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EMBO Molecular Medicine

Cover image for Vol. 5 Issue 1

January 2013

Volume 5, Issue 1

  1. Masthead

    1. Top of page
    2. Masthead
    3. Perspective
    4. Closeup
    5. Report
    6. Research Articles
    7. Masthead
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      Masthead (pages i–ii)

      Version of Record online: 8 JAN 2013 | DOI: 10.1002/emmm.201390001

  2. Perspective

    1. Top of page
    2. Masthead
    3. Perspective
    4. Closeup
    5. Report
    6. Research Articles
    7. Masthead
    1. You have full text access to this OnlineOpen article
  3. Closeup

    1. Top of page
    2. Masthead
    3. Perspective
    4. Closeup
    5. Report
    6. Research Articles
    7. Masthead
    1. You have full text access to this OnlineOpen article
      The stem and roots of Wilms' tumours (pages 4–6)

      Peter Hohenstein

      Version of Record online: 13 DEC 2012 | DOI: 10.1002/emmm.201202173

    2. You have full text access to this OnlineOpen article
      The cancer stem cell model: B cell acute lymphoblastic leukaemia breaks the mould (pages 7–9)

      James Scott McClellan and Ravindra Majeti

      Version of Record online: 11 DEC 2012 | DOI: 10.1002/emmm.201202207

  4. Report

    1. Top of page
    2. Masthead
    3. Perspective
    4. Closeup
    5. Report
    6. Research Articles
    7. Masthead
    1. You have full text access to this OnlineOpen article
      Strategy for the creation of clinical grade hESC line banks that HLA-match a target population (pages 10–17)

      Laureen Jacquet, Emma Stephenson, Robert Collins, Heema Patel, Jane Trussler, Roaa Al-Bedaery, Pamela Renwick, Caroline Ogilvie, Robert Vaughan and Dusko Ilic

      Version of Record online: 19 NOV 2012 | DOI: 10.1002/emmm.201201973

      Thumbnail image of graphical abstract

      The authors developed a preselection method for the generation of HLA-matched hESC line banks and show that whole genome amplification of genomic DNA from a single blastomere is sufficient for rapid, reliable and accurate SNP typing.

  5. Research Articles

    1. Top of page
    2. Masthead
    3. Perspective
    4. Closeup
    5. Report
    6. Research Articles
    7. Masthead
    1. You have full text access to this OnlineOpen article
      The isolation and characterization of renal cancer initiating cells from human Wilms' tumour xenografts unveils new therapeutic targets (pages 18–37)

      Naomi Pode-Shakked, Rachel Shukrun, Michal Mark-Danieli, Peter Tsvetkov, Sarit Bahar, Sara Pri-Chen, Ronald S. Goldstein, Eithan Rom-Gross, Yoram Mor, Edward Fridman, Karen Meir, Amos Simon, Marcus Magister, Naftali Kaminski, Victor S. Goldmacher, Orit Harari-Steinberg and Benjamin Dekel

      Version of Record online: 13 DEC 2012 | DOI: 10.1002/emmm.201201516

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      Here, the authors report the isolation and characterisation of Wilms' tumour stem cells and show that targeting a cancer cell population enriched for cancer-initiating cell activity leads to tumour eradication in a mouse model.

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      Acute B lymphoblastic leukaemia-propagating cells are present at high frequency in diverse lymphoblast populations (pages 38–51)

      Klaus Rehe, Kerrie Wilson, Simon Bomken, Daniel Williamson, Julie Irving, Monique L. den Boer, Martin Stanulla, Martin Schrappe, Andrew G. Hall, Olaf Heidenreich and Josef Vormoor

      Version of Record online: 11 DEC 2012 | DOI: 10.1002/emmm.201201703

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      Leukemia propagating cells (LPCs) in B-ALL are frequent and phenotypically diverse and do not follow a hierarchically organized cancer stem cell model, clarifying a controversial area.

    3. You have full text access to this OnlineOpen article
      Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease (pages 52–63)

      Nambirajan Govindarajan, Pooja Rao, Susanne Burkhardt, Farahnaz Sananbenesi, Oliver M. Schlüter, Frank Bradke, Jianrong Lu and André Fischer

      Version of Record online: 26 NOV 2012 | DOI: 10.1002/emmm.201201923

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      The authors identified HDAC6 as a novel therapeutic target in Alzheimer's disease. Reducing HDAC6 protein levels in the brains of an AD mouse model improves memory and protects neurons against amyloid-β-induced impairment of mitochondrial trafficking.

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      Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival (pages 64–79)

      Jenny S. Henkel, David R. Beers, Shixiang Wen, Andreana L. Rivera, Karen M. Toennis, Joan E. Appel, Weihua Zhao, Dan H. Moore, Suzanne Z. Powell and Stanley H. Appel

      Version of Record online: 9 NOV 2012 | DOI: 10.1002/emmm.201201544

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      Amyotrophic lateral sclerosis is a heterogeneous disorder with differing sites of onset, rates of progression, length of disease, and pathological mechanisms. Here, the authors show that regulatory T cells influence progression in ALS patients.

