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β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment

  1. Jun Cai1,†,
  2. Xiaoping Qi1,†,
  3. Norbert Kociok2,
  4. Sergej Skosyrski2,
  5. Alonso Emilio1,
  6. Qing Ruan1,
  7. Song Han3,
  8. Li Liu4,
  9. Zhijuan Chen1,
  10. Catherine Bowes Rickman5,
  11. Todd Golde6,
  12. Maria B. Grant4,
  13. Paul Saftig7,
  14. Lutgarde Serneels8,9,
  15. Bart de Strooper8,9,
  16. Antonia M. Joussen2,
  17. Michael E. Boulton1,*

Article first published online: 20 AUG 2012

DOI: 10.1002/emmm.201101084

Issue

EMBO Molecular Medicine

EMBO Molecular Medicine

Volume 4, Issue 9, pages 980–991, September 2012

Additional Information

How to Cite

Cai, J., Qi, X., Kociok, N., Skosyrski, S., Emilio, A., Ruan, Q., Han, S., Liu, L., Chen, Z., Bowes Rickman, C., Golde, T., Grant, M. B., Saftig, P., Serneels, L., de Strooper, B., Joussen, A. M. and Boulton, M. E. (2012), β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment. EMBO Mol Med, 4: 980–991. doi: 10.1002/emmm.201101084

Author Information

  1. 1

    Department of Anatomy & Cell Biology, University of Florida, Gainesville, FL, USA

  2. 2

    Department of Ophthalmology, Charité Universitätsmedizin Berlin, Berlin, Germany

  3. 3

    Department of Surgery, University of Florida, Gainesville, FL, USA

  4. 4

    Department of Pharmacology & Therapeutics, University of Florida, Gainesville, FL, USA

  5. 5

    Department of Ophthalmology & of Cell Biology, Duke University Medical Center, Durham, NC, USA

  6. 6

    Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA

  7. 7

    Biochemical Institute, Christian-Albrecht's University, Kiel, Germany

  8. 8

    Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases (LIND), KU Leuven, Leuven, Belgium

  9. 9

    VIB Center for the Biology of Disease, Vlaams Instituut voor Biotechnologie, Leuven, Belgium

  1. †

    These authors contributed equally to this work.

*Tel: +1 3522738546; Fax: +1 3523923305

  • †

    These authors contributed equally to this work.

Publication History

  1. Issue published online: 4 SEP 2012
  2. Article first published online: 20 AUG 2012
  3. Manuscript Accepted: 28 JUN 2012
  4. Manuscript Revised: 23 JUN 2012
  5. Manuscript Received: 17 NOV 2011

Funded by

  • NIH. Grant Number: EY018358
  • NIH. Grant Number: EY019688
  • AHAF. Grant Number: M2009024
  • Funded Access

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