This review is part of the review series on cancer.
Hacking cell differentiation: transcriptional rerouting in reprogramming, lineage infidelity and metaplasia
Version of Record online: 4 JUL 2013
Copyright © 2013 The Authors. Published by John Wiley and Sons, Ltd on behalf of EMBO
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
EMBO Molecular Medicine
Volume 5, Issue 8, pages 1154–1164, August 2013
How to Cite
Regalo, G. and Leutz, A. (2013), Hacking cell differentiation: transcriptional rerouting in reprogramming, lineage infidelity and metaplasia. EMBO Mol Med, 5: 1154–1164. doi: 10.1002/emmm.201302834
- Issue online: 5 AUG 2013
- Version of Record online: 4 JUL 2013
- Manuscript Accepted: 4 JUN 2013
- Manuscript Revised: 29 MAY 2013
- Manuscript Received: 2 APR 2013
- transcription factor;
Initiating neoplastic cell transformation events are of paramount importance for the comprehension of regeneration and vanguard oncogenic processes but are difficult to characterize and frequently clinically overlooked. In epithelia, pre-neoplastic transformation stages are often distinguished by the appearance of phenotypic features of another differentiated tissue, termed metaplasia. In haemato/lymphopoietic malignancies, cell lineage ambiguity is increasingly recorded. Both, metaplasia and biphenotypic leukaemia/lymphoma represent examples of dysregulated cell differentiation that reflect a history of trans-differentiation and/or epigenetic reprogramming. Here we compare the similarity between molecular events of experimental cell trans-differentiation as an emerging therapeutic concept, with lineage confusion, as in metaplasia and dysplasia forecasting tumour development.