These authors contributed equally to this work.
CCR2+ monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice
Version of Record online: 21 OCT 2013
Copyright © 2013 The Authors. Published by John Wiley and Sons, Ltd on behalf of EMBO
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
EMBO Molecular Medicine
Volume 5, Issue 11, pages 1775–1793, November 2013
How to Cite
Sennlaub, F., Auvynet, C., Calippe, B., Lavalette, S., Poupel, L., Hu, S. J., Dominguez, E., Camelo, S., Levy, O., Guyon, E., Saederup, N., Charo, I. F., Rooijen, N. V., Nandrot, E., Bourges, J.-L., Behar-Cohen, F., Sahel, J.-A., Guillonneau, X., Raoul, W. and Combadiere, C. (2013), CCR2+ monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice. EMBO Mol Med, 5: 1775–1793. doi: 10.1002/emmm.201302692
- Issue online: 4 NOV 2013
- Version of Record online: 21 OCT 2013
- Manuscript Accepted: 30 AUG 2013
- Manuscript Revised: 28 AUG 2013
- Manuscript Received: 28 FEB 2013
- INSERM, ANR blanc (AO5120DD), ANR Maladies Neurologiques et Psychiatriques (ANR-08-MNPS-003), ANR Geno 2009 (R09099DS), ANR Programme Emergence 2012 (ANR-EMMA-050), and ERC. Grant Number: (ERC-2007 St.G. 210345)
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Table S1. Demographic data of the study group of patients with geographic atrophy and the control group of patients without retinal disorders and undergoing routine cataract surgery.
Figure S1. CCR2 immunohistochemistry on healthy human blood smear.
Figure S2. Negative control and examples of CCR2+ immunohistochemistry on sections with geographic atrophy and age related maculopathy.
Figure S3. Intravitreal EdU injections in light-challenged Cx3cr1−/−mice.
Figure S4. Comparaison of subretinal MP accumulation in C57BL/6, Ccl2−/− and Cx3cr1−/− mice at 18 months under the same animal housing conditions.
Figure S5. Photoreceptor status in 3-month-old C57BL/6 and Cx3cr1−/− mice.
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