, Takeshi Noda, Yoshitaka Isaka and Tamotsu Yoshimori
Version of Record online: 6 AUG 2013 | DOI: 10.1038/emboj.2013.171
Lysosomal damage can lead to oxidative stress, inflammation, and apoptosis or necrosis. Damaged lysosomes recruit the autophagic machinery leading to their sequestration. Loss of autophagy increases the kidney damage resulting from lysosomal damage.