These authors contributed equally to the review.
Ubiquitin in the immune system
Version of Record online: 27 DEC 2013
© 2014 The Authors.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Volume 15, Issue 1, pages 28–45, January 2014
How to Cite
Zinngrebe, J., Montinaro, A., Peltzer, N. and Walczak, H. (2014), Ubiquitin in the immune system. EMBO reports, 15: 28–45. doi: 10.1002/embr.201338025
See the Glossary for abbreviations used in this article.
- Issue online: 7 JAN 2014
- Version of Record online: 27 DEC 2013
- Manuscript Accepted: 13 NOV 2013
- Manuscript Revised: 11 NOV 2013
- Manuscript Received: 24 SEP 2013
- Boehringer Ingelheim Fonds
- Swiss National Science Foundation
Corrigendum: Ubiquitin in the immune system
Vol. 15, Issue 3, 322, Version of Record online: 7 MAR 2014
- E3 ligases;
Ubiquitination is a post-translational modification process that has been implicated in the regulation of innate and adaptive immune responses. There is increasing evidence that both ubiquitination and its reversal, deubiquitination, play crucial roles not only during the development of the immune system but also in the orchestration of an immune response by ensuring the proper functioning of the different cell types that constitute the immune system. Here, we provide an overview of the latest discoveries in this field and discuss how they impact our understanding of the ubiquitin system in host defence mechanisms as well as self-tolerance.