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      Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy (pages 80–91)

      Eva Andres-Mateos, Heinrich Brinkmeier, Tyesha N. Burks, Rebeca Mejias, Daniel C. Files, Martin Steinberger, Arshia Soleimani, Ruth Marx, Jessica L. Simmers, Benjamin Lin, Erika Finanger Hedderick, Tom G. Marr, Brian M. Lin, Christophe Hourdé, Leslie A. Leinwand, Dietmar Kuhl, Michael Föller, Silke Vogelsang, Ivan Hernandez-Diaz, Dana K. Vaughan, Diego Alvarez de la Rosa, Florian Lang and Ronald D. Cohn

      Version of Record online: 19 NOV 2012 | DOI: 10.1002/emmm.201201443

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      Previous evidence suggests that Akt is the only determinant and regulator of cell survival in skeletal muscle. Here, the authors show that SGK1 is a novel and central factor mediating skeletal muscle preservation.

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      Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults (pages 92–104)

      Yisheng Yang, Benny Hung-Junn Chang and Lawrence Chan

      Version of Record online: 29 NOV 2012 | DOI: 10.1002/emmm.201201398

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      The authors show that administration or pharmacological induction of miR-146a represents a new strategy to control innate immune hyper-responsiveness and reduce tissue damage after transient hypoxia or ischemia/reperfusion.

    7. You have full text access to this OnlineOpen article
      Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis (pages 105–121)

      Sahar A. Saddoughi, Salih Gencer, Yuri K. Peterson, Katherine E. Ward, Archana Mukhopadhyay, Joshua Oaks, Jacek Bielawski, Zdzislaw M. Szulc, Raquela J. Thomas, Shanmugam P. Selvam, Can E. Senkal, Elizabeth Garrett-Mayer, Ryan M. De Palma, Dzmitry Fedarovich, Angen Liu, Amyn A. Habib, Robert V. Stahelin, Danilo Perrotti and Besim Ogretmen

      Version of Record online: 25 NOV 2012 | DOI: 10.1002/emmm.201201283

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      The authors show that targeting I2PP2A/SET by FTY720 suppresses lung tumour growth via PP2A-dependent RIPK1 activation leading to necroptosis.

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      Haematopoietic stem cell survival and transplantation efficacy is limited by the BH3-only proteins Bim and Bmf (pages 122–136)

      Verena Labi, Daniela Bertele, Claudia Woess, Denise Tischner, Florian J. Bock, Sven Schwemmers, Heike L. Pahl, Stephan Geley, Mirjam Kunze, Charlotte M. Niemeyer, Andreas Villunger and Miriam Erlacher

      Version of Record online: 24 NOV 2012 | DOI: 10.1002/emmm.201201235

      Thumbnail image of graphical abstract

      Many haematological diseases can only be cured by blood stem cell transplantation. The authors show that apoptosis inhibition at the level of Bcl-2 proteins leads to an extended life span of blood stem cells and facilitates engraftment in vivo.

    9. You have full text access to this OnlineOpen article
      The orphan receptor TR3 participates in angiotensin II-induced cardiac hypertrophy by controlling mTOR signalling (pages 137–148)

      Rong-Hao Wang, Jian-Ping He, Mao-Long Su, Jie Luo, Ming Xu, Xiao-Dan Du, Hang-Zi Chen, Wei-Jia Wang, Yuan Wang, Nan Zhang, Bi-Xing Zhao, Wen-Xiu Zhao, Zhong-Gui Shan, Jiahuai Han, Chawnshang Chang and Qiao Wu

      Version of Record online: 29 NOV 2012 | DOI: 10.1002/emmm.201201369

      Thumbnail image of graphical abstract

      Persistent cardiac hypertrophy ultimately leads to cardiovascular disease. Here, the authors show that the nuclear receptor TR3 participates in angiotensin-induced cardiac hypertrophy by controlling mTORC1 signaling.

    10. You have full text access to this OnlineOpen article
      Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence (pages 149–166)

      Yan Liu, Oriana E. Hawkins, Yingjun Su, Anna E. Vilgelm, Tammy Sobolik, Yee-Mon Thu, Sara Kantrow, Ryan C. Splittgerber, Sarah Short, Katayoun I. Amiri, Jeffery A. Ecsedy, Jeffery A. Sosman, Mark C. Kelley and Ann Richmond

      Version of Record online: 25 NOV 2012 | DOI: 10.1002/emmm.201201378

      Thumbnail image of graphical abstract

      The authors suggest that aurora kinase inhibitors may effectively slow tumour growth via senescence to provide effective therapy for certain melanoma patients.

  6. Masthead

    1. Top of page
    2. Masthead
    3. Perspective
    4. Closeup
    5. Report
    6. Research Articles
    7. Masthead
    1. You have full text access to this OnlineOpen article
      Masthead (pages i–ii)

      Version of Record online: 3 JAN 2013 | DOI: 10.1002/emmm.201390000

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