See also: HT Horing-Do et al (February 2014)
Mixing and matching mitochondrial aminoacyl synthetases and their tRNAs: a new way to treat respiratory chain disorders?
Version of Record online: 29 JAN 2014
© 2014 The Authors.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
EMBO Molecular Medicine
Volume 6, Issue 2, pages 155–157, February 2014
How to Cite
Tyynismaa, H. and Schon, E. A. (2014), Mixing and matching mitochondrial aminoacyl synthetases and their tRNAs: a new way to treat respiratory chain disorders?. EMBO Mol Med, 6: 155–157. doi: 10.1002/emmm.201303586
and E Perli et al (February 2014)
- Issue online: 7 FEB 2014
- Version of Record online: 29 JAN 2014
- Academy of Finland
- University of Helsinki
- Sigrid Juselius Foundation
- U.S. National Institutes of Health. Grant Number: HD32062
- Department of Defense. Grant Number: W911NF-12-1-0159
- Muscular Dystrophy Association
- Ellison Medical Foundation
- J. Willard and Alice S. Marriott Foundation
Mutations in mitochondrial DNA are an important cause of human disease and from a therapeutic standpoint, these disorders are currently untreatable. New studies now show that a non-cognate mitochondrial aminoacyl tRNA synthetase can overcome the respiratory defect caused by an mt-tRNA mutation and that the isolated carboxy-terminal domain of human mt-leucyl tRNA synthetase can ameliorate the pathologic phenotype.