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Figure S1. A. Validation of Ret antibody for immunohistochemical (IHC) staining of paraffin sections.

Figure S2. A. Western bot (WB) analysis on lysates from MCF7/Aro, MCF7 and T47D cells was carried out with a Ret antibody (anti-human Ret antibody from Cell Signalling) in the upper panels.

Figure S3. A. Microarray slides were co-hybridized with cDNA from 6-day treated MCF7/Aro cells cultured in the 6 indicated conditions (as in Fig 2F).

Figure S4. A. MCF7 cells were pre-incubated with DMSO or NVP-AST487 (100 nM), then treated 15 min with IL6 (100 ng/ml) or GDNF (10 ng/ml).

Figure S5. A. Groups of J110-tumour bearing mice were randomized and treated once daily with vehicle (10%EtOH in corn oil) or tamoxifen (100 µg/day) for 3 weeks.

Figure S6. A, B. Tumours from mice treated as described in Fig 5C were harvested 8 hours after the final treatment.

Table S1. Correlation of Ret-score with established clinical and histopathological parameters of breast cancer patients.

Table S2. Correlation of Ret score with molecular subtypes of the analysed breast cancer patients.

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