Research Article

You have open access to this content

Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene

  1. Shyra J. Miller1,†,
  2. Walter J. Jessen2,†,
  3. Tapan Mehta4,
  4. Atira Hardiman1,
  5. Emily Sites1,
  6. Sergio Kaiser2,3,
  7. Anil G. Jegga2,
  8. Hua Li5,
  9. Meena Upadhyaya6,
  10. Marco Giovannini7,8,
  11. David Muir9,
  12. Margaret R. Wallace5,
  13. Eva Lopez10,
  14. Eduard Serra10,
  15. G. Petur Nielsen11,
  16. Conxi Lazaro10,
  17. Anat Stemmer-Rachamimov11,
  18. Grier Page4,
  19. Bruce J. Aronow2,
  20. Nancy Ratner1,*

Article first published online: 10 JUL 2009

DOI: 10.1002/emmm.200900027

Issue

EMBO Molecular Medicine

EMBO Molecular Medicine

Volume 1, Issue 4, pages 236–248, July 2009

Additional Information

How to Cite

Miller, S. J., Jessen, W. J., Mehta, T., Hardiman, A., Sites, E., Kaiser, S., Jegga, A. G., Li, H., Upadhyaya, M., Giovannini, M., Muir, D., Wallace, M. R., Lopez, E., Serra, E., Nielsen, G. P., Lazaro, C., Stemmer-Rachamimov, A., Page, G., Aronow, B. J. and Ratner, N. (2009), Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene. EMBO Mol Med, 1: 236–248. doi: 10.1002/emmm.200900027

Author Information

  1. 1

    Divisions of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH, USA

  2. 2

    Divisions of Biomedical Informatics, Cincinnati Children's Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH, USA

  3. 3

    Present address: Novartis Pharma AG, Basel, Switzerland

  4. 4

    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL, USA

  5. 5

    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL, USA

  6. 6

    Institute of Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff CF, UK

  7. 7

    INSERM U434, Foundation Jean Dausset-CEPH, Paris, France

  8. 8

    Present address: House Ear Institute, Department of Neural Tumor Research, Los Angeles, CA, USA

  9. 9

    Departments of Pediatrics and Neuroscience, University of Florida, Gainesville, FL, USA

  10. 10

    Centre de Genètica Mèdica i Molecular (EL and ES), Laboratori de Recerca Translacional, Institut Català d'Oncologia (CL); Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain

  11. 11

    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

  1. †

    Contributed equally to this work.

*Tel: +1 513 636 9469; Fax: +1 513 636 3549

Publication History

  1. Issue published online: 10 JUL 2009
  2. Article first published online: 10 JUL 2009
  3. Manuscript Accepted: 5 JUN 2009
  4. Manuscript Received: 18 DEC 2008

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (815K)

Cited in:

CrossRef
PubMed Central
Web of Science®(8)

This article has been cited by:

  1. 1
    Nicole M. Brossier, Steven L. Carroll, Genetically engineered mouse models shed new light on the pathogenesis of neurofibromatosis type I-related neoplasms of the peripheral nervous system, Brain Research Bulletin, 2012, 88, 1, 58

    CrossRef

  2. 2
    Meena Upadhyaya, Gill Spurlock, Laura Thomas, Nick S. T. Thomas, Mark Richards, Viktor-Felix Mautner, David N. Cooper, Abhijit Guha, Jim Yan, Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho–GTPase pathway genes in NF1 tumorigenesis, Human Mutation, 2012, 33, 4
    Direct Link:
  3. 3
    Fausto J. Rodriguez, Andrew L. Folpe, Caterina Giannini, Arie Perry, Pathology of peripheral nerve sheath tumors: diagnostic overview and update on selected diagnostic problems, Acta Neuropathologica, 2012, 123, 3, 295

    CrossRef

  4. 4
    Mateusz Kolanczyk, Victor Mautner, Nadine Kossler, Rosa Nguyen, Jirko Kühnisch, Tomasz Zemojtel, Aleksander Jamsheer, Eike Wegener, Boris Thurisch, Sigrid Tinschert, Nikola Holtkamp, Su-Jin Park, Patricia Birch, David Kendler, Anja Harder, Stefan Mundlos, Lan Kluwe, MIA is a potential biomarker for tumour load in neurofibromatosis type 1, BMC Medicine, 2011, 9, 1, 82

    CrossRef

  5. 5
    Steven L. Carroll, Molecular mechanisms promoting the pathogenesis of Schwann cell neoplasms, Acta Neuropathologica, 2011, 123, 3, 321

    CrossRef

  6. 6
    F. Chibon, J.-M. Coindre, Sarkome: Gensignaturen, Der Pathologe, 2011, 32, 1, 32

    CrossRef

  7. 7
    James Pritchett, Varinder Athwal, Neil Roberts, Neil A Hanley, Karen Piper Hanley, Understanding the role of SOX9 in acquired diseases: lessons from development, Trends in Molecular Medicine, 2011, 17, 3, 166

    CrossRef

  8. 8
    Robert B. West, Expression Profiling in Soft Tissue Sarcomas With Emphasis on Synovial Sarcoma, Gastrointestinal Stromal Tumor, and Leiomyosarcoma, Advances in Anatomic Pathology, 2010, 17, 5, 366

    CrossRef

  9. 9
    Gill Spurlock, Samantha J. L. Knight, Nick Thomas, Tim-Rasmus Kiehl, Abhijit Guha, Meena Upadhyaya, Molecular evolution of a neurofibroma to malignant peripheral nerve sheath tumor (MPNST) in an NF1 patient: correlation between histopathological, clinical and molecular findings, Journal of Cancer Research and Clinical Oncology, 2010, 136, 12, 1869

    CrossRef

  10. 10
    Karl Staser, Feng-Chun Yang, David W Clapp, Plexiform neurofibroma genesis: questions of Nf1 gene dose and hyperactive mast cells, Current Opinion in Hematology, 2010, 17, 4, 287

    CrossRef

  11. 11
    Joseph L. Kissil, Jaishri O. Blakeley, Rosalie E. Ferner, Susan M. Huson, Michel Kalamarides, Victor-Felix Mautner, Frank McCormick, Helen Morrison, Roger Packer, Vijaya Ramesh, Nancy Ratner, Katherine A. Rauen, David A. Stevenson, Kim Hunter-Schaedle, Kathryn North, What's new in neurofibromatosis? Proceedings from the 2009 NF Conference: New Frontiers, American Journal of Medical Genetics Part A, 2010, 152A, 2
    Direct Link:
  12. 12
    S J Miller, Z D Lan, A Hardiman, J Wu, J J Kordich, D M Patmore, R S Hegde, T P Cripe, J A Cancelas, M H Collins, N Ratner, Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis, Oncogene, 2009, 29, 3, 368

    CrossRef

  13. You have open access to this content13
    Karlyne M. Reilly, Neurofibromatosis and lessons for the war on cancer, EMBO Molecular Medicine, 2009, 1, 4
    Direct Link:
View Full Article with Supporting Information (HTML) Get PDF (815K)