These authors contributed equally to this work.
A major role for RCAN1 in atherosclerosis progression
Article first published online: 15 OCT 2013
© 2013 The Authors. Published by John Wiley and Sons, Ltd on behalf of EMBO
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
EMBO Molecular Medicine
Volume 5, Issue 12, pages 1901–1917, December 2013
How to Cite
Méndez-Barbero, N., Esteban, V., Villahoz, S., Escolano, A., Urso, K., Alfranca, A., Rodríguez, C., Sánchez, S. A., Osawa, T., Andrés, V., Martínez-González, J., Minami, T., Redondo, J. M. and Campanero, M. R. (2013), A major role for RCAN1 in atherosclerosis progression. EMBO Mol Med, 5: 1901–1917. doi: 10.1002/emmm.201302842
- Issue published online: 2 DEC 2013
- Article first published online: 15 OCT 2013
- Manuscript Accepted: 3 SEP 2013
- Manuscript Revised: 8 AUG 2013
- Manuscript Received: 4 APR 2013
- The Spanish Ministry of Economy and Competitiveness (Ministerio de Economía y Competitividad) supports MRC, JMR and JM-G. Grant Numbers: SAF2010-15126, SAF2009-10708, SAF2012-40127
- Spanish Council for Scientific Research (CSIC); JMR is also supported by Fundación La Marató TV3 (080731), and Fundación Genoma España (GENOMA)
- The Red de Investigacion Cardiovascular (RIC) of the Spanish Ministry of Health (Ministerio de Sanidad) supports the research of JMR, VA and JM-G. Grant Numbers: RD12/0042/0022, RD12/0042/0028, RD12/0042/0053
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Figure S1. RCAN1 is induced in human atherosclerotic arteries.
Figure S2. Rcan1 gene targeting ablates expression of Rcan1-1 and Rcan1-4.
Figure S3. HFD-induced body weight increase and lipid profile changes are not mediated by Rcan1.
Figure S4. Rcan1 gene targeting increases fibrous cap thickness.
Figure S5. Rcan1 gene targeting does not increase MMP2 or MMP9 expression.
Figure S6. Rcan1 gene targeting does not induce intraplaque haemorrhage.
Figure S7. SR-A expression is not affected by Rcan1 gene targeting.
Figure S8. Rcan1 is a modest regulator of cholesterol efflux in macrophages.
Figure S9. Rcan1 does not mediate macrophage chemotaxis.
Figure S10. Macrophage motility is inhibited by oxLDL in an Rcan1-dependent manner.
Figure S11. Rcan1 gene targeting increases IL10 gene expression in the aortic arch of atherosclerotic mice.
Figure S12. Rcan1 regulates Arg1 expression, antigen presentation and phagocytic activity in macrophages.
Figure S13. Rcan1 does not regulate iNos expression in atherosclerotic lesions.
Figure S14. Rcan1 does not alter the nature of BM reconstitution.
Figure S15. Metabolic parameters in transplanted mice.
Figure S16. Rcan1 gene targeting does not alter CN activity in macrophages.
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