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EMBO Molecular Medicine

Cover image for Vol. 5 Issue 10

October 2013

Volume 5, Issue 10

Pages 1459–1635, i–ii

  1. Closeups

    1. Top of page
    2. Closeups
    3. Review
    4. Research Articles
    5. Corrigendum
    6. Masthead
    1. You have full text access to this OnlineOpen article
      Need glucose to sprout: local metabolic control of angiogenesis (pages 1459–1461)

      Anne Eichmann and Michael Simons

      Version of Record online: 27 AUG 2013 | DOI: 10.1002/emmm.201303174

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      Targeting protein–protein interactions to rescue Δf508-cftr: a novel corrector approach to treat cystic fibrosis (pages 1462–1464)

      Isabel Devesa, Gregorio Fernández-Ballester and Antonio Ferrer-Montiel

      Version of Record online: 27 AUG 2013 | DOI: 10.1002/emmm.201303301

  2. Review

    1. Top of page
    2. Closeups
    3. Review
    4. Research Articles
    5. Corrigendum
    6. Masthead
    1. You have full text access to this OnlineOpen article
      Antimicrobial peptides and gut microbiota in homeostasis and pathology (pages 1465–1483)

      Maureen J. Ostaff, Eduard Friedrich Stange and Jan Wehkamp

      Version of Record online: 23 AUG 2013 | DOI: 10.1002/emmm.201201773

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      This review discusses how a balanced hostmicrobe interaction is multifactorial and depends on antimicrobial peptides, gut microbiota, innate immunity and epithelial pathways. Dysregulation of this system results in several intestinal disorders.

  3. Research Articles

    1. Top of page
    2. Closeups
    3. Review
    4. Research Articles
    5. Corrigendum
    6. Masthead
    1. You have full text access to this OnlineOpen article
      Discovery of novel potent ΔF508-CFTR correctors that target the nucleotide binding domain (pages 1484–1501)

      Norbert Odolczyk, Janine Fritsch, Caroline Norez, Nathalie Servel, Melanie Faria da Cunha, Sara Bitam, Anna Kupniewska, Ludovic Wiszniewski, Julien Colas, Krzysztof Tarnowski, Danielle Tondelier, Ariel Roldan, Emilie L. Saussereau, Patricia Melin-Heschel, Grzegorz Wieczorek, Gergely L. Lukacs, Michal Dadlez, Grazyna Faure, Harald Herrmann, Mario Ollero, Frédéric Becq, Piotr Zielenkiewicz and Aleksander Edelman

      Version of Record online: 27 AUG 2013 | DOI: 10.1002/emmm.201302699

      Thumbnail image of graphical abstract

      A virtual screening strategy led to potent novel compounds (correctors), able to correct the function of mutant (ΔF508-CFTR) CFTR and based on their ability to inhibit interactions between mutant ΔF508-CFTR and keratin 8.

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      Triple negative breast cancer initiating cell subsets differ in functional and molecular characteristics and in γ-secretase inhibitor drug responses (pages 1502–1522)

      Diana J. Azzam, Dekuang Zhao, Jun Sun, Andy J. Minn, Prathibha Ranganathan, Katherine Drews-Elger, Xiaoqing Han, Manuel Picon-Ruiz, Candace A. Gilbert, Seth A. Wander, Anthony J. Capobianco, Dorraya El-Ashry and Joyce M. Slingerland

      Version of Record online: 27 AUG 2013 | DOI: 10.1002/emmm.201302558

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      Triple-negative breast cancer stem cells are shown to generate two different subsets. One with an activated Notch pathway and thus sensitive to gammasecretase inhibitors, the other resistant. This heterogeneity might ultimately limit efficacy of GSI.

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      The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation (pages 1523–1536)

      Rossella Lucá, Michele Averna, Francesca Zalfa, Manuela Vecchi, Fabrizio Bianchi, Giorgio La Fata, Franca Del Nonno, Roberta Nardacci, Marco Bianchi, Paolo Nuciforo, Sebastian Munck, Paola Parrella, Rute Moura, Emanuela Signori, Robert Alston, Anna Kuchnio, Maria Giulia Farace, Vito Michele Fazio, Mauro Piacentini, Bart De Strooper, Tilmann Achsel, Giovanni Neri, Patrick Neven, D. Gareth Evans, Peter Carmeliet, Massimiliano Mazzone and Claudia Bagni

      Version of Record online: 16 SEP 2013 | DOI: 10.1002/emmm.201302847

      Thumbnail image of graphical abstract

      The fragile X mental retardation protein (FMRP) is shown for the first time with a role in breast cancer progression. FMRP is further shown to drive EMT by binding to and regulating vimentin and E-cadherin suggesting a role in metastasis formation.

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      Synergistic combination of valproic acid and oncolytic parvovirus H-1PV as a potential therapy against cervical and pancreatic carcinomas (pages 1537–1555)

      Junwei Li, Serena Bonifati, Georgi Hristov, Tiina Marttila, Séverine Valmary-Degano, Sven Stanzel, Martina Schnölzer, Christiane Mougin, Marc Aprahamian, Svitlana P. Grekova, Zahari Raykov, Jean Rommelaere and Antonio Marchini

      Version of Record online: 17 SEP 2013 | DOI: 10.1002/emmm.201302796

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      Sub-lethal doses of the histone deacetylase inhibitor valproic acid synergistically enhance the oncolytic activity of H-1PV against a range of human cancer cell lines derived from patients with cervical and pancreatic carcinomas and in xenograft models.

