See also: JA Magida & LA Leinwand (April 2014)
The heart-liver metabolic axis: defective communication exacerbates disease
Article first published online: 12 MAR 2014
© 2014 The Authors. Published under the terms of the CC BY license.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
EMBO Molecular Medicine
Volume 6, Issue 4, pages 436–438, April 2014
How to Cite
Baskin, K. K., Bookout, A. L. and Olson, E. N. (2014), The heart-liver metabolic axis: defective communication exacerbates disease. EMBO Mol Med, 6: 436–438. doi: 10.1002/emmm.201303800
- Issue published online: 2 APR 2014
- Article first published online: 12 MAR 2014
The heart has been recognized as an endocrine organ for over 30 years (de Bold, 2011); however, little is known about how the heart communicates with other organs in the body, and even less is known about this process in the diseased heart. In this issue of EMBO Molecular Medicine, Magida and Leinwand (2014) introduce the concept that a primary genetic defect in the heart results in aberrant hepatic lipid metabolism, which consequently exacerbates hypertrophic cardiomyopathy (HCM). This study provides evidence in support of the hypothesis that crosstalk occurs between the heart and liver, and that this becomes disrupted in the diseased state.