These authors contributed equally to this work.
An essential role for decorin in bladder cancer invasiveness
Article first published online: 20 OCT 2013
© 2013 The Authors. Published by John Wiley and Sons, Ltd on behalf of EMBO
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
EMBO Molecular Medicine
Volume 5, Issue 12, pages 1835–1851, December 2013
How to Cite
El Behi, M., Krumeich, S., Lodillinsky, C., Kamoun, A., Tibaldi, L., Sugano, G., De Reynies, A., Chapeaublanc, E., Laplanche, A., Lebret, T., Allory, Y., Radvanyi, F., Lantz, O., Eiján, A. M., Bernard-Pierrot, I. and Théry, C. (2013), An essential role for decorin in bladder cancer invasiveness. EMBO Mol Med, 5: 1835–1851. doi: 10.1002/emmm.201302655
- Issue published online: 2 DEC 2013
- Article first published online: 20 OCT 2013
- Manuscript Accepted: 6 SEP 2013
- Manuscript Revised: 2 SEP 2013
- Manuscript Received: 19 FEB 2013
- INSERM, Institut Curie and by grants from Fondation de France (to CT), INCa (INCA_5975 to CT, OL and FR), La Ligue Nationale Contre le Cancer (FR: équipe labellisée; OL: équipe labellisée), and the program “Carte d'Identité des Tumeurs”, initiated, developed
- Ligue Nationale Contre le Cancer
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Figure S1. Analysis of immune cells infiltrating bladder five days after tumour injection.
Figure S2. Necrotic MB49-I cells do not activate HY-specific T cells.
Figure S3. MB49 grows faster than MB49-I in vitro.
Figure S4. Decorin knockdown in MB49-I cells does not affect the nature of immune cells infiltrating the tumour.
Figure S5. Two additional independent analyses confirm that decorin is overexpressed in human MIBC as compared to NMIBC.
Figure S6. DCN mRNA level is not correlated to DCN DNA level in bladder tumours.
Figure S7. Gene ontology annotation enriched within genes correlated to DCN.
Figure S8. Decorin is not required for in vitro proliferation of TCCSUP, and promotes matrigel invasion by MB49 and MB49-I cells in vitro.
Figure S9. A specific DCN isoform is expressed by muscle cells in bladder.
Table S1. Genes with mRNA expression level correlated or anticorrelated to DCN expression level in human MIBC.
Table S2. Functional pathways and gene ontology annotations relative to biological processes significantly enriched in genes positively correlated with DCN in human MIBC.
Table S3. Affymetrix U133plus2.0 microarray data in 162 human bladder tumours and 4 normal samples, for genes correlated with DCN in MIBC (Pearson R > 0.5).
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