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      Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease (pages 1556–1568)

      Orit Harari-Steinberg, Sally Metsuyanim, Dorit Omer, Yehudit Gnatek, Rotem Gershon, Sara Pri-Chen, Derya D. Ozdemir, Yaniv Lerenthal, Tzahi Noiman, Herzel Ben-Hur, Zvi Vaknin, David F. Schneider, Bruce J. Aronow, Ronald S. Goldstein, Peter Hohenstein and Benjamin Dekel

      Version of Record online: 2 SEP 2013 | DOI: 10.1002/emmm.201201584

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      This study reports the first isolation of a NCAM1+ population of nephron progenitor cells that can be propagated, form tubules and integrate into kidneys of a mouse model of renal disease, suggesting therapeutic avenues in regenerative medicine.

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      VBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects (pages 1569–1585)

      Christopher R. Heier, Jesse M. Damsker, Qing Yu, Blythe C. Dillingham, Tony Huynh, Jack H. Van der Meulen, Arpana Sali, Brittany K. Miller, Aditi Phadke, Luana Scheffer, James Quinn, Kathleen Tatem, Sarah Jordan, Sherry Dadgar, Olga C. Rodriguez, Chris Albanese, Michael Calhoun, Heather Gordish-Dressman, Jyoti K. Jaiswal, Edward M. Connor, John M. McCall, Eric P. Hoffman, Erica K. M. Reeves and Kanneboyina Nagaraju

      Version of Record online: 9 SEP 2013 | DOI: 10.1002/emmm.201302621

      Thumbnail image of graphical abstract

      Through studying the molecular mechanisms of glucocorticoids in Duchenne Muscular Dystrophy, the authors developed VBP15 as a novel oral drug with great therapeutic potentials in mdx mice.VBP15 acts like steroids, yet lacks their side effects.

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      Pathological impact of SMN2 mis-splicing in adult SMA mice (pages 1586–1601)

      Kentaro Sahashi, Karen K. Y. Ling, Yimin Hua, John Erby Wilkinson, Tomoki Nomakuchi, Frank Rigo, Gene Hung, David Xu, Ya-Ping Jiang, Richard Z. Lin, Chien-Ping Ko, C. Frank Bennett and Adrian R. Krainer

      Version of Record online: 9 SEP 2013 | DOI: 10.1002/emmm.201302567

      Thumbnail image of graphical abstract

      An SMA mouse model mice mimicking adult-onset SMA was generated, witha characteristic late-onset motor phenotype. This study also suggests that high SMN levels are not required in adults, and that there is a broad therapeutic time window for treatment of adult-onset SMA.

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      MicroRNA-146b promotes adipogenesis by suppressing the SIRT1-FOXO1 cascade (pages 1602–1612)

      Jiyun Ahn, Hyunjung Lee, Chang Hwa Jung, Tae Il Jeon and Tae Youl Ha

      Version of Record online: 6 SEP 2013 | DOI: 10.1002/emmm.201302647

      Thumbnail image of graphical abstract

      miR-146b is found here to regulate adipogenesis by targeting SIRT1 and increasing acetylated FOXO1. Inhibiting miR-146b reduced body weight and fat mass in obese mice. This novel data indicate miR-146b as a potential new target against obesity.

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      Alteration of the microRNA network during the progression of Alzheimer's disease (pages 1613–1634)

      Pierre Lau, Koen Bossers, Rekin's Janky, Evgenia Salta, Carlo Sala Frigerio, Shahar Barbash, Roy Rothman, Annerieke S. R. Sierksma, Amantha Thathiah, David Greenberg, Aikaterini S. Papadopoulou, Tilmann Achsel, Torik Ayoubi, Hermona Soreq, Joost Verhaagen, Dick F. Swaab, Stein Aerts and Bart De Strooper

      Version of Record online: 9 SEP 2013 | DOI: 10.1002/emmm.201201974

      Thumbnail image of graphical abstract

      Little is known about the global transcription of microRNAs in Alzheimer's disease (AD). Here, while a few deregulated microRNAs are observed in localized brain areas of AD patients, miR-132-3p downregulation correlates with disease progression.

  4. Corrigendum

    1. Top of page
    2. Closeups
    3. Review
    4. Research Articles
    5. Corrigendum
    6. Masthead
    1. You have full text access to this OnlineOpen article
      Corrigendum (page 1635)

      Version of Record online: 2 OCT 2013 | DOI: 10.1002/emmm.201370102

      This article corrects:

      Initial HIV mucosal infection and dendritic cells

      Vol. 5, Issue 5, 658–660, Version of Record online: 7 MAY 2013

  5. Masthead

    1. Top of page
    2. Closeups
    3. Review
    4. Research Articles
    5. Corrigendum
    6. Masthead
    1. You have full text access to this OnlineOpen article

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