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Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease

  1. Francesc X. Guix1,2,
  2. Tina Wahle1,2,
  3. Kristel Vennekens1,2,
  4. An Snellinx1,2,
  5. Lucía Chávez-Gutiérrez1,2,
  6. Gerard Ill-Raga3,
  7. Eva Ramos-Fernandez3,
  8. Cristina Guardia-Laguarta4,
  9. Alberto Lleó4,
  10. Muriel Arimon5,
  11. Oksana Berezovska5,
  12. Francisco J. Muñoz3,
  13. Carlos G. Dotti1,2,6,*,
  14. Bart De Strooper1,2,*

Article first published online: 2 MAY 2012

DOI: 10.1002/emmm.201200243

Issue

EMBO Molecular Medicine

EMBO Molecular Medicine

Volume 4, Issue 7, pages 660–673, July 2012

Additional Information

How to Cite

Guix, F. X., Wahle, T., Vennekens, K., Snellinx, A., Chávez-Gutiérrez, L., Ill-Raga, G., Ramos-Fernandez, E., Guardia-Laguarta, C., Lleó, A., Arimon, M., Berezovska, O., Muñoz, F. J., Dotti, C. G. and De Strooper, B. (2012), Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease. EMBO Mol Med, 4: 660–673. doi: 10.1002/emmm.201200243

Author Information

  1. 1

    VIB Center for Biology of Disease – VIB, Leuven, Belgium

  2. 2

    Center of Human Genetics and Leuven Institute for Neurodegenerative Diseases (LIND), KULeuven, Leuven, Gasthuisberg O&N, Belgium

  3. 3

    Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain

  4. 4

    Alzheimer Laboratory, Neurology Department, Hospital de la Santa Creu i Sant Pau, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain

  5. 5

    Alzheimer Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Charlestown, MA, USA

  6. 6

    Centro de Biología Molecular Severo Ochoa (CSIC/UAM), Madrid, Spain

*Tel: +32 16 330519; Fax: +32 16 330522

Publication History

  1. Issue published online: 3 JUL 2012
  2. Article first published online: 2 MAY 2012
  3. Accepted manuscript online: 10 APR 2012 05:10AM EST
  4. Manuscript Revised: 30 MAR 2012
  5. Manuscript Accepted: 30 MAR 2012
  6. Manuscript Received: 6 DEC 2011

Funded by

  • NIH. Grant Number: AG15379

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