• Open Access

Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins

Authors

  • Taro Kawai,

    Corresponding author
    1. Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
    2. Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    • Tel: +81 6 6879 8303, Fax: +81 6 6879 8305

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  • Shizuo Akira

    1. Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
    2. Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
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Abstract

The innate immune system recognizes microbial components through pattern-recognition receptors (PRRs), including membrane-bound Toll-like receptors and cytosolic receptors such as RIG-I-like receptors and deoxyribonucleic acid (DNA) sensors. These PRRs trigger distinct signal transduction pathways that culminate in induction of an array of cytokines and other mediators required for host defense. The tripartite motif (TRIM) family is a diverse family of RING finger domain-containing proteins, which are involved in a variety of cellular functions. Importantly, recent studies have shown that they are also involved in the regulation of innate immune responses through the modulation of PRR signalling pathways.

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