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Figure S1 Proteomic analysis of a DLBCL nuclear acid soluble (NAS) fraction and identification of nuclear factors which show evidence of abnormal de-repression in lymphoma.

Figure S2. Association of H2AFY and CYCLON levels with clinical outcome in DLBCL.

Figure S3. Establishment of CYCLON knock-down lymphoma cell lines.

Figure S4. Differential expression of genes in CYCLON knock-down Raji lymphoma B cells.

Figure S5. Evaluation of drug sensitivity in CYCLON knock-down B lymphoma cells.

Figure S6. Characterization of JQ1 final compound.

Figure S7. Cell death assays upon JQ1 and JQ1/etoposide treatment.

Table S1. Protein list from LC-MS/MS analysis of B593 NAS fraction.

Table S2. Genes significantly modulated between Raji shCtrl and Raji shCYCLON cell lines.

Table S3. GSEA ‘Aggressive multiple myeloma’ signature.

Table S4. GSEA ‘CD40 dependent B cell’ signature.

Table S5. Oligonucleotides used for this study.

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