New approaches to the study of sepsis
Version of Record online: 4 DEC 2012
Copyright © 2012 The Authors. Published by John Wiley and Sons, Ltd on behalf of EMBO. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
EMBO Molecular Medicine
Volume 4, Issue 12, pages 1234–1243, December 2012
How to Cite
Ward, P. A. (2012), New approaches to the study of sepsis. EMBO Mol Med, 4: 1234–1243. doi: 10.1002/emmm.201201375
- Issue online: 4 DEC 2012
- Version of Record online: 4 DEC 2012
- Manuscript Accepted: 5 OCT 2012
- Manuscript Revised: 13 SEP 2012
- Manuscript Received: 13 AUG 2012
- Funded Access
- clinical trials;
Models of sepsis have been instructive in understanding the sequence of events in animals and, to an extent, in humans with sepsis. Events developing early in sepsis suggest that a hyperinflammatory state exists, accompanied by a buildup of oxidants in tissues reflective of a redox imbalance. Development of immunosuppression and degraded innate and adaptive immune responses are well-established complications of sepsis. In addition, there is robust activation of the complement system, which contributes to the harmful effects of sepsis. These events appear to be associated with development of multiorgan failure. The relevance of animal models of sepsis to human sepsis and the failure of human clinical trials are discussed, together with suggestions as to how clinical trial design might be improved.