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EMBO Molecular Medicine

Cover image for Vol. 4 Issue 12

December 2012

Volume 4, Issue 12

Pages i–ii, 1231–1319

  1. Masthead

    1. Top of page
    2. Masthead
    3. Closeup
    4. Review
    5. Research Articles
    1. You have full text access to this OnlineOpen article
      Masthead (pages i–ii)

      Article first published online: 4 DEC 2012 | DOI: 10.1002/emmm.201290012

  2. Closeup

    1. Top of page
    2. Masthead
    3. Closeup
    4. Review
    5. Research Articles
    1. You have full text access to this OnlineOpen article
  3. Review

    1. Top of page
    2. Masthead
    3. Closeup
    4. Review
    5. Research Articles
    1. You have full text access to this OnlineOpen article
      New approaches to the study of sepsis (pages 1234–1243)

      Peter A. Ward

      Article first published online: 4 DEC 2012 | DOI: 10.1002/emmm.201201375

      Thumbnail image of graphical abstract

      Currently there is no FDA-approved drug for use in sepsis. This Review discusses the relevance of animal models to human sepsis and the failure of human clinical trials and provides suggestions as to how clinical trial design might be improved.

  4. Research Articles

    1. Top of page
    2. Masthead
    3. Closeup
    4. Review
    5. Research Articles
    1. You have full text access to this OnlineOpen article
      Defining critical roles for NF-κB p65 and type I interferon in innate immunity to rhinovirus (pages 1244–1260)

      Nathan W. Bartlett, Louise Slater, Nicholas Glanville, Jennifer J. Haas, Gaetano Caramori, Paolo Casolari, Deborah L. Clarke, Simon D. Message, Julia Aniscenko, Tatiana Kebadze, Jie Zhu, Patrick Mallia, Joseph P. Mizgerd, Maria Belvisi, Alberto Papi, Sergei V. Kotenko, Sebastian L. Johnston and Michael R. Edwards

      Article first published online: 14 NOV 2012 | DOI: 10.1002/emmm.201201650

      Thumbnail image of graphical abstract

      The authors show that targeting NF-κB p65 may be a reasonable therapeutic strategy for asthma exacerbations, specifically addressing inflammation without compromising beneficial anti-viral immunity.

    2. You have full text access to this OnlineOpen article
      Carabin deficiency in B cells increases BCR-TLR9 costimulation-induced autoimmunity (pages 1261–1275)

      Jean-Nicolas Schickel, Jean-Louis Pasquali, Anne Soley, Anne-Marie Knapp, Marion Decossas, Aurélie Kern, Jean-Daniel Fauny, Luc Marcellin, Anne-Sophie Korganow, Thierry Martin and Pauline Soulas-Sprauel

      Article first published online: 29 OCT 2012 | DOI: 10.1002/emmm.201201595

      Thumbnail image of graphical abstract

      The authors identified a deficiency of Carabin expression in B cells as a novel gene expression abnormality in systemic lupus erythematosus and provide insight into its important function regulating autoimmunity.

    3. You have full text access to this OnlineOpen article
      Tumour inflammasome-derived IL-1β recruits neutrophils and improves local recurrence-free survival in EBV-induced nasopharyngeal carcinoma (pages 1276–1293)

      Lih-Chyang Chen, Li-Jie Wang, Nang-Ming Tsang, David M. Ojcius, Chia-Chun Chen, Chun-Nan OuYang, Chuen Hsueh, Ying Liang, Kai-Ping Chang, Chiu-Chin Chen and Yu-Sun Chang

      Article first published online: 15 OCT 2012 | DOI: 10.1002/emmm.201201569

      Thumbnail image of graphical abstract

      Inflammasomes detect infection and trigger inflammation. The authors find that in Epstein-Barr virusassociated nasopharyngeal carcinoma, inflammasomes recruit neutrophils, which produce IL-1beta and thereby inhibit tumor growth.

    4. You have full text access to this OnlineOpen article
      WLS inhibits melanoma cell proliferation through the β-catenin signalling pathway and induces spontaneous metastasis (pages 1294–1307)

      Pei-Tzu Yang, Jamie N. Anastas, Rachel A. Toroni, Michi M. Shinohara, Jamie M. Goodson, Anja K. Bosserhoff, Andy J. Chien and Randall T. Moon

      Article first published online: 6 NOV 2012 | DOI: 10.1002/emmm.201201486

      Thumbnail image of graphical abstract

      Even though WNT/ β-catenin signaling is downregulated, malignant melanomas express high levels of WNT ligands. Here, the authors show that reduced expression of the WNT secretory receptor WLS could be the cause of loss of WNT/β-catenin signaling.

    5. You have full text access to this OnlineOpen article
      MicroRNA-146a-mediated downregulation of IRAK1 protects mouse and human small intestine against ischemia/reperfusion injury (pages 1308–1319)

      Cécilia Chassin, Cordelia Hempel, Silvia Stockinger, Aline Dupont, Joachim F. Kübler, Jochen Wedemeyer, Alain Vandewalle and Mathias W. Hornef

      Article first published online: 9 NOV 2012 | DOI: 10.1002/emmm.201201298

      Thumbnail image of graphical abstract

      The authors identify Irak1 protein as a major regulator of Tlr-mediated innate immune responsiveness in intestinal epithelial cells and show that miR-146a controls innate immune hyperresponsiveness and prevents ischemia/reperfusion injury.

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