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EMBO Molecular Medicine

Cover image for Vol. 5 Issue 7

July 2013

Volume 5, Issue 7

Pages i–ii

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Closeups
    4. Review
    5. Research Articles
    6. Masthead
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      Cover (EMBO Mol. Med. 7/2013) (page NP)

      Version of Record online: 3 JUL 2013 | DOI: 10.1002/emmm.201370071

  2. Closeups

    1. Top of page
    2. Cover Picture
    3. Closeups
    4. Review
    5. Research Articles
    6. Masthead
    1. You have full text access to this OnlineOpen article
    2. You have full text access to this OnlineOpen article
  3. Review

    1. Top of page
    2. Cover Picture
    3. Closeups
    4. Review
    5. Research Articles
    6. Masthead
    1. You have full text access to this OnlineOpen article
      Balancing the fat: lipid droplets and human disease (pages 973–983)

      Natalie Krahmer, Robert V. Farese Jr and Tobias C. Walther

      Version of Record online: 6 JUN 2013 | DOI: 10.1002/emmm.201100671

      Thumbnail image of graphical abstract

      Too many or too few lipid droplets during excess or deficient fat storage lead to many different human diseases. Recent insights into lipid droplet biology and functions shed new light on mechanisms underlying those metabolic pathologies.

  4. Research Articles

    1. Top of page
    2. Cover Picture
    3. Closeups
    4. Review
    5. Research Articles
    6. Masthead
    1. You have full text access to this OnlineOpen article
      Brain microvessel cross-presentation is a hallmark of experimental cerebral malaria (pages 984–999)

      Shanshan W. Howland, Chek Meng Poh, Sin Yee Gun, Carla Claser, Benoit Malleret, Nilabh Shastri, Florent Ginhoux, Gijsbert M. Grotenbreg and Laurent Rénia

      Version of Record online: 16 MAY 2013 | DOI: 10.1002/emmm.201202273

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      Cerebral malaria (CM) remains a deadly yet poorly understood complication of Plasmodium falciparum infection. Here, brain microvessels cross-present P. berghei epitopes that elicit a strong CD8-response resulting in experimental CM pathogenesis.

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      Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF (pages 1000–1016)

      Roosmarijn E. Vandenbroucke, Eline Dejonckheere, Filip Van Hauwermeiren, Sofie Lodens, Riet De Rycke, Elien Van Wonterghem, An Staes, Kris Gevaert, Carlos López-Otin and Claude Libert

      Version of Record online: 30 MAY 2013 | DOI: 10.1002/emmm.201202100

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      MMP13 is shown here for the 1st time to convert TNFα leading to intestinal inflammation, ER stress and altered epithelial barrier in an endotoxemia mouse model. These data suggest MMP13 as a novel drug target for the treatment of sepsis and IBD.

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      MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways (pages 1017–1034)

      Henry S. Cheng, Nirojini Sivachandran, Andrew Lau, Emilie Boudreau, Jimmy L. Zhao, David Baltimore, Paul Delgado-Olguin, Myron I. Cybulsky and Jason E. Fish

      Version of Record online: 3 JUN 2013 | DOI: 10.1002/emmm.201202318

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      miR-146 microRNA is induced by proinflammatory cytokines and acts to inhibit vascular inflammation by repressing endothelial activation through the inhibition of both transcriptional and posttranscriptional endothelial proinflammatory pathways.

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      Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN-λ and elevated secretion of Cxcl10 (pages 1035–1050)

      Christoph Burkart, Kei-ichiro Arimoto, Tingdong Tang, Xiuli Cong, Nengming Xiao, Yun-Cai Liu, Sergei V. Kotenko, Lesley G. Ellies and Dong-Er Zhang

      Version of Record online: 16 MAY 2013 | DOI: 10.1002/emmm.201201864

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      Usp18 regulates the mammary tumor microenvironment via IFN-λ signalling in epithelial cells: secreted Cxcl10 attract Th1 cells that will block tumor growth. These findings provide new candidates for epithelial breast cancer immunotherapy.

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      Functional genomics identifies five distinct molecular subtypes with clinical relevance and pathways for growth control in epithelial ovarian cancer (pages 1051–1066)

      Tuan Zea Tan, Qing Hao Miow, Ruby Yun-Ju Huang, Meng Kang Wong, Jieru Ye, Jieying Amelia Lau, Meng Chu Wu, Luqman Hakim Bin Abdul Hadi, Richie Soong, Mahesh Choolani, Ben Davidson, Jahn M. Nesland, Ling-Zhi Wang, Noriomi Matsumura, Masaki Mandai, Ikuo Konishi, Boon-Cher Goh, Jeffrey T. Chang, Jean Paul Thiery and Seiichi Mori

      Version of Record online: 13 MAY 2013 | DOI: 10.1002/emmm.201201823

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      Ovarian carcinomas remain a leading cause of cancer death among woman worldwide. Here, a novel rational patient stratification is proposed to unravel the heterogeneity of these cancers and provide means to guide novel intervention strategies.

