Alteration of the microRNA network during the progression of Alzheimer's disease
Version of Record online: 9 SEP 2013
Copyright © 2013 The Authors. Published by John Wiley and Sons, Ltd on behalf of EMBO
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
EMBO Molecular Medicine
Volume 5, Issue 10, pages 1613–1634, October 2013
How to Cite
Lau, P., Bossers, K., Janky, R., Salta, E., Frigerio, C. S., Barbash, S., Rothman, R., Sierksma, A. S. R., Thathiah, A., Greenberg, D., Papadopoulou, A. S., Achsel, T., Ayoubi, T., Soreq, H., Verhaagen, J., Swaab, D. F., Aerts, S. and De Strooper, B. (2013), Alteration of the microRNA network during the progression of Alzheimer's disease. EMBO Mol Med, 5: 1613–1634. doi: 10.1002/emmm.201201974
- Issue online: 2 OCT 2013
- Version of Record online: 9 SEP 2013
- Manuscript Accepted: 26 JUL 2013
- Manuscript Revised: 25 JUL 2013
- Manuscript Received: 3 SEP 2012
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Figure S1. Quality assessment of the total RNA and distribution of the nCounter raw data
Figure S2. Comparison of the raw data from hippocampus samples showing different RIN values.
Figure S3. Skewness and overdispersion of the nCounter data.
Figure S4. Multiple-group comparison of the prefrontal cortex data obtained with the nCounter system.
Figure S5. Comparison of deregulated miRNAs in diverse brain areas of LOAD patients.
Figure S6. Co-targets of miR-132-3p and the FOX transcription factors.
Table S1. Clinical diagnosis of cohort 1 (hippocampus samples).
Table S2. Clinical data of sample cases in the cohort 2 (prefrontal cortex samples)
Table S3. Clinical diagnosis of sample cases in the cohort 3 (temporal gyrus samples).
Table S4. MiRNAs called different by deep-sequencing and without corresponding probes in the nCounter system.
Table S5. Percentage of neurons positive for miR-132-3p in the prefrontal cortex.
Table S6. miR-132-3p predictions for Tau related targets and FOX targets by different algorithms.
Table S7. Enrichment of transcription factor binding sites in the promoter of genes downregulated between BRI and BRVI.
Table S8. Detection of FOX motifs by HOMER (known motif approach) in the different gene sets.
Table S9. List of PCR primers used for 3'UTR cloning.
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