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Figure S1. Quantitative real-time PCR analysis for AML patients' bone marrow samples: high PRL-3 mRNA expression was associated with AML patients with FLT3-ITD mutation.

Figure S2. STAT5A and STAT5B protein expression levels with different reporter vectors.

Figure S3. AP-SEAP activity assay in DLD-1 and HCT116 cells: PRL-3 overexpression activates AP-1 activity.

Figure S4. Annexin-V and 7-AAD staining with MOLM-14 and MV4-11 cells: Depletion of PRL-3 shows no substantial increment in apoptotic population in two cytokine independent cell lines, MOLM-14 and MV4-11.

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