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      CDK-mediated activation of the SCFFBXO28 ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer (pages 1067–1086)

      Diana Cepeda, Hwee-Fang Ng, Hamid Reza Sharifi, Salah Mahmoudi, Vanessa Soto Cerrato, Erik Fredlund, Kristina Magnusson, Helén Nilsson, Alena Malyukova, Juha Rantala, Daniel Klevebring, Francesc Viñals, Nimesh Bhaskaran, Siti Mariam Zakaria, Aldwin Suryo Rahmanto, Stefan Grotegut, Michael Lund Nielsen, Cristina Al-Khalili Szigyarto, Dahui Sun, Mikael Lerner, Sanjay Navani, Martin Widschwendter, Mathias Uhlén, Karin Jirström, Fredrik Pontén, James Wohlschlegel, Dan Grandér, Charles Spruck, Lars-Gunnar Larsson and Olle Sangfelt

      Version of Record online: 14 JUN 2013 | DOI: 10.1002/emmm.201202341

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      FBXO28 is identified as part of a SCF complex acting as a regulator of tumor cell proliferation and an important modifier of MYC function. FBXO28 may be a new prognostic factor in breast cancer and a new potential drug target in MYC- driven tumors.

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      ERBB4 confers metastatic capacity in Ewing sarcoma (pages 1087–1102)

      Ariadna Mendoza-Naranjo, Amal El-Naggar, Daniel H. Wai, Priti Mistry, Nikola Lazic, Fernanda Rocha Rojas Ayala, Isabela Werneck da Cunha, Pablo Rodriguez-Viciana, Hongwei Cheng, Jose H. Tavares Guerreiro Fregnani, Patrick Reynolds, Robert J. Arceci, Andrew Nicholson, Timothy J. Triche, Fernando A. Soares, Adrienne M. Flanagan, Yuzhuo Z. Wang, Sandra J. Strauss and Poul H. Sorensen

      Version of Record online: 16 MAY 2013 | DOI: 10.1002/emmm.201202343

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      The Authors show that ERBB4 is a biological driver of metastasis in the pediatric bone tumour Ewing sarcoma and identify a novel ERBB4-PI3K-Akt-FAK-Rac1 pathway associated with aggressive disease.

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      Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds (pages 1103–1118)

      Jonathan J. Cherry, Erkan Y. Osman, Matthew C. Evans, Sungwoon Choi, Xuechao Xing, Gregory D. Cuny, Marcie A. Glicksman, Christian L. Lorson and Elliot J. Androphy

      Version of Record online: 5 JUN 2013 | DOI: 10.1002/emmm.201202305

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      Spinal muscular atrophy (SMA) is caused by loss of SMN and is one of the leading heritable causes of infant death. The Authors describe new small molecules that increase SMN levels leading to improved lifespan and motor function in a SMA mouse model.

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      Caudo-rostral brain spreading of α-synuclein through vagal connections (pages 1119–1127)

      Ayse Ulusoy, Raffaella Rusconi, Blanca I. Pérez-Revuelta, Ruth E. Musgrove, Michael Helwig, Bettina Winzen-Reichert and Donato A. Di Monte

      Version of Record online: 23 MAY 2013 | DOI: 10.1002/emmm.201302475

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      α-synuclein lesions spreading in the brain is characteristic of Parkinson's disease and used to stage the disease severity. Here, a new rat model can explain the caudo-rostral pattern of disease progression providing insights into PD pathogenesis.

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      Rescue of cardiomyopathy through U7snRNA-mediated exon skipping in Mybpc3-targeted knock-in mice (pages 1128–1145)

      Christina Gedicke-Hornung, Verena Behrens-Gawlik, Silke Reischmann, Birgit Geertz, Doreen Stimpel, Florian Weinberger, Saskia Schlossarek, Guillaume Précigout, Ingke Braren, Thomas Eschenhagen, Giulia Mearini, Stéphanie Lorain, Thomas Voit, Patrick A. Dreyfus, Luis Garcia and Lucie Carrier

      Version of Record online: 29 MAY 2013 | DOI: 10.1002/emmm.201202168

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      Exon skipping is a promising therapy for selected genetic diseases. Here, the authors show as a proof-of-principle that MYBPC3 mutation-induced cardiomyopathy can be rescued by AAV-U7-antisense oligoribonucleotides in the heart of neonatal mice.

  5. Masthead

    1. Top of page
    2. Cover Picture
    3. Closeups
    4. Review
    5. Research Articles
    6. Masthead
    1. You have full text access to this Open Access content
      Masthead (EMBO Mol. Med. 7/2013) (pages i–ii)

      Version of Record online: 3 JUL 2013 | DOI: 10.1002/emmm.201370072

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