The emerging role of Nrf2 in dermatotoxicology


  • Nguan S Tan,

    1. School of Biological Sciences, Nanyang Technological University, Singapore City, Singapore
    2. Institute of Molecular and Cell Biology, A*STAR, Singapore City, Singapore
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  • Walter Wahli

    Corresponding author
    1. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore General Hospital, Singapore City, Singapore
    2. Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
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The nuclear factor erythroid 2-related factor 2 (Nrf2) is best known for its role in resistance to oxidant stress. In this issue of EMBO Molecular Medicine, Nrf2-prolonged genetic activation is shown with devastating effects on skin homeostasis. The study provides novel molecular insights into poison-induced chloracne and metabolizing acquired dioxin-induced skin hamartomas or MADISH.