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Dendrimers branch out to support mucosal integrity

Dermot Kelleher^1,2,*

Article first published online: 22 AUG 2012

DOI: 10.1002/emmm.201201668

Copyright © 2012 EMBO Molecular Medicine

Issue

EMBO Molecular Medicine

EMBO Molecular Medicine

Volume 4, Issue 9, pages 860–862, September 2012

Additional Information

How to Cite

Kelleher, D. (2012), Dendrimers branch out to support mucosal integrity. EMBO Mol Med, 4: 860–862. doi: 10.1002/emmm.201201668

Author Information

¹
Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
²
Present address: Faculty of Medicine, Imperial College London, London, UK

Email: Dermot Kelleher (d.kelleher@imperial.ac.uk)

^*Tel: +44 2075941190; Fax: +44 2075949843

Publication History

Issue published online: 4 SEP 2012
Article first published online: 22 AUG 2012

ARTICLE TOOLS

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References

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Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R (2004) Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118: 229- 241
Ryan A, Lynch M, Smith SM, Amu S, Nel HJ, McCoy CE, Dowling JK, Draper E, O'Reilly V, McCarthy C, et al (2011) A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins. PLoS Pathog 7: e1002076
Song J, Duncan MJ, Li G, Chan C, Grady R, Stapleton A, Abraham SN (2007) A novel TLR4-mediated signaling pathway leading to IL-6 responses in human bladder epithelial cells. PLoS Pathog 3: e60
Suzuki T, Yoshinaga N, Tanabe S (2011) Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium. J Biol Chem 286: 31263- 31271
Teo I, Toms S, Benoit M, Barata T, Simpson P, Johnston K, Schnupf P, Puhar A, Bell T, Tang C, et al (2012) Preventing acute gut wall damage in infectious diarrhoeas with glycosylated dendrimers. EMBO Mol Med DOI: 10.1002/emmm.201201290
Direct Link:
Yang R, Han X, Uchiyama T, Watkins SK, Yaguchi A, Delude RL, Fink MP (2003) IL-6 is essential for development of gut barrier dysfunction after hemorrhagic shock and resuscitation in mice. Am J Physiol Gastrointest Liver Physiol 285: G621- G629
Yamamoto M, Yoshizaki K, Kishimoto T, Ito H (2000) IL-6 is required for the development of Th1 cell-mediated murine colitis. J Immunol 164: 4878- 4882
Walter MV, Malkoch M (2012) Simplifying the synthesis of dendrimers: accelerated approaches. Chem Soc Rev 41: 4593- 4609

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