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EMBO Molecular Medicine

Cover image for Vol. 5 Issue 3

March 2013

Volume 5, Issue 3

Pages 327–482, i–ii

  1. Perspective

    1. Top of page
    2. Perspective
    3. Reviews
    4. Research Articles
    5. Corrigendum
    6. Masthead
    1. You have full text access to this OnlineOpen article
      Autophagic control of cell ‘stemness’ (pages 327–331)

      Huize Pan, Ning Cai, Mo Li, Guang-Hui Liu and Juan Carlos Izpisua Belmonte

      Article first published online: 5 MAR 2013 | DOI: 10.1002/emmm.201201999

  2. Reviews

    1. Top of page
    2. Perspective
    3. Reviews
    4. Research Articles
    5. Corrigendum
    6. Masthead
    1. You have full text access to this OnlineOpen article
      Aminoacyl-tRNA synthetases in medicine and disease (pages 332–343)

      Peng Yao and Paul L. Fox

      Article first published online: 21 FEB 2013 | DOI: 10.1002/emmm.201100626

      Thumbnail image of graphical abstract

      Aminoacyl-tRNA synthetases have been implicated in multiple pathologies and have potential as pharmacological targets and therapeutic reagents. This review discusses recent findings on the roles of ARSs in human disease and therapeutic approaches.

    2. You have full text access to this OnlineOpen article
      SIRT1 and SIRT2: emerging targets in neurodegeneration (pages 344–352)

      Gizem Donmez and Tiago F. Outeiro

      Article first published online: 18 FEB 2013 | DOI: 10.1002/emmm.201302451

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      Sirtuins (SIRTs) are NAD-dependent protein deacetylases, which have been implicated in age-related diseases. This review discusses recent findings on the roles of SIRT1 and SIRT2 in neurodegenerative diseases and in potential therapeutic approaches.

  3. Research Articles

    1. Top of page
    2. Perspective
    3. Reviews
    4. Research Articles
    5. Corrigendum
    6. Masthead
    1. You have full text access to this OnlineOpen article
      A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia (pages 353–365)

      Jiewen Zhu, Longen Zhou, Guikai Wu, Heiko Konig, Xiaoqin Lin, Guideng Li, Xiao-Long Qiu, Chi-Fen Chen, Chun-Mei Hu, Erin Goldblatt, Ravi Bhatia, A. Richard Chamberlin, Phang-Lang Chen and Wen-Hwa Lee

      Article first published online: 22 JAN 2013 | DOI: 10.1002/emmm.201201760

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      A newly identified RAD51 inhibitor leading to degradation of RAD51 via the proteasome pathway inhibits cancer cell survival and greatly increases life spans in a mouse chronic myeloid leukaemia model.

    2. You have full text access to this OnlineOpen article
      A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α (pages 366–383)

      Ulrike Begley, Maria Soledad Sosa, Alvaro Avivar-Valderas, Ashish Patil, Lauren Endres, Yeriel Estrada, Clement T.Y. Chan, Dan Su, Peter C. Dedon, Julio A. Aguirre-Ghiso and Thomas Begley

      Article first published online: 4 FEB 2013 | DOI: 10.1002/emmm.201201161

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      The human tRNA methyltransferase 9-like (hTRM9L) gene is turned off in many cancers and hTRM9- deficient cells are susceptible to killing by aminoglycoside antibiotics, suggesting that these drugs could be re-purposed to treat late stage cancers.

    3. You have full text access to this OnlineOpen article
      Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain (pages 384–396)

      Fei Xing, Aya Kobayashi, Hiroshi Okuda, Misako Watabe, Sudha K. Pai, Puspa R. Pandey, Shigeru Hirota, Andrew Wilber, Yin-Yuan Mo, Brian E. Moore, Wen Liu, Koji Fukuda, Megumi Iiizumi, Sambad Sharma, Yin Liu, Kerui Wu, Elizabeth Peralta and Kounosuke Watabe

      Article first published online: 5 MAR 2013 | DOI: 10.1002/emmm.201201623

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      In the mouse brain, metastatic breast cancer cells secrete IL-1beta, which induces the Notch pathway promoting breast cancer cell stemness and thereby leading to metastasis. The Notch inhibitor Compound E is shown to suppress brain metastasis growth.

    4. You have full text access to this OnlineOpen article
      Gene transfer of master autophagy regulator TFEB results in clearance of toxic protein and correction of hepatic disease in alpha-1-anti-trypsin deficiency (pages 397–412)

      Nunzia Pastore, Keith Blomenkamp, Fabio Annunziata, Pasquale Piccolo, Pratibha Mithbaokar, Rosa Maria Sepe, Francesco Vetrini, Donna Palmer, Philip Ng, Elena Polishchuk, Simona Iacobacci, Roman Polishchuk, Jeffrey Teckman, Andrea Ballabio and Nicola Brunetti-Pierri

      Article first published online: 4 FEB 2013 | DOI: 10.1002/emmm.201202046

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      The authors show that transcription factor EB (TFEB) gene transfer corrects liver disease in alpha-1-antitrypsin deficiency, underlying the potential to extend this novel strategy to other human disorders.

