MicroRNAs in age-related diseases
Article first published online: 22 JAN 2013
Copyright © 2013 EMBO Molecular Medicine
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
EMBO Molecular Medicine
Volume 5, Issue 2, pages 180–190, February 2013
How to Cite
Dimmeler, S. and Nicotera, P. (2013), MicroRNAs in age-related diseases. EMBO Mol Med, 5: 180–190. doi: 10.1002/emmm.201201986
- Issue published online: 4 FEB 2013
- Article first published online: 22 JAN 2013
- Manuscript Accepted: 13 DEC 2012
- Manuscript Revised: 3 DEC 2012
- Manuscript Received: 5 SEP 2012
Aging is a complex process that is linked to an increased incidence of major diseases such as cardiovascular and neurodegenerative disease, but also cancer and immune disorders. MicroRNAs (miRNAs) are small non-coding RNAs, which post-transcriptionally control gene expression by inhibiting translation or inducing degradation of targeted mRNAs. MiRNAs target up to hundreds of mRNAs, thereby modulating gene expression patterns. Many miRNAs appear to be dysregulated during cellular senescence, aging and disease. However, only few miRNAs have been so far linked to age-related changes in cellular and organ functions. The present article will discuss these findings, specifically focusing on the cardiovascular and neurological systems.
This review is part of the small RNAs review series. See more reviews from this series. http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1757-4684/homepage/reviews_smallrnas.htm