These authors share last author position.
PINK1 function in health and disease
Version of Record online: 12 JUN 2009
Copyright © 2009 EMBO Molecular Medicine
EMBO Molecular Medicine
Volume 1, Issue 3, pages 152–165, June 2009
How to Cite
Deas, E., Plun-Favreau, H. and Wood, N. W. (2009), PINK1 function in health and disease. EMBO Mol Med, 1: 152–165. doi: 10.1002/emmm.200900024
- Issue online: 12 JUN 2009
- Version of Record online: 12 JUN 2009
- Manuscript Accepted: 4 MAY 2009
- Manuscript Received: 20 APR 2009
- calcium signalling;
- oxidative stress;
The role of mitochondria in sporadic Parkinson's disease (PD) has been debated for a little over 20 years since the description of complex I deficiency in the substantia nigra pars compacta (SNpc) of PD patients. However, the identification of recessive pathogenic mutations in the pink1 gene in familial PD cases firmly re-ignited interest in the pathophysiology of mitochondria in PD. PINK1 is a putative mitochondrial serine/threonine kinase, which protects cells against oxidative stress induced apoptosis. The mechanism by which this is achieved and the effect of the pathogenic mutations has been an area of intensive research over the past five years. Significant progress has been made and, in this review, we summarize the physiological roles that have been assigned to PINK1 and the potential mechanisms behind pathogenesis.