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      Alterations in cardiac DNA methylation in human dilated cardiomyopathy (pages 413–429)

      Jan Haas, Karen S. Frese, Yoon Jung Park, Andreas Keller, Britta Vogel, Anders M. Lindroth, Dieter Weichenhan, Jennifer Franke, Simon Fischer, Andrea Bauer, Sabine Marquart, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Doreen Köhler, Nadine M. Wolf, Sarah Hassel, Rouven Nietsch, Thomas Wieland, Philipp Ehlermann, Jobst-Hendrik Schultz, Andreas Dösch, Derliz Mereles, Stefan Hardt, Johannes Backs, Jörg D. Hoheisel, Christoph Plass, Hugo A. Katus and Benjamin Meder

      Article first published online: 22 JAN 2013 | DOI: 10.1002/emmm.201201553

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      Dilated cardiomyopathy is one the most frequent heart muscle diseases, which is responsible for one third of all heart failure cases. Here, the authors show widespread changes in DNA methylation patterns responsible for the disease.

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      SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin (pages 430–440)

      Petra Simic, Kayvan Zainabadi, Eric Bell, David B. Sykes, Borja Saez, Sutada Lotinun, Roland Baron, David Scadden, Ernestina Schipani and Leonard Guarente

      Article first published online: 30 JAN 2013 | DOI: 10.1002/emmm.201201606

      Thumbnail image of graphical abstract

      The authors show that in mesenchymal stem cells, SIRT1 deacetylates β-catenin to trigger its nuclear translocation and activation of genes for differentiation.

      Corrected by:

      Corrigendum: SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin

      Vol. 5, Issue 3, 482, Article first published online: 5 MAR 2013

    7. You have full text access to this OnlineOpen article
      Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay (pages 441–455)

      Loredana Fiorentino, Michele Cavalera, Stefano Menini, Valentina Marchetti, Maria Mavilio, Marta Fabrizi, Francesca Conserva, Viviana Casagrande, Rossella Menghini, Paola Pontrelli, Ivan Arisi, Mara D'Onofrio, Davide Lauro, Rama Khokha, Domenico Accili, Giuseppe Pugliese, Loreto Gesualdo, Renato Lauro and Massimo Federici

      Article first published online: 12 FEB 2013 | DOI: 10.1002/emmm.201201475

      Thumbnail image of graphical abstract

      Loss of TIMP3 is a hallmark of diabetic kidney disease in human and mouse models. Concomitant STAT1-dependent loss of FoxO1 activity modulates expression of oxidative and protective autophagy genes and results in glomeruli damage.

    8. You have full text access to this OnlineOpen article
      LPS resistance of SPRET/Ei mice is mediated by Gilz, encoded by the Tsc22d3 gene on the X chromosome (pages 456–470)

      Iris Pinheiro, Lien Dejager, Ioanna Petta, Sofie Vandevyver, Leen Puimège, Tina Mahieu, Marlies Ballegeer, Filip Van Hauwermeiren, Carlo Riccardi, Marnik Vuylsteke and Claude Libert

      Article first published online: 5 MAR 2013 | DOI: 10.1002/emmm.201201683

      Thumbnail image of graphical abstract

      Gilz is shown to have a strong anti-inflammatory role in acute inflammation like sepsis: Increased levels of Gilz enhance the protection against the harmful effects of LPS.

    9. You have full text access to this OnlineOpen article
      Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes (pages 471–481)

      Oliver Soehnlein, Maik Drechsler, Yvonne Döring, Dirk Lievens, Helene Hartwig, Klaus Kemmerich, Almudena Ortega-Gómez, Manuela Mandl, Santosh Vijayan, Delia Projahn, Christoph D. Garlichs, Rory R. Koenen, Mihail Hristov, Esther Lutgens, Alma Zernecke and Christian Weber

      Article first published online: 18 FEB 2013 | DOI: 10.1002/emmm.201201717

      Thumbnail image of graphical abstract

      The Authors establish the impact of classical monocytes on progression of atherosclerotic disease and identify a sequential role of the chemokine CXCL1 and the chemokine receptors CCR1/CCR5 in their mobilisation and recruitment.

  4. Corrigendum

    1. Top of page
    2. Perspective
    3. Reviews
    4. Research Articles
    5. Corrigendum
    6. Masthead
    1. You have open access to this content
      SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin (page 482)

      Petra Simic, Kayvan Zainabadi, Eric Bell, David B. Sykes, Borja Saez, Sutada Lotinun, Roland Baron, David Scadden, Ernestina Schipani and Leonard Guarente

      Article first published online: 5 MAR 2013 | DOI: 10.1002/emmm.201390004

      This article corrects:

      SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin

      Vol. 5, Issue 3, 430–440, Article first published online: 30 JAN 2013

  5. Masthead

    1. Top of page
    2. Perspective
    3. Reviews
    4. Research Articles
    5. Corrigendum
    6. Masthead
    1. You have open access to this content
      Masthead (pages i–ii)

      Article first published online: 5 MAR 2013 | DOI: 10.1002/emmm.201